Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Loureiro, Ana; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, Marisa P.; Nogueira, E.; Preto, Ana; Gomes, Andreia C.; Cavaco-Paulo, Artur

doi:10.1016/j.nano.2015.02.022

Cited by 32 publications

(22 citation statements)

References 31 publications

(30 reference statements)

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“…In addition, the surface modification of nanoparticles is feasible for the goal of active targeting . Folic acid‐functionalized protein nanoemulsions loaded with CORM‐2 were found to be preferentially internalized in folate receptor‐positive lymphoma cell lines (A20 cell lines), leading to a considerable antiproliferative function and increasing the survival of BALB/c mice bearing A20 lymphoma tumors …”

Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

“…On the other hand, nanomaterials can be used as targeted CORMs delivery and controllable CO release . The EPR effect and active targeting effect of nanomaterials are feasible for the enrichment of low molecular weight CORMs at the disease site . This can greatly improve the biodistribution and bioavailability of bare CORMs, and minimize their side‐effects in healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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“…Although some marginal cytotoxicity, though not relevant, was noted, studies indicate that BSA/Pol 407 particles are safe to use even in vivo with animals not developing any adverse reaction or losing weight or compromising survival (Loureiro et al 2015a).…”

Section: Discussionmentioning

confidence: 96%

Albumin/asparaginase capsules prepared by ultrasound to retain ammonia

Tinoco

Ribeiro

Oliveira

et al. 2016

Appl Microbiol Biotechnol

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Asparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia. The accumulation of ammonia in the bloodstream leads to hyperammonemia, described as one of the most significant side effects of asparaginase therapy. Therefore, there is a need for asparaginase formulations with the potential to reduce hyperammonemia. We incorporated 2 % of therapeutic enzyme in albumin-based capsules. The presence of asparaginase in the interface of bovine serum albumin (BSA) capsules showed the ability to hydrolyze the asparagine and retain the forming ammonia at the surface of the capsules. The incorporation of Poloxamer 407 in the capsule formulation further increased the ratio aspartic acid/ammonia from 1.92 to 2.46 (and 1.10 from the free enzyme), decreasing the levels of free ammonia. This capacity to retain ammonia can be due to electrostatic interactions and retention of ammonia at the surface of the capsules. The developed BSA/asparaginase capsules did not cause significant cytotoxic effect on mouse leukemic macrophage cell line RAW 264.7. The new BSA/asparaginase capsules could potentially be used in the treatment of acute lymphoblastic leukemia preventing hyperammonemia associated with acute lymphoblastic leukemia (ALL) treatment with asparaginase.

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“…Furthermore, tagged nanoemulsions containing CORM‐2 for targeted B‐cell lymphoma treatment in in vitro and in vivo experiments proved to be efficient (Loureiro et al . ). Nevertheless, CO administration for cancer treatment is not trivial, since up‐regulation of HO‐1 was already observed in several human and murine cancer types and linked to their intrinsic resistance (Yin et al .…”

Section: Biology Of Carbon Monoxidementioning

confidence: 97%

Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism – a role for Ca²⁺?

Oliveira

Queiroga

Vieira

2015

The Journal of Physiology

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Carbon monoxide (CO) is an endogenously produced gasotransmitter with important biological functions: anti‐inflammation, anti‐apoptosis, vasomodulation and cell metabolism modulation. The most recognized cellular target for CO is the mitochondria. Physiological concentrations of CO generate mitochondrial reactive oxygen species (ROS), which are signalling molecules for CO‐induced pathways. Indeed, small amounts of ROS promote cytoprotection by a preconditioning effect. Furthermore, CO prevents cell death by limiting mitochondrial membrane permeabilization, which inhibits the release of pro‐apoptotic factors into the cytosol; both events are ROS dependent. CO also increases the ability of mitochondria to take up Ca2+. Mitochondrial metabolism is modulated by CO, namely by increasing TCA cycle rate, oxidative phosphorylation and mitochondrial biogenesis, which, in turn, increases ATP production. CO's modulation of metabolism might be important for cellular response to diseases, namely cancer and ischaemic diseases. Finally, another cytoprotective role of CO involves the control of Ca2+ channels. By limiting the activity of T‐type and L‐type Ca2+ channels, CO prevents excitotoxicity‐induced cell death and modulates cell proliferation. Several questions concerning Ca2+ signalling, mitochondria and CO can be asked, for instance whether CO modulation of cell metabolism would be dependent on the mitochondrial Ca2+ uptake capacity, since small amounts of Ca2+ can increase mitochondrial metabolism. Whether CO controls Ca2+ communication between mitochondria and endoplasmic reticulum is another open field of research. In summary, CO emerges as a key gasotransmitter in the control of several cellular functions of mitochondria: metabolism, cell death and Ca2+ signalling.

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Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Cited by 32 publications

References 31 publications

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Albumin/asparaginase capsules prepared by ultrasound to retain ammonia

Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism – a role for Ca²⁺?

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Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Cited by 32 publications

References 31 publications

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Albumin/asparaginase capsules prepared by ultrasound to retain ammonia

Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism – a role for Ca2+?

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Product

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Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism – a role for Ca²⁺?