Folic acid in low birthweight infants

Kendall, Alexandra C.; Jones, E. Elizabeth; Wilson, C. I. D.; Shinton, N. K.; Elwood, Peter Creighton

doi:10.1136/adc.49.9.736

Cited by 20 publications

(11 citation statements)

References 8 publications

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“…The administration of 50 ,g folic acid per day to low birthweight infants did not increase their weight at 6 months (Kendall et al, 1974). More recently, Gandy and Jacobson (1977a) found in infants with erythroblastosis fetalis a tendency to low serum-folate, which persisted throughout the first year of life.…”

Section: Discussionmentioning

confidence: 89%

Folate nutrition and growth in infancy.

Matoth¹,

Zehavi²,

Topper³

et al. 1979

Archives of Disease in Childhood

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SUMMARY The effect of suboptimal folate nutrition on the growing infant was studied in a population of infants fed a diet based on boiled, pasteurised cows' milk. One group of infants received a daily supplement of 1 mg folic acid from age 2 months, while the other group received a placebo. The infants were seen at bimonthly intervals. In the supplemented group the red cell folate level had increased to twice its pretreatment value by 4 months, and remained at this high level to the end of the first year. Hb concentration and incidence of anaemia were similar in both groups. The incidence of infection in the two groups did not differ. Weights and lengths attained at 6 months, and the rate of gain from 2 to 6 months were higher in infants whose folate levels were above the median value than in those below it. In the second half of the first year the differences between the two groups were no longer evident.

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Section: Discussionmentioning

confidence: 89%

Folate nutrition and growth in infancy.

Matoth¹,

Zehavi²,

Topper³

et al. 1979

Archives of Disease in Childhood

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“…Roberts et al (16) reported higher levels of red cell folate as well as hemoglobin in patients receiving folic acid supplementation, whereas Kendall et al (17) observed no discernible difference between infants receiving folic acid supplementation and those taking placebo. Maternal smoking seems to be another important factor influencing the folate levels in newborns.…”

Section: Discussionmentioning

confidence: 99%

Is Folic Acid Supplementation Really Necessary in Preterm Infants ≤32 Weeks of Gestation?

Öncel

Çalışıcı

Оздемир

et al. 2014

J. pediatr. gastroenterol. nutr.

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“…The clinical results of folic acid supple mentation in LBW infants are somewhat controversial since a clear hematological re sponse has not always been seen [54][55][56][57][58], However, it has been shown that a test dose of folic acid given to newborn infants disap pears from the blood more rapidly than in older subjects without any increase in the amount excreted in the urine [47], This has been interpreted as evidence of an increased requirement of this vitamin.…”

Section: Prematurity' and Other Special Clinical Conditionsmentioning

confidence: 99%

Vitamins and the Premature

Orzalesi

1987

Neonatology

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Vitamins are organic compounds essential in small amounts for metabolic functions. Since they cannot be synthesized in the body they must be supplied with the diet. While fat-soluble vitamins cross the placenta by single and/or facilitated diffusion the water-soluble vitamins are actively transported with the exception of vitamin C. An adequate supply of fat-soluble vitamins to the fetus seems to be dependent on maternal blood levels during gestation. On the contrary, the transfer of water-soluble vitamins is relatively independent of the levels in maternal blood. Due to their immaturity preterm and low birth weight infants require higher dosages of some vitamins compared to healthy full-term newborns.

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Folic acid in low birthweight infants

Cited by 20 publications

References 8 publications

Folate nutrition and growth in infancy.

Folate nutrition and growth in infancy.

Is Folic Acid Supplementation Really Necessary in Preterm Infants ≤32 Weeks of Gestation?

Vitamins and the Premature

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