Folic acid supplements in pregnancy and early childhood respiratory health

Håberg, Siri E.; London, Stephanie J.; Stigum, Hein; Nafstad, Per; Nystad, Wenche

doi:10.1136/adc.2008.142448

Cited by 235 publications

(219 citation statements)

References 24 publications

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“…This finding underscores the need for continued promotion of universal provision of folate for all pregnancy women. However, other few studies revealed that taking folate would lead to childhood asthma [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of Maternal Nutrition and Dietary Habits on Preeclampsia: A Case-Control Study

Endeshaw¹,

Ambaw²,

Aragaw³

et al. 2014

IJCM

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Introduction: Preeclampsia is one of the most commonly encountered hypertensive disorders of pregnancy that accounts for 20% -80% of maternal mortality in developing countries, including Ethiopia. For many years diet has been suggested to play a role in preeclampsia. However, the hypotheses have been diverse and often revealed inconsistent results across studies. Moreover, rarely were these hypotheses studied in Ethiopia. Therefore, this study aimed to explore whether the incidence of preeclampsia was related to nutrient or micronutrient deficiencies. Objectives: To describe the effect of nutrition and dietary habits on the incidence of preeclampsia. Methods: A facility based unmatched case-control study was conducted among 453 (151 cases and 302 controls) pregnant women attending antepartum or intrapartum care in public health facilities of Bahir Dar City Administration. Case-control incidence density sampling followed by interviewer administered face to face interview, measurement of mid-arm circumference (MUAC) and document review were conducted using a standardized and pretested questionnaire. Data entry and cleaning was done by Epi Info Version 3.5.3. The data were transported to SPSS Version 20 for analysis. Both bivariate and multivariate logistic regression analyses were applied. Backward stepwise unconditional logistic regression analysis was employed to determine the putative association of predictive variables with the outcome variable and to control for the effect of confounding variables. A P-value ≤ 0.05 was considered statistically significant at 95% confidence level throughout the study. Result: Those women having a MUAC value ≥ 25.6 cm were two times more likely than their counterparts to have preeclampsia (AOR = 2.49, 95% CI = 1.58, 3.94). Strikingly, higher odds of preeclampsia were found in women who reported to have taken coffee during pregnancy (AOR = 2.16, 95% CI = 1.32, 3.53). Similarly, those women who had anemia during the first trimester pregnancy were three times more likely than their counterparts to have incidence of M. Endeshaw et al. 1406 preeclampsia (AOR = 2.80, 95% CI = 1.09, 7.21). The result in this study also revealed that taking fruit or vegetables during pregnancy was found to be protective of preeclampsia (AOR = 0.37, 95% CI = 0.19, 0.73, AOR = 0.45, 95% CI = 0.22, 0.91) respectively. In addition, folate intake during pregnancy has shown a significant independent effect on the prevention of preeclampsia in this study (AOR = 0.19, 95% CI = 0.10, 0.37). Conclusion and Recommendation: Vegetable and fruit consumption and folate intake during pregnancy are independent protective factors of preeclampsia. On the other hand, higher mid upper arm circumference, anemia and coffee intake during pregnancy are risk factors for the development of preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Effect of Maternal Nutrition and Dietary Habits on Preeclampsia: A Case-Control Study

Endeshaw¹,

Ambaw²,

Aragaw³

et al. 2014

IJCM

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“…[66]], vitamin D [reviewed in ref. [67,68]] and folate [69,70]. Vitamin D (table 3) has been attracting increasing attention due to the recent epidemiologic studies from Australia and the US that reported an association between the lower exposure to sunlight/UVB in the northern areas and anaphylaxis in children [71,72,73].…”

Section: Pathways and Target Candidates For Prevention Strategiesmentioning

confidence: 99%

Strategies to Prevent or Reduce Allergic Disease

Prescott

Nowak‐Węgrzyn

2011

Ann Nutr Metab

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The need for allergy prevention strategies has never been greater. Surging rates of food allergy and eczema are now adding to the already substantial burden of asthma and respiratory allergic diseases. The parallel rise in many other immune diseases suggests that the developing immune system is highly vulnerable to modern environmental changes. These strong environmental pressures may be one reason why simple allergen avoidance strategies have not been successful. Another more recent strategy to curtail the allergy epidemic has been to identify factors associated with modern lifestyle that may be causally linked with allergic disease, in an attempt to restore more favourable conditions for immune tolerance during early development. More hygienic conditions and disruption of microbial exposure have prompted strategies to restore this balance using probiotic and prebiotic supplements. Modern dietary changes linked with allergic diseases have prompted supplementation studies to assess the preventive merits of specific immunomodulatory dietary nutrients such as polyunsaturated fatty acids. Other nutrients such as antioxidants, folate, and vitamin D are also currently under investigation. Modern environmental pollutants have also been associated with adverse effects on immune development and the risk of disease. While many of these avenues have provided some promise, they have not yet translated into specific recommendations. Current evidence-based guidelines for allergy prevention remain limited to avoidance of cigarette smoke, promotion of breastfeeding and the use of hydrolysed formula when breastfeeding is not possible. Allergen avoidance strategies have been largely removed from most guidelines. It is hoped that a number of ongoing studies will help provide clearer recommendations around the use of probiotics, prebiotics, specific dietary nutrients and the role of early introduction of allergenic foods for the promotion of tolerance. Despite the current uncertainties, prevention remains the best long-term strategy to reduce the growing burden of allergic disease.

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“…[25][26][27][28][29][30][31] Extremes of the birth weight distribution have been associated with a wide range of childhood and adultonset chronic diseases and conditions including obesity, impaired glucose tolerance, type 2 diabetes, coronary artery disease, congestive heart failure and some cancers. [32][33][34][35][36] Periconceptional and perinatal exposure to FA supplements has also been linked to wheezing in mice 37 and humans, 38 as well as childhood asthma.…”

Section: Introductionmentioning

confidence: 99%