Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

Dong, Hong; Yang, Guixin; Zhang, Xin; Meng, Xiangtai; Sheng, Jing‐Li; Sun, Xiaojun; Feng, Yujie; Zhang, Fengming

doi:10.1002/chem.201804153

Cited by 88 publications

(48 citation statements)

References 44 publications

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“…There into, metal‐organic frameworks (MOFs) as heterogeneous ODS catalysts have been attempted in this field due to their advantages such as diverse pore size, large surface area and rich metal sites . However, as known, generally metal sites in MOFs with high crystallinity are well coordinated with organic linkers and they are inactive in catalytic reactions . Additionally, the chemical and thermal stability of many MOFs is poor.…”

Section: Introductionmentioning

confidence: 99%

Creation of Active Sites in MOF‐808(Zr) by a Facile Route for Oxidative Desulfurization of Model Diesel Oil

et al. 2020

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MOF‐808(Zr) as an important member of metal‐organic frameworks (MOFs) has attracted much attention due to its good stability, large surface area and rich zirconium metal centers. However, Zr sites in the structure of MOF‐808(Zr) are inactive in many catalytic reactions due to they are well coordinated with organic ligands like 1,3,5‐benzenetricarboxylic acid (BTC) and formate anions. Thus, removing formate anions have been attempted to create more active sites in the structure for many reactions while maintaining the structural stability. In this work, we report that the formate ligands in MOF‐808(Zr) can be facilely removed by the treatment in hot ethanol for 4 h. The obtained material as a heterogeneous catalyst exhibited superior catalytic activity in the oxidative desulfurization (ODS) reaction of dibenzothiophene (DBT) compared with reported MOFs catalysts. The conversion of DBT in model diesel oil could reach >99 % within a reaction time of 20 min at 323 K, which is five times as that over parent MOF‐808(Zr). As a result, the sulfur content was decreased from 1000 ppm to less than 10 ppm. Such catalytic performance should be mainly attributed to the creation of more active sites in the structure of MOF‐808(Zr) after the removal of formate anions.

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Section: Introductionmentioning

confidence: 99%

Creation of Active Sites in MOF‐808(Zr) by a Facile Route for Oxidative Desulfurization of Model Diesel Oil

et al. 2020

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“…Folic acid was successfully added to zirconium-based MOFs, MOF-808 and Nh2- Uio-66 followed by encapsulation of 5-FU. The NMOFs loaded with 5-FU exhibited pH-sensitive drug release, enhanced cellular uptake and cytotoxicity against HeLa cells [ 99 ].…”

Section: Folic Acid—targeted Nanoparticlesmentioning

confidence: 99%

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

et al. 2021

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Cancer is one of the major causes of death worldwide and its treatment remains very challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific delivery of the drug. Nanoparticle drug delivery systems have been developed to avoid the side effects of the conventional chemotherapy. However, according to the most recent recommendations, future nanomedicine should be focused mainly on active targeting of nanocarriers based on ligand-receptor recognition, which may show better efficacy than passive targeting in human cancer therapy. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumour microenvironment. Thus, the NPs are improved toward an additional functionality, e.g., pH-sensitivity (advanced single-targeted NPs). Moreover, dual-targeted nanoparticles which contain two different types of targeting agents on the same drug delivery system are developed. The advanced single-targeted NPs and dual-targeted nanocarriers present superior properties related to cell selectivity, cellular uptake and cytotoxicity toward cancer cells than conventional drug, non-targeted systems and single-targeted systems without additional functionality. Folic acid and biotin are used as targeting ligands for cancer chemotherapy, since they are available, inexpensive, nontoxic, nonimmunogenic and easy to modify. These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach. This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.

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“…Shi et al also prepared a pH responsive and folic acid induced dual targeting formulation FA-PEG/CQ@ZIF-8 [13]. The same strategy was also included in Dong's report [33]. The folic acid was modified on a pH-sensitive metal organic framework to obtain FA/5-FU@MOF-808 and FA/5-FU@NH 2 -UiO-66.…”

Section: Multi-targeted Response Of Mof Nanomaterials For Anticancer Tmentioning

confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

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Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

Cited by 88 publications

References 44 publications

Creation of Active Sites in MOF‐808(Zr) by a Facile Route for Oxidative Desulfurization of Model Diesel Oil

Creation of Active Sites in MOF‐808(Zr) by a Facile Route for Oxidative Desulfurization of Model Diesel Oil

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

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