Abstract:SummaryMore than a decade after the free-radical-theory of ovarian aging, researchers confirmed the importance of age-related oxidative threat to female fertility and moved to investigate the stress adaptive response in the ovarian follicle components. In this context a potential role for SIRT1, a NAD + -dependent deacetylase and key antiaging molecule, has arisen as guardian of the redox state and regulator of hormone secretion in the follicle. This review summarizes current knowledge on the role of this sirt… Show more
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