Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia: a systematic review and meta-analysis

Yang, Qi; Huang, Yanping; Wang, Hongxiang; Hu, Kai; Wang, Yixin; Huang, Yiran; Chen, Bin

doi:10.4103/1008-682x.139259

Cited by 42 publications

(21 citation statements)

References 27 publications

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“…First, semen analysis was not performed because of the difficulty in obtaining semen samples form asymptomatic patients. Although previous studies demonstrated that FSH level in adults seems to be correlated with spermatogenetic activity and to be a predictive marker for the sperm retrieval rate in adults with non-obstructive azoospermia, FSH alone was reported to be insufficient for prediction [17]. In addition, median age of patients included in the current study was 17.5, slightly younger to discuss the relation between serum FSH and semen quality based on previous reports.…”

Section: Discussionmentioning

confidence: 85%

“…In the present study, we investigated the risk factors affecting reproductive function in patients with HS. Given the difficulty in obtaining semen samples from asymptomatic patients, serum follicle-stimulating hormone (FSH) was used as a surrogate marker of spermatogenic function because previous studies demonstrated that FSH level in adults seems to be correlated with spermatogenetic activity [14, 15] and to be a predictive marker for the sperm retrieval rate in patients with non-obstructive azoospermia [16, 17], although exact role of FSH remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias

et al. 2019

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Purpose The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS.Materials and methodsAmong those with a history of HS surgery, patients in whom endocrinological evaluation regarding pituitary–gonadal axis was performed at 15 years of age or older between March 2004 and April 2018 were enrolled in the present study. High serum FSH was defined as greater than 10 mIU/ml. The severity of HS was divided into mild and severe. Factors affecting the post-pubertal high serum FSH were estimated.ResultsSeventy-nine patients were included in the present study. The severity of HS was mild in 35 and severe in 44. History of undescended testis (UDT) was confirmed in 12. High serum FSH was detected in nine. On logistic regression model analysis, a history of UDT was the only significant factor for high serum FSH. The incidence of high serum FSH in patients with UDT was significantly higher than that in those without UDT (58.3% vs 7.5%, p < 0.01). When stratified by severity of HS and the presence of UDT, high serum FSH was detected in 70% in patients with severe HS and UDT, whereas less than 10% in other groups.ConclusionsA history of UDT was a significant factor for post-pubertal high serum FSH in patients with HS. Accordingly, the presence of UDT may be a marker for impaired spermatogenesis in patients with HS, especially in severe cases.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias

et al. 2019

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“…Testicular volume, serum follicle-stimulating hormone (FSH) value, serum inhibin B value, and testis histopathology are the factors most focused on. [8] Predictive models were developed to evaluate all these factors and determine successful sperm retrieval with TESE. [9] However, the predictive ability of all these models is limited.…”

Section: Introductionmentioning

confidence: 99%

Analysis of factors affecting repeat microdissection testicular sperm extraction outcomes in infertile men

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Şimşir

et al. 2019

Turkish Journal of Urology

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Objective: There is no clear consensus on which patients and how many of microscopic testicular sperm extraction (mTESE) procedures will be successful. In this study, we aimed to evaluate the sperm retrieval rates and factors affecting these rates in men who underwent repeat mTESEs. Material and methods: A total of 346 patients who underwent mTESE for sperm retrieval were included in the study. Patients were divided into groups according to the number of mTESE operations. Patients' karyotype, follicle-stimulating hormone (FSH) and testosterone levels, varicocele presence, and testis volumes were recorded from patient files. The sperm retrieval rates were compared between groups, and predicting factors for successful sperm retrieval were evaluated. Results: Microscopic TESE was applied for the first time in 244 patients, 1-2 times in 73 patients, and 3-4 times in 29 patients. There was a significant difference between groups in preoperative FSH values and postoperative testicular histopathology (p= 0.004 and p<0.001). The sperm retrieval rate in the group of patients who had not undergone previous TESE was higher than the group of patients that had undergone TESE for 1-2 times and 3-4 times (p= 0.028). In addition, testicular volume, histology, karyotype, and Y-chromosome microdeletion were predicting factors for successful sperm retrieval (p= 0.011, p= 0.039, p= 0.002, and p<0.001, respectively). Conclusion: Our results confirm the necessity for repeat mTESE operations to be performed by experienced surgeons in reference centers to optimize the chance of reduced sperm retrieval rates with recurrent biopsies.

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“…Finding such an indicator is particularly important, which to some extent can reduce the risk of testicular dysfunction after testicular surgery. In the current clinical practice, serum follicle-stimulating hormone (FSH), testosterone (T), and testicular volume have been commonly used as indicators of sperm retrieval rate in preoperative evaluation, but the clinical value of these parameters is limited 78910. FSH levels are easily influenced by gonadotropin-releasing hormone (GnRH), estradiol, and T. Testosterone and testicular volume cannot reflect the presence of focal spermatogenesis 711.…”

Section: Introductionmentioning

confidence: 99%

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men

et al. 2019

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The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52.85%). The haploid gamete group always had higher INHB levels than the non-haploid gamete group. According to the receiver operating characteristic (ROC) curve analysis, INHB was a good predictor of testicular haploid gamete retrieval outcome in all patients (sensitivity: 77.93% and specificity: 91.58%) and patients with normal follicle-stimulating hormone (FSH; sensitivity: 88.52% and specificity: 70.83%). The area under the ROC curve (AUC) of INHB was similar to that of FSH in all patients or patients with normal FSH. In patients with elevated FSH, INHB was superior to FSH in predicting the presence of haploid gamete (AUC: 0.73 vs 0.55, P < 0.05), with a sensitivity of 60.00% and a specificity of 80.28%. It concluded that serum INHB as an effective marker for spermatogenesis was a significant predictor of testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men. Especially, INHB is superior to FSH in predicting the presence of haploid gamete in the patients with elevated FSH.

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Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia: a systematic review and meta-analysis

Cited by 42 publications

References 27 publications

Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias

Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias

Analysis of factors affecting repeat microdissection testicular sperm extraction outcomes in infertile men

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men

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