Folic acid-modified curcumin-loaded liposomes for breast cancer therapy

Luiz, Marcela Tavares; Dutra, Jessyca Aparecida Paes; Ribeiro, Taís de Cássia; Carvalho, Gabriela Corrêa; Sábio, Rafael Miguel; Marchetti, Juliana Maldonado; Chorilli, Marlus

doi:10.1016/j.colsurfa.2022.128935

Cited by 22 publications

(5 citation statements)

References 68 publications

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“…For this purpose, MCF-7 spheroids were obtained using the liquid overlay technique and were used to compare the viability and cellular uptake induced by curcumin alone (CCM), liposomes loaded with curcumin (LIP-CCM) and FA-modified liposomes loaded with curcumin (FA-LIP-CCM). These results proved not only the limitations of two-dimensional systems for drug testing, but also the importance of folic acid functionalization for active targeting [ 136 ]. Similarly, T7 peptide was used by Riaz et al for functionalizing liposomes for the active targeting of the transferrin receptor and loaded with quercetin to act as a chemotherapeutic agent against lung cancer 3D models [ 137 ].…”

Section: 3d Cultures Studies and Perspectivesmentioning

confidence: 92%

“…Specifically, cancer spheroids have been employed as tools to test various active-targeting approaches. Tavares Luiz et al modified liposomes with folic acid (FA) and loaded them with curcumin in order to treat breast cancer [ 136 ]. For this purpose, MCF-7 spheroids were obtained using the liquid overlay technique and were used to compare the viability and cellular uptake induced by curcumin alone (CCM), liposomes loaded with curcumin (LIP-CCM) and FA-modified liposomes loaded with curcumin (FA-LIP-CCM).…”

Section: 3d Cultures Studies and Perspectivesmentioning

confidence: 99%

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Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Percivalle

Carofiglio

Conte

et al. 2022

IJMS

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Recent advances in nanomedicine toward cancer treatment have considered exploiting liposomes and extracellular vesicles as effective cargos to deliver therapeutic agents to tumor cells. Meanwhile, solid-state nanoparticles are continuing to attract interest for their great medical potential thanks to their countless properties and possible applications. However, possible drawbacks arising from the use of nanoparticles in nanomedicine, such as the nonspecific uptake of these materials in healthy organs, their aggregation in biological environments and their possible immunogenicity, must be taken into account. Considering these limitations and the intrinsic capability of phospholipidic bilayers to act as a biocompatible shield, their exploitation for effectively encasing solid-state nanoparticles seems a promising strategy to broaden the frontiers of cancer nanomedicine, also providing the possibility to engineer the lipid bilayers to further enhance the therapeutic potential of such nanotools. This work aims to give a comprehensive overview of the latest developments in the use of artificial liposomes and naturally derived extracellular vesicles for the coating of solid-state nanoparticles for cancer treatment, starting from in vitro works until the up-to-date advances and current limitations of these nanopharmaceutics in clinical applications, passing through in vivo and 3D cultures studies.

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Section: 3d Cultures Studies and Perspectivesmentioning

confidence: 92%

Section: 3d Cultures Studies and Perspectivesmentioning

confidence: 99%

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Percivalle

Carofiglio

Conte

et al. 2022

IJMS

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show abstract

“…This study also indicated the high targeting of the folate to cancer cells and was also able to mediate cellular endocytic liposomes. Folate-modified curcumin-loaded liposomes developed by Luiz et al (2022) were also shown to higher cellular internalization and spheroid penetration than the free curcumin and unmodified liposomes using 2D and 3D breast cancer cells model. Folate receptor can be abundantly expressed on various types of cancer cells, and the high targeting of folic acid to cancer cells will help us develop drugs to treat cancer.…”

Section: Vitamin-modified Liposomesmentioning

confidence: 96%

Specific surface modification of liposomes for gut targeting of food bioactive agents

Zhang

Pan

et al. 2023

Comp Rev Food Sci Food Safe

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Liposomes have become a research hotspot in recent years as food delivery systems with attractive properties, including the bilayer structure assembled like the cell membrane, reducing the side‐effect and improving environmental stability of cargos, controlling release, extending duration of functional ingredients, and high biodegradable and biocompatible abilities in the body. However, the conventional liposomes lack stability during storage and are weak in targeted absorption in the gastrointestinal track. At present, surface modification has been approved to be an effective platform to shield these barricades and help liposomes deliver the agents safely and effectively to the ideal site. In this review, the gastrointestinal stability of conventional liposomes, cargo release models from liposomes, and the biological fate of the core materials after release were emphasized. Then, the strategies in both physical and chemical perspectives to improve the stability and utilization of liposomes in the gastrointestinal tract, and the emerging approaches for improving gut targeting by specifically modified liposomes and the intestinal receptors relative to liposomes/cargos absorption were highlighted. Last but not the least, the safety, challenges, and opportunities for the improvement of liposomal bioavailability were also discussed to inspire new applications of liposomes as oral carriers.

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“…Nowadays, active targeting has become the mainstay of cancer therapy, promoting preferential drug accumulation at the tumor sites while sparing healthy tissues, leading to enhanced efficacy and minimizing unwanted toxicities. Therefore, liposomes are often functionalized with various tumor-specific ligands or antibodies, including folic acid [ 32 ], hyaluronic acid [ 33 ], antibodies [ 34 ], and aptamers [ 35 ], to achieve active tumor targeting. Liposomes and other nanocarriers can also be constructed with specific materials to facilitate chemotherapeutics release in response to TME.…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

A Recent Review on Cancer Nanomedicine

Giri

Banerjee

Layek

2023

Cancers

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Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor specificity, dose-related toxicity, low bioavailability, and lack of stability of chemotherapeutics are major hindrances to cancer treatment. Nanomedicine has drawn the attention of many researchers due to its potential for tumor-specific delivery while minimizing unwanted side effects. The application of these nanoparticles is not limited to just therapeutic uses; some of them have shown to have extremely promising diagnostic potential. In this review, we describe and compare various types of nanoparticles and their role in advancing cancer treatment. We further highlight various nanoformulations currently approved for cancer therapy as well as under different phases of clinical trials. Finally, we discuss the prospect of nanomedicine in cancer management.

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Folic acid-modified curcumin-loaded liposomes for breast cancer therapy

Cited by 22 publications

References 68 publications

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Specific surface modification of liposomes for gut targeting of food bioactive agents

A Recent Review on Cancer Nanomedicine

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