Follicular 17β-estradiol and progesterone concentrations and degree of cumulus cell expansion as predictors of in vivo-matured oocyte developmental competence in superstimulated heifers

Aardema, Hilde; Tol, Helena T A van; Oei, Christine; Gadella, Bart M.; Vos, P.L.A.M.

doi:10.1016/j.theriogenology.2013.05.025

Cited by 29 publications

(19 citation statements)

References 45 publications

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“…Previous studies have shown that the quantitative analysis of gene expression is a reliable parameter that might predict oocyte competence and embryo development in several species (Aardema et al, ; Bunel et al, ; Feuerstein et al, ; Huang & Wells, ; Landry et al, ). Considering our results and the global transcriptome analysis performed by Bunel et al (), we selected eight genes related to oocyte competence.…”

Section: Discussionmentioning

confidence: 99%

Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows

Velásquez

Mellisho

Castro

et al. 2018

Molecular Reproduction Devel

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The high metabolic activity to which the dairy cattle are exposed to maintain milk production altered steroid metabolism that affects reproductive physiology and reduce oocyte competence. Our aims were (a) to characterize the competence of immature oocytes collected from dairy cattle based on the expression of genes in cumulus cells (CCs) and (b) to improve oocyte competence to support preimplantation embryo development by the supplementation of maturation medium with bone morphogenetic protein 15 (BMP15) and/or anti‐mullerian hormone (AMH). Oocyte donors were identified at the moment of ovary collection and grouped by involuntarily culled dairy cows (Holstein breed) or beef cattle. The embryo development speed to blastocyst of the cull dairy cattle versus beef cattle (control group) was lower. Besides, <10% of oocytes (with CC biopsies) derived from dairy cattle were able to develop to the blastocyst stage. In addition, a higher level of expression and a positive correlation were observed in the expression of most of the genes evaluated (LUM, KRT18, KRT8, CLIC3, BMPR1B, and SLC38A3) in the cumulus–oocyte complexes that produced blastocysts versus those which did not develop correctly (arrested development). Further, use of BMP15 in the maturation of oocytes from dairy cattle seems to increase competence, modulating the expression of OCT4, SOX2, CDX2, GATA6, and TP1 in resulting blastocysts.

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Section: Discussionmentioning

confidence: 99%

Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows

Velásquez

Mellisho

Castro

et al. 2018

Molecular Reproduction Devel

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“…Upon LH activation, the level of P 4 in the periovulatory follicle increases at the expense of E 2 , resulting in a low E 2 :P 4 ratio (Dieleman et al, 1983). Competent oocytes, which are able to develop into blastocysts after fertilization, originate from periovulatory follicles with levels of E 2 ≤0.25 μM and P 4 ≥0.26 μM (Aardema et al, 2013b). In the non-periovulatory stage, a low E 2 :P 4 ratio indicates an aberrant inactive dominant follicle (Ireland and Roche, 1982).…”

Section: Discussionmentioning

confidence: 99%

Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress

Aardema

Gadella

Lest

et al. 2015

Journal of Dairy Science

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The fertility of high-yielding dairy cows has declined during the last 3 decades, in association with a more profound negative energy balance (NEB) during the early weeks postpartum. One feature of this NEB is a marked elevation in circulating free fatty acid (FFA) concentrations. During the early postpartum period (≤ d 42), circulatory FFA levels were measured weekly, and progesterone concentrations and the diameter of the dominant follicles were determined thrice weekly. Retrospectively, cows that ovulated within 35 d postpartum were grouped as "normal ovulating" cows (n = 5), and the others were grouped as "delayed ovulating" cows (n = 5). In both groups, high total FFA levels (>500 µM) were evident immediately postpartum. Interestingly, cows with delayed ovulation had higher plasma FFA concentrations in the first weeks postpartum compared with normal ovulating cows. In both cow groups, FFA decreased to control levels of non-NEB cows within 3 wk postpartum. The FFA compositions and concentrations in fluids from the dominant follicles of postpartum cows were not different between the normal and delayed ovulating cows when measured at potential insemination points: d 55, 80, and 105 postpartum. Interestingly, the concentration of monounsaturated oleic acid was higher and that of saturated stearic acid lower in follicular fluids of both groups compared with that in blood. The level of FFA in follicular fluid was correlated with the ratio of 17β-estradiol (E2) to progesterone (P4) in follicular fluid, with a relatively high level of unsaturated FFA in follicles with a low E2:P4 ratio. Taken together, these results indicate that a more severe NEB early postpartum is related to a delay in the first postpartum ovulation and does not affect FFA composition in follicular fluid at the preferred insemination time. The high FFA level in dominant follicles with a low E2:P4 ratio may be due to a different FFA metabolism in these follicles. The diagnostic value of this observation for selective screening of dominant follicles needs further investigation.

