Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study

Strandhagen, Elisabeth; Landaas, Sverre; Thelle, Dag S.

doi:10.1038/sj.ejcn.1601703

Cited by 20 publications

(15 citation statements)

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“…Another study by the same group (10 ) suggested that the additional rise in homocysteine for coffee drinkers could be due to the chlorogenic acid content of coffee, perhaps through its metabolism by methylation, which leads to increased homocysteine production (40 ). Both of these mechanisms are compatible with the observation that folate supplementation prevented the increase in tHcy following coffee consumption (11 ).…”

Section: The Increase In Thcysupporting

confidence: 68%

“…Thus, the mechanism behind the tHcy increase is uncertain, although caffeine, as well as chlorogenic acid, a polyphenol found in large quantities in coffee, were shown to increase tHcy (8,10 ). Moreover, the addition of 200 g/day of folic acid to coffee intervention groups prevented the increase in tHcy (11 ).…”

confidence: 99%

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Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

et al. 2008

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Background: Coffee consumption has been associated with several risk factors for coronary heart disease, including increased cholesterol, increased blood pressure, and increased plasma total homocysteine (tHcy). tHcy is determined by several B-vitamins. However, reports about the association between coffee intake and B-vitamin status are few. Methods: We measured plasma B-vitamins and tHcy in a cohort of 10 601 healthy, middle-aged Norwegian men and women. Information about lifestyle factors, including coffee consumption, smoking, alcohol use, height, and weight, was obtained by interview. Results: Coffee consumption was dose-dependently associated with reduced plasma B-vitamin concentrations. Compared with coffee abstainers, individuals drinking ≥4 cups/day had 11.7% (P < 0.001), 14.1% (P < 0.001), and 5.5% (P = 0.01) lower plasma concentrations of folate, pyridoxal phosphate, and riboflavin, respectively, and the mean tHcy concentration was 6.8% (P < 0.001) higher. Quantile regression analysis showed essentially no difference in B-vitamin concentrations between coffee consumption categories at low vitamin concentrations but a progressive increase in the difference at higher concentrations. This pattern of differences (effect profile) was found independently of smoking status, alcohol intake, and sex. The decrease in folate explained approximately half of the increase in tHcy. Conclusions: Coffee consumption was associated with reduced circulating B-vitamin concentrations. The observed effect profiles indicated that coffee consumption preferentially affected the upper, but not the lower, part of the B-vitamin concentration distributions. We hypothesize that coffee consumption may increase the loss of surplus B-vitamins by excretion in urine.

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Section: The Increase In Thcysupporting

confidence: 68%

confidence: 99%

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

et al. 2008

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“…However, the effects of some of the lifestyle factors have been confirmed in randomized controlled trials (van der Gaag et al, 2000;Stein et al, 2002;Strandhagen et al, 2003), although not in all (Wright et al, 1998;Bleich et al, 2001;Tonstad and Urdal, 2002;Duncan et al, 2004;Beulens et al, 2005). Especially the results from trials examining the Simple regression models were adjusted for follow-up time, baseline values of homocysteine, and baseline value of the biological marker.…”

Section: Discussionmentioning

confidence: 99%

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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Background: Reduction in total homocysteine (tHcy) may be clinically relevant in the prevention of cardiovascular disease (CVD) in the general population. Objective: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype. Design: A 1 year follow-up study. Setting: Copenhagen County, Denmark. Subjects: Statistical analyses were based on a population-based sample of 915 men and women aged 30-60 years assessed to be at increased CVD risk at baseline and therefore offered lifestyle intervention and re-examination after one year. Results: None of the studied lifestyle changes -smoking, physical activity, dietary habits, and coffee, tea, and alcohol consumption -was significantly associated with changes in tHcy, either overall, or in any of the MTHFR genotype subgroups. In addition, changes in tHcy did not differ between participants randomized to low-and high-intensity lifestyle intervention. However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed. In addition, changes in tHcy were associated with changes in several of the biological CVD risk markers: weight, total cholesterol, HDL cholesterol, LDL cholesterol and systolic blood pressure. Conclusions: Our results indicate that tHcy may not be reduced by lifestyle changes; additionally, they suggest that tHcy may be related to biological CVD risk markers through a lifestyle independent pathway.

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“…Adjusting for different possible confounders did not alter the result. The study by Strandhagen et al also showed that 4 cups of filtered coffee had an effect on plasma homocysteine, by 1 mmol l (1 (96). Until recently, no plausible mechanism was known to explain the homocysteine-raising effect of coffee, but a recent observational study showed a positive association between caffeine intake and homocysteine concentrations (90).…”

Section: Coffee and Serum Cholesterolmentioning

confidence: 99%

Coffee and disease: an overview with main emphasis on blood lipids and homocysteine

Thelle¹,

Strandhagen²

2005

Food & Nutrition Research

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The issue of whether coffee is detrimental or beneficial to health has been studied in a large number of observational and clinical studies. Some observational studies have shown an association between coffee and coronary heart disease (CHD), while others have not. Both clinical trials and observational studies have shown that coffee consumption affects some CHD risk factors, e.g. plasma total homocysteine and serum total cholesterol. Studies on the association between coffee consumption and health have shown protective effects against type 2 diabetes, Parkinson's disease and Alzheimer's disease, whereas the protective effect against certain forms of cancer and possible hazards with regard to reproductive health are still debated. This review reports on the association between coffee intake and homocysteine and blood lipids in light of the results of studies by this group. A review of published papers on the relevant issues found that protective effects of coffee have been reported for type 2 diabetes, Parkinson's disease and Alzheimer's disease. These results are based on observational studies. More studies with adequate control of confounding variables are needed to confirm these findings. There are at present no relevant biological explanations for any protective effect. Studies by this group have confirmed that even filtered coffee has a total cholesterol-increasing effect. Whether this is due to changes in filter-paper quality or other unknown mechanisms is not clear. The homocysteine-raising effect of coffee is mainly seen among subjects with the methylenetetrahydrofolate reductase (MTHFR) 677TT polymorphism, demonstrating a nutrition Á/gene effect modification. In conclusion, the effects of coffee on blood lipids and plasma homocysteine are firmly based, but the studies reflect a certain heterogeneity, in part explained by genetic susceptibility. The coffee Á/health issue is still pending; there are certain firmly established biological effects of coffee intake, but the impact on future health is virtually unknown.

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Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study

Cited by 20 publications

References 38 publications

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Coffee and disease: an overview with main emphasis on blood lipids and homocysteine

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