Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial

Abstract

This study suggests that supplementation with FA during long-term MTX treatment reduces the efficacy of MTX in the control of psoriasis. Due to the relatively small sample size and short duration of this study, no conclusions can be drawn regarding the possibility that FA may reduce the side-effects of MTX.

Poor Reporting of Quality of Life Outcomes in Dermatology Randomized Controlled Clinical Trials

“…The remaining 67 articles satisfied our criteria [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. Sixteen concerned atopic dermatitis [7, 13, 14, 18,20,21,22, 26, 29, 31, 42, 46, 56, 66, 67, 70], 1 chronic eczema of the hands [9], 25 psoriasis [10, 17, 27, 30, 33,35,36,37,38,39,...…”

“…In 16 of them, trial results were published in several different articles, one relating the QOL findings and the other(s) the clinical outcomes [7, 9, 18,28,29,30, 33, 34, 40, 44, 51, 55, 57, 59, 67, 72]. Nine percent (6/67) of the retained trials justified the choice of a general or specific questionnaire and the rationale for using several questionnaires [23, 33, 40, 44, 48, 71]. …”

“…the number of dimensions and their contents, such as the number of items per dimension, and the minimal and maximal scores [9, 15, 20, 33, 39, 40, 43, 44, 51, 57, 58, 65, 69]. Only the name of the questionnaire was given in 16 others [12, 18, 19, 21, 25, 31, 32, 38, 45, 46, 53, 54, 61, 64, 66, 71]. In the remaining articles, this information was partially reported.…”

Current Status of Folic Acid Supplementation on Colorectal Cancer Prevention

“…These include masking of vitamin B 12 deficiency primarily in elderly [58]; decreased natural killer cell cytotoxicity [56]; resistance to antifolate drugs used against arthritis [59][60][61], malaria [62], and cancer [63,64]; an increased risk of insulin resistance and obesity and asthma in children born to folic acid-supplemented mothers [65]; accelerated progression of diabetic nephropathy [66]; an increased risk of cognitive impairment in elderly with suboptimal vitamin B 12 status [67,68]; aberrant patterns and dysregulation of DNA methylation [69]; and the promotion of progression of existing precancerous lesions or cancer [1,2,15,16].…”

Psoriatic flare after the concomitant administration of L-methylfolate and methotrexate

“…Some studies, however, indicate that this combination may be associated with decreased efficacy of methotrexate. [3][4][5][6][7] L-methylfolate (Deplin Nestle Health Science; Pam Lab Inc, Covington, Louisiana) is a relatively new medical food used as an adjunctive therapy for treatment of depression. The mechanism of action is that L-methylfolate, the biologically active form of folate, is the only metabolite of folate that crosses the bloodebrain barrier where it regulates the formation of the cofactor tetrahydrobiopterin (BH4), which is necessary for the synthesis of serotonin, dopamine, and norepinephrine.…”