Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats

Liu, Huan; Cao, Jiasong; Zhang, Haihong; Qin, Shanchun; Yu, Min; Zhang, Xumei; Wang, Xuan; Gao, Yuxia; Wilson, John X.; Huang, Guowei

doi:10.1016/j.jnutbio.2013.04.002

Cited by 25 publications

(17 citation statements)

References 18 publications

(20 reference statements)

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“…[ 32 ]. The remaining studies performed temporary occlusion, which ranged from 5 minutes [ 13 , 16 , 31 ] to 120 minutes [ 24 , 25 , 28 ]. The most common vascular beds used were the middle cerebral artery as well as the internal carotid artery of rabbits (New Zealand) [ 12 , 34 ] and the common carotid artery of rats [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…[ 16 ] (2013) Mice (CD-1) MCDA T (5 mi) In lab 5-33 Mice NSC 5 × 10 5 IC; V 1 d N/A N/A Liu et al . [ 31 ] (2013) Rat (Sprague-Dawley) MCDA T (5 mi) In lab N/A Rat NSC 3 × 10 4 Str 2 d N/A N/A Lu et al . [ 11 ] (2013) Dog (Beagle) MCDA T (2 h) In lab N/A Dog (bone marrow) MSC 3 × 10 6 IC 2 h N/A N/A Kamiya et al .…”

Section: Resultsmentioning

confidence: 99%

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Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

et al. 2015

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IntroductionAlthough there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best cell type to be used, the best route, and also the best nanoparticle to analyze these stem cells in vivo. This review analyzed published data on superparamagnetic iron oxide nanoparticle (SPION)-labeled stem cells used for ischemic stroke therapy.MethodWe performed a systematic review and meta-analysis of data from experiments testing the efficacy of cellular treatment with SPION versus no treatment to improve behavioral or modified neural scale outcomes in animal models of stroke by the Cochrane Collaboration and indexed in EMBASE, PubMed, and Web of Science since 2000. To test the impact of study quality and design characteristics, we used random-effects meta-regression. In addition, trim and fill were used to assess publication bias.ResultsThe search retrieved 258 articles. After application of the inclusion criteria, 24 reports published between January 2000 and October 2014 were selected. These 24 articles were analyzed for nanoparticle characteristics, stem cell types, and efficacy in animal models.ConclusionThis study highlights the therapeutic role of stem cells in stroke and emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

et al. 2015

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“…Folate deficiency suppressed the proliferation of adult hippo-campal NSPCs in vivo and of embryonic NSPCs in vitro [87]. NSPCs respond to folate with altered Notch signaling, increased cell proliferation [88, 89] and increased neuronal differentiation by enhancing the activity of DNA methyl-transferases (DNMTs) [90, 91]. These reports suggest that one-carbon metabolism may play a critical role in NSPC fate as DNMT maintains progenitor function in self-renewing somatic tissue [92].…”

Section: Metabolic Pathways In Neural Stem Cellsmentioning

confidence: 99%

Metabolic circuits in neural stem cells

Kim

Rhee

Paik

2014

Cell. Mol. Life Sci.

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Metabolic activity indicative of cellular demand is emerging as a key player in cell fate decision. Numerous studies have demonstrated that diverse metabolic pathways have a critical role in the control of the proliferation, differentiation and quiescence of stem cells. The identification of neural stem/progenitor cells (NSPCs) and the characterization of their development and fate decision process have provided insight into the regenerative potential of the adult brain. As a result, the potential of NSPCs in cell replacement therapies for neurological diseases is rapidly growing. The aim of this review is to discuss the recent findings on the crosstalk among key regulators of NSPC development and the metabolic regulation crucial for the function and cell fate decisions of NSPCs. Fundamental understanding of the metabolic circuits in NSPCs may help to provide novel approaches for reactivating neurogenesis to treat degenerative brain conditions and cognitive decline.

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“…We use the following external resources: (i) Panther (16), from which we build <GeneID, GOSlimID> pairs; (ii) iProClass (9), from which we obtain <GOSlimID, GOID, PMID> triplets; (iii) a collection of PMC full-text articles that serve as the source for finding relevant documents and (iv) a collection of PubMed abstracts, used as a complementary source for retrieving, because for some GOA records, only abstracts are publically available for the corresponding articles.…”

Section: System Descriptionmentioning

confidence: 99%

Integrating information retrieval with distant supervision for Gene Ontology annotation

Zhu

Carterette

et al. 2014

Database

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This article describes our participation of the Gene Ontology Curation task (GO task) in BioCreative IV where we participated in both subtasks: A) identification of GO evidence sentences (GOESs) for relevant genes in full-text articles and B) prediction of GO terms for relevant genes in full-text articles. For subtask A, we trained a logistic regression model to detect GOES based on annotations in the training data supplemented with more noisy negatives from an external resource. Then, a greedy approach was applied to associate genes with sentences. For subtask B, we designed two types of systems: (i) search-based systems, which predict GO terms based on existing annotations for GOESs that are of different textual granularities (i.e., full-text articles, abstracts, and sentences) using state-of-the-art information retrieval techniques (i.e., a novel application of the idea of distant supervision) and (ii) a similarity-based system, which assigns GO terms based on the distance between words in sentences and GO terms/synonyms. Our best performing system for subtask A achieves an F1 score of 0.27 based on exact match and 0.387 allowing relaxed overlap match. Our best performing system for subtask B, a search-based system, achieves an F1 score of 0.075 based on exact match and 0.301 considering hierarchical matches. Our search-based systems for subtask B significantly outperformed the similarity-based system.Database URL: https://github.com/noname2020/Bioc

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Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats

Cited by 25 publications

References 18 publications

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

Metabolic circuits in neural stem cells

Integrating information retrieval with distant supervision for Gene Ontology annotation

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