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“…Previous studies found a strong correlation between the diameter of the dominant follicle and the intrafollicular concentration of E 2 during the pre-ovulatory period (Ireland and Roche, 1982;Kruip and Dieleman 1985). Aardema et al (2013) did not find follicular diameter to be a good predictor of oocyte quality. Luteinizing hormone acts on granulosa cells to aromatize androgens to E 2 in follicles selected for further development.…”

Section: Preovulatory Follicle Characteristicsmentioning

confidence: 70%

“…Composition of the FF, especially the steroids, can influence follicle health and oocyte quality (Wehrman et al, 1993;Revelli et al, 2009). Aardema et al (2013) examined the association, in superstimulated healthy heifers, between steroid concentrations in preovulatory follicles and oocyte developmental competence: they found differences in the criteria for selection of cumulus-oocyte complexes between superstimulated heifers and nonstimulated cows, and this finding highlights the need to examine the RB phenomenon in nonstimulated cows. Zachut et al (2010) investigated the FF steroidal environment and oocyte competence in cows subjected to dietary changes, and Roth et al (2008) did so for those in various stages of lactation, but neither group addressed RB cows.…”

Section: Introductionmentioning

confidence: 99%

Preovulatory follicle characteristics and oocyte competence in repeat breeder dairy cows

Sood

Zachut

Dekel

et al. 2017

Journal of Dairy Science

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The varied and elusive etiology of repeat breeding (RB) in dairy cows necessitates evaluation of oocytes and follicles, which have not previously been assessed together. Accordingly, we evaluated characteristics of preovulatory follicles and the competence of oocytes in control (CTL) and RB cows. The estrous cycles of 35 cows (18 CTL and 17 RB) were synchronized using PGF and estrus detection. Cows with a corpus luteum were treated with PGF and, 14 to 15 d after a visible behavioral estrus, they were administered a second PGF, followed 48 h later by follicular fluid (FF) aspiration of the preovulatory follicles. Estradiol (E)-active preovulatory follicles did not differ in diameter between the 2 groups of cows. However, FF of RB cows had higher E concentrations than that of CTL cows: 1,854.9 and 1,073.6 ng/mL, respectively, but similar androstenedione and progesterone concentrations. In the second part of the study, 14 consecutive ovum pick-ups (OPU) were performed in 5 CTL and 5 RB cows, at 3- to 4-d intervals. The RB and CTL cows did not differ in average numbers of follicles available per cow per session (7.1 and 7.3, respectively), oocyte recovery rates (42.2 and 44.1%, respectively), or cleavage rates (57.6 and 63.4%, respectively), but blastocyst production was markedly less in RB than in CTL cows (12.5 and 29.2%, respectively). We conclude that part of the RB cows' etiology occurs at an earlier phase of folliculogenesis, thereby impairing oocyte competence, and subsequently reducing the probability of normal fertilization, which diminish embryo vitality and development.

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Follicular 17β-estradiol and progesterone concentrations and degree of cumulus cell expansion as predictors of in vivo-matured oocyte developmental competence in superstimulated heifers

Cited by 29 publications

References 45 publications

Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows

Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows

Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress

Preovulatory follicle characteristics and oocyte competence in repeat breeder dairy cows

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