Folic acid-targeted pluronic F127 micelles improve oxidative stress and inhibit fibrosis for increasing AKI efficacy

Du, Bin; Zhao, Mengmeng; Wang, Yuehua; Yu, Lili; Jiao, Qingqing; Bai, Yimeng; Cheng, Genyang

doi:10.1016/j.ejphar.2022.175131

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…Third, increasing attention has been given to the protective role of curcumin in ischemia‒reperfusion injury in animal models and various organs [ 160 ]. In addition, curcumin has shown promise in the treatment of many other ROS-induced inflammatory diseases, including AKI [ 161 ], ALI [ 162 ], and ankle inflammation [ 151 ].…”

Section: Ros Scavenging Biomaterials In the Treatment Of Inflammationmentioning

confidence: 99%

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Liu,

Han,

Zhang

et al. 2023

J Hematol Oncol

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Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses is associated with most human diseases. Reactive oxygen species (ROS) are a class of chemicals that are generated after the incomplete reduction of molecular oxygen. At moderate levels, ROS function as critical signaling molecules in the modulation of various physiological functions, including inflammatory responses. However, at excessive levels, ROS exert toxic effects and directly oxidize biological macromolecules, such as proteins, nucleic acids and lipids, further exacerbating the development of inflammatory responses and causing various inflammatory diseases. Therefore, designing and manufacturing biomaterials that scavenge ROS has emerged an important approach for restoring ROS homeostasis, limiting inflammatory responses and protecting the host against damage. This review systematically outlines the dynamic balance of ROS production and clearance under physiological conditions. We focus on the mechanisms by which ROS regulate cell signaling proteins and how these cell signaling proteins further affect inflammation. Furthermore, we discuss the use of potential and currently available-biomaterials that scavenge ROS, including agents that were engineered to reduce ROS levels by blocking ROS generation, directly chemically reacting with ROS, or catalytically accelerating ROS clearance, in the treatment of inflammatory diseases. Finally, we evaluate the challenges and prospects for the controlled production and material design of ROS scavenging biomaterials.

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Section: Ros Scavenging Biomaterials In the Treatment Of Inflammationmentioning

confidence: 99%

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Liu,

Han,

Zhang

et al. 2023

J Hematol Oncol

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Dual-targeted nanoparticles with removing ROS inside and outside mitochondria for acute kidney injury treatment

Zhao,

Guo,

Tian

et al. 2024

Nanomedicine: Nanotechnology, Biology and Medicine

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Ultrasmall magnolol/ebselen nanomicelles for preventing renal ischemia/reperfusion injury

Liu,

Li,

et al. 2024

Biomater. Sci.

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Folic acid-targeted pluronic F127 micelles improve oxidative stress and inhibit fibrosis for increasing AKI efficacy

Cited by 5 publications

References 42 publications

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Dual-targeted nanoparticles with removing ROS inside and outside mitochondria for acute kidney injury treatment

Ultrasmall magnolol/ebselen nanomicelles for preventing renal ischemia/reperfusion injury

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