Folic acid intestinal absorption in newborn rats at 21 day postpartum: Effects of maternal ethanol consumption

Tavares, Eva; Gómez‐Tubío, Ana; Murillo, María Luisa Ojeda; Carreras, Olimpia

doi:10.1016/s0024-3205(99)00147-2

Cited by 21 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27 In 1993, Balagui et al 28 showed that pancreatic zymogenic granules were fewer per cell and were generally smaller in size in folate-deficient rats. The folic acid decrease produced by the chronic ethanol ingestion, shown previously by our research group, 13 could reduce, at least in part, digestive enzyme activities in the pancreas. However, a folic acid supplement does not exert an advantageous effect on pancreatic enzyme activities.…”

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Gender difference in the pancreatic trypsinogen response to ethanol withdrawal in rat pups

García-benítez¹,

MJ²,

ML³

et al. 2004

Addiction Biology

View full text Add to dashboard Cite

This study was designed to examine the effects of ethanol withdrawal on offspring rats that consumed ethanol during gestation and lactation, in order to examine whether there was an improvement in pancreatic trypsinogen and lipase activities at 2 months postpartum with respect to offspring that fed on ethanol until death. A second purpose for our study was to determine if a folic acid supplement during gestation and lactation was sufficient or insufficient to reverse the negative effects of ethanol consumption. Both genders were used with the aim of investigating any differential pancreatic behaviour. The animals were randomized into five groups: the control group (CG) received water and a basic rat diet during pregnancy, lactation and growth; the ethanol group (EG) was fed an ethanol diet during pregnancy, the suckling period and growth until death; the ethanol-water group's (E+WG) ethanol was eliminated after lactation; The ethanol-folic acid group (E+FG) received a folic acid supplemented diet during pregnancy and the suckling period and in the ethanol+folic acid group (E+FG+FG) this supplementation continued during growth. Our results showed that ethanol administration or ethanol withdrawal did not significantly alter lipase activity in the pancreas. Ethanol administration decreased trypsinogen levels in the pancreas of males and females. However, in males, as opposed to females, the withdrawal of ethanol did not recover the values of pancreatic trypsinogen content, nor did a folic acid supplementation significantly alter the parameters we studied. Our treatment produced no effect on lipase levels. There was a gender-related difference in pancreatic trypsinogen content, the implication being that in future all results on exocrine pancreas function in male and female animals should be analysed separately.

show abstract

Section: Discussionsupporting

confidence: 60%

“…A concentration of 20% v/v was given for 5 additional weeks and maintained during pregnancy and lactation periods, and was administered to offspring during growth for up to 2 months. This schedule, used in previous studies by our group, 12,13 proved not to show adverse effects on reproduction.…”

Section: Animalsmentioning

confidence: 77%

Gender difference in the pancreatic trypsinogen response to ethanol withdrawal in rat pups

García-benítez¹,

MJ²,

ML³

et al. 2004

Addiction Biology

View full text Add to dashboard Cite

show abstract

“…Ethanol may also impair lactation performance, mammary gland function and newborns growth (Ludena et al, 1983). Moreover, chronic alcohol administration to the lactating rats also affects suckling-induced prolactin release (Tavares et al, 1999;Luisa et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Perinatal ethyl alcohol effects on the development of cerebellar cortex in albino rat

Allam¹

2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

The present study aimed to show the effect of chronic low dose of ethyl alcohol on the cerebellar neurons in rat newborns. After birth, the newborns were divided into five groups: A, B, C, D and E. Group A is normal newborns while groups B, C, D and E are treated groups. The present results confirmed that ethanol during pregnancy has adverse effects on the neurogenesis of cerebellar cortex. These effects extended to the postnatal stages. The treated groups showed cell loss represented by neurocyte chromatolysis and pyknosis. Alcohol affects the dendritic tree of Purkinje cells so it was reduced in groups B and C, but was moderate in size in groups D and E. The normal Purkinje cells were deeply stained; this reflects the high amount of Nissl granules if compared with other treated groups. In group B, some of the detected neurons were degenerated. In group C, most of neurons were pale at days 7 and 21, while they were moderately-stained in groups D and E.

show abstract

“…Ethanol abuse frequently leads to the development of vitamin deficiency, with folate deficiency being one of the most common 7,20 . This may explain the occurrence of congenital anomalies in Group HE.…”

Section: Discussionmentioning

confidence: 99%

“…Ethanol abuse is known to lead to folic acid deficiency since it interferes with the transport, absorption and metabolism of this vitamin 7,8 especially during pregnancy, a period during which the need for this molecule increases. The acute use of alcohol also seems to have a negative effect on fetal development and on folic acid.…”

Section: -mentioning

confidence: 99%

Etanol, deficiência de ácido fólico e associação desses dois fatores durante a gestação de camundongos swiss

Gutierrez¹

View full text Add to dashboard Cite

show abstract

Folic acid intestinal absorption in newborn rats at 21 day postpartum: Effects of maternal ethanol consumption

Cited by 21 publications

References 27 publications

Gender difference in the pancreatic trypsinogen response to ethanol withdrawal in rat pups

Gender difference in the pancreatic trypsinogen response to ethanol withdrawal in rat pups

Perinatal ethyl alcohol effects on the development of cerebellar cortex in albino rat

Etanol, deficiência de ácido fólico e associação desses dois fatores durante a gestação de camundongos swiss

Contact Info

Product

Resources

About