Folic acid supplementation use among women who contact a teratology information service

Tolosa, Jorge E.; Lewis, Dawnette; Myers, Victoria; Royds, Cynthia; Sabogal, Juan Carlos; Librizzi, R.

doi:10.1067/mob.2002.126981

Cited by 10 publications

(7 citation statements)

References 3 publications

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“…A comparison with the results of the most recent March of Dimes survey (CDC, 2005) indicated that the prevalence of periconceptional supplement use among CTIS respondents (44%) was higher than that reported in the nationally representative sample (33%). Similar to previous findings, there were differences in supplement use by race/ethnicity as well as other previously recognized risk factors, such as younger maternal age, lower educational level, and unplanned pregnancy (CDC, , 1999(CDC, , 2005Feldkamp et al, 2002;Ahluwalia and Daniel, 2001;Dawson et al, 2001;Perlow, 2001;Stepanuk et al, 2002).…”

Section: Discussionsupporting

confidence: 84%

Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: Survey results from a Teratogen Information Service

Goldberg

Alvarado

Chavez

et al. 2006

Birth Defects Research

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Section: Discussionsupporting

confidence: 84%

Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: Survey results from a Teratogen Information Service

Goldberg

Alvarado

Chavez

et al. 2006

Birth Defects Research

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“…In 29 studies (56%), folic acid use was assessed based on interviews, while in 20 studies (38%) self‐administered questionnaires were used (Table 1). The surveys were conducted in variety of Western and Eastern countries, between 1992 9 and 2001 57–61 (Table 1). Most studies were conducted in an outpatient setting, usually at an early antenatal visit [ n = 22 (42%)] or at 18‐week obstetric ultrasound [ n = 4 (7.7%)].…”

Section: Resultsmentioning

confidence: 99%

Evidence for suboptimal use of periconceptional folic acid supplements globally

Ray

Singh

Burrows

2004

BJOG

130

128

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Objective To systematically summarise the available evidence concerning the rate of folic acid supplement use pre-and periconceptionally, to identify those characteristics associated with low rates of use and to assess whether folic acid public awareness campaigns are associated with higher folic acid use. Design Systematic overview.Setting Survey studies.Population Women of reproductive age, most of whom were currently or recently pregnant.Methods Two investigators searched MEDLINE, Embase and Nutriotiongate databases between 1990 and 2003. Bibliographies of retrieved references were scanned for other relevant publications, and authors were contacted if necessary. Studies were included that evaluated the rate of folic acid supplement use either before conception or in early pregnancy. Main outcome measures Rate of preconceptional and/or periconceptional folic acid use, rate of planned pregnancy in each study, as well as significant characteristics differentiating non-users from users of folic acid, including the effect of folic acid awareness campaigns. Results A total of 52 studies were included. In 34 studies, reported preconceptional folic acid use varied from 0.9% to 50%. In 49 studies, the reported rate of periconceptional supplement use ranged from 0.5% to 52%. Significant predictors of reduced periconceptional folic acid use were a low level of formal education, immigrant status, young maternal age, lack of a partner and an unplanned pregnancy. Four studies examined the effect of mass media campaigns on periconceptional folic acid use; the reported rates increased significantly, by a factor of 1.7 to 7.2, but in no study was the post-campaign rate above 50%. Conclusions In many countries, fewer than 50% of women take periconceptional folic acid supplements.Consideration should be given to the practical advantages of folic acid fortification of centrally processed foods, such as wheat, corn and rice flour, while further promoting vitamin tablet supplement use and planned pregnancy.

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“…A Organização Mundial da Saúde (OMS) recomenda a ingestão diária de 0,4 mg de ácido fólico para todas as mulheres em idade fértil devido ao grande número de gestações não-planejadas (1,20) . Isso pode ser obtido por utilização de suplementos de ácido fólico, seleção de alimentos ricos em folato ou consumo de alimentos fortificados (7) , sendo que este último mostrou ser a maneira mais efetiva (13) .…”

Section: Introductionunclassified

Sacarose como veículo de suplementação dietética de ácido fólico em camundongos prenhes

Lima

Gutierrez

Yanaguita

et al. 2009

J. Bras. Patol. Med. Lab.

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Introdução: A ingestão adequada de folato é essencial durante a embriogênese, e sua deficiência está associada à ocorrência de defeitos no fechamento do tubo neural. Objetivo: Determinar se a sacarose é um bom veículo para a suplementação de folato em camundongos. Materiais e métodos: Quarenta camundongos Swiss fêmeas foram divididos nos grupos: C: ração comercial + água ad libitum; DS: ração balanceada isenta de folato + folato adicionado à sacarose diluída na água por 14 dias; D/DS: ração balanceada isenta de folato + água com sacarose sem folato por 14 dias seguida de ração balanceada isenta de folato + folato adicionado à sacarose diluída na água por mais 14 dias; D: ração balanceada isenta de folato + água com sacarose sem folato por 14 dias. Os animais de todos os grupos experimentais receberam ração balanceada isenta de folato + folato adicionado à sacarose diluída na água durante os três dias do acasalamento e nos 15 dias restantes até o sacrifício. Resultados: Os animais dos grupos D e D/DS apresentaram alopecia, palidez ocular e adinamia enquanto consumiam água com sacarose sem folato, sinais que foram revertidos quando receberam folato adicionado à sacarose diluída na água. Não houve diferença entre os grupos em relação a prenhez, implantes, fetos vivos, reabsorção, morte fetal tardia, nível sérico de folato e contagem de hemácias ao final do experimento, não tendo sido observadas anomalias congênitas em nenhum dos grupos. Conclusão: A sacarose é um meio adequado para a suplementação de folato na dieta. abstract resumoAdequate folate intake is essential during embryogenesis and its deficiency is associated with neural tube defects. Objective: To investigate if saccharose is a good vehicle for the supplementation of folate in mice. Materials and methods: 40 Swiss female mice were allocated into the following groups: C (commercial mouse food + ad libitum water); DS (folate-free balanced diet + saccharose with folate diluted in water for 14 days); D/DS (folate-free balanced diet + folate-free saccharose diluted in water for 14 days, followed by folate-free balanced diet + saccharose with folate diluted in water for 14 days); D (folate-free balanced diet + folate-free saccharose diluted in water for 14 days). Mice from all experimental groups received folate-free balanced diet + saccharose with folate diluted in water during their three-day mating period and thereafter 15 days until animals were put down. Results: Mice from groups D and D/DS showed alopecia, pale eyes and adynamia while on folate-free saccharose water regimen. These symptoms disappeared after the introduction of saccharose with folate diluted in water. No statistical difference was noted among groups as to pregnancy, number of implants, live fetuses, reabsorption, late fetal death, serum folate levels and red blood cells count and no congenital abnormalities were identified in any groups by the end of the experiment. Conclusion: Saccharose is a suitable vehicle for the dietary supplementation of folate. unitermos key words Sacarose Ácido f...

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Folic acid supplementation use among women who contact a teratology information service

Cited by 10 publications

References 3 publications

Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: Survey results from a Teratogen Information Service

Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: Survey results from a Teratogen Information Service

Evidence for suboptimal use of periconceptional folic acid supplements globally

Sacarose como veículo de suplementação dietética de ácido fólico em camundongos prenhes

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