Folic Acid Use in Pregnancy and the Development of Atopy, Asthma, and Lung Function in Childhood

Magdelijns, Fabienne; Mommers, Monique; Penders, John; Smits, Luc; Thijs, Carel

doi:10.1542/peds.2010-1690

Cited by 109 publications

(165 citation statements)

References 29 publications

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“…Also, in the KOALA birth cohort [6], no associations were found between folic acid supplement use during the whole pregnancy and allergic and respiratory outcomes were found. In line with our results on sensitisation, large British and Dutch birth cohorts observed no association between maternal use of folic acid supplements at several moments during pregnancy and atopy (measured by skin-prick test) in the child at 7 yrs of age [6,14]. An increased risk was only observed in the subgroup of children carrying the T allele of the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene, if mothers took supplements at 32 weeks, but not if they took supplements at 18 weeks [14].…”

Section: Findings Of Other Studiesmentioning

confidence: 84%

“…In contrast to the Norwegian study, maternal folate intake from supplements in early pregnancy was not associated with increased risk in the Australian study, although the intakes of supplements were substantially higher in early pregnancy (median 667 mg per day) than in late pregnancy (median 300 mg per day). Similarly, two recent studies that focussed on folic acid supplement use in early pregnancy showed no associations with increased risk of asthma at ages 6 and 7 yrs [6,7]. Also, in the KOALA birth cohort [6], no associations were found between folic acid supplement use during the whole pregnancy and allergic and respiratory outcomes were found.…”

Section: Findings Of Other Studiesmentioning

confidence: 84%

“…Similarly, two recent studies that focussed on folic acid supplement use in early pregnancy showed no associations with increased risk of asthma at ages 6 and 7 yrs [6,7]. Also, in the KOALA birth cohort [6], no associations were found between folic acid supplement use during the whole pregnancy and allergic and respiratory outcomes were found. In line with our results on sensitisation, large British and Dutch birth cohorts observed no association between maternal use of folic acid supplements at several moments during pregnancy and atopy (measured by skin-prick test) in the child at 7 yrs of age [6,14].…”

Section: Findings Of Other Studiesmentioning

confidence: 84%

“…Two recent studies [6,7] emphasise the need to study these possible harmful effects in older children, as diagnosing asthma at an early age is difficult. We had the opportunity to investigate the effects of folic acid supplementation during pregnancy until the age of 8 yrs and investigate objective markers of asthma symptoms and atopy, i.e.…”

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confidence: 99%

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Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy

Bekkers¹,

Elstgeest²,

Scholtens³

et al. 2011

Eur Respir J

123

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Previous studies have suggested possible adverse side-effects of maternal use of folic acid-containing supplements (FACSs) during pregnancy on wheeze and asthma in early childhood. We investigated the association between maternal use of FACSs and childhood respiratory health and atopy in the first 8 yrs of life.Data on maternal use of FACSs, collected during pregnancy, were available for 3,786 children participating in the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. Questionnaire data on children's respiratory and allergic symptoms were collected annually and allergic sensitisation and bronchial hyperresponsiveness (BHR) were measured at 8 yrs of age.No overall (from 1 to 8 yrs of age) associations were observed between maternal use of FACSs and (frequent) asthma symptoms, wheeze, lower respiratory tract infection, frequent respiratory tract infection and eczema. Maternal folic acid use was associated with wheeze at 1 yr of age (prevalence ratio 1.20, 95% CI 1.04-1.39), but not with wheeze at later ages. Pre-natal exposure to FACSs was not associated with sensitisation and BHR.Apart from a small increased risk of early wheeze, we observed no adverse respiratory or allergic outcomes associated with pre-natal FACSs exposure in our study population.

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Section: Findings Of Other Studiesmentioning

confidence: 84%

Section: Findings Of Other Studiesmentioning

confidence: 84%

Section: Findings Of Other Studiesmentioning

confidence: 84%

mentioning

confidence: 99%

See 2 more Smart Citations

Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy

Bekkers¹,

Elstgeest²,

Scholtens³

et al. 2011

Eur Respir J

123

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“…Importantly, we reversed the immune phenotype by treatment with a demethylating agent (5-aza-deoxycytidine). Epidemiological evidence for association of folic acid with the development of asthma in children has been mixed [52][53][54][55][56], but it may be that folate together with other methyl donors in the diet plays a role in this disease.…”

Section: Dna Methylation and Asthma: Animal Studiesmentioning

confidence: 99%

Epigenetics and prenatal influences on asthma and allergic airways disease

Yang

2014

Breathe

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Epigenetics and prenatal influences on asthma and allergic airways disease IntroductionAsthma is a complex, heritable disease that has been increasing in prevalence, incidence and severity [1], although recent evidence suggests that the prevalence of asthma and allergies may have come to a plateau in developed countries [2]. Several separate lines of evidence support a role for epigenetics in asthma. First, asthma, like epigenetic mechanisms, is heritable. While asthma is a strongly familial condition (36-79% heritability) with a non-Mendelian pattern of inheritance and polymorphisms in more than 100 genes [3-6], these associations have infrequently been replicated and genetics has explained only a small portion of the aetiology of this disease [4]. Second, asthma, like epigenetic mechanisms, shows a parentof-origin transmission of inheritance with an affected mother significantly more likely to transmit the disease than an affected father [7]. These parent-of-origin effects may result from immune interactions between the fetus and the mother [8]. Alternatively, the maternal effect may be the result of epigenetically regulated genomic imprinting [9]. Several known genes show parent-of-origin effects on allergic disease; these genes include the FceRI-b locus [10], and the Spink5 gene [11]. Third, asthma, like epigenetic mechanisms [12,13], is affected by in utero exposures HERMES syllabus link: modules A.1, B.6 Statement of InterestNone declared.

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Folic Acid Supplementation for the Prevention of Neural Tube Defects

Viswanathan

Treiman

Kish-Doto

et al. 2017

JAMA

137

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Folic Acid Use in Pregnancy and the Development of Atopy, Asthma, and Lung Function in Childhood

Abstract: Our results do not confirm any meaningful association between folic acid supplement use during pregnancy and atopic diseases in the offspring. Higher ICF levels in pregnancy tended, at most, toward a small decreased risk for developing asthma.

Cited by 109 publications

References 29 publications

Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy

Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy

Epigenetics and prenatal influences on asthma and allergic airways disease

Folic Acid Supplementation for the Prevention of Neural Tube Defects

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