Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging

Qiao, Juan; Mu, Xiaoyu; Li, Qi; Deng, Jingjing; Mao, Lanqun

doi:10.1039/c3cc44256j

Cited by 121 publications

(85 citation statements)

References 14 publications

(12 reference statements)

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“…1,3 Due to their ultra small size, excellent luminescence properties, and stable structures, Au NCs have attracted significant attention in the past decade. [2][3][4][5] Chen et al 6 determined the enzyme activity by assessing the change in emission intensity of fluorescent Au NCs, Qiao et al 7 reported that ovalbumin-protected Au NCs with folic acid can be used for HeLa cells imaging, and Yue et al 8 synthesized bovine serum albumin-capped Au NCs as a fluorescence probe to determine nitrite (NO 2 -) sensitively and selectively. Inorganic nanoparticles are difficult to biodegrade and induce long-term toxicity, which hinders their application in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of gold nanoclusters in human liver cancer cells

Yang¹,

Jing²,

Hou³

et al. 2014

IJN

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In this study, we synthesized water-soluble fluorescent gold nanoclusters (Au NCs) stabilized with dihydrolipoic acid (DHLA). The cytotoxicity of these Au NCs was then assessed in the normal human hepatic cell line (L02) and the human hepatoma cell line (HepG2) at different exposure times. Cell viability was normal in both cell lines at 24 hours and 48 hours; however, the growth of HepG2 cells was significantly inhibited at 72 hours. The change in lactate dehydrogenase level was strongly correlated with cell viability after 72 hours incubation with DHLA–capped Au NCs, and the increase in cellular reactive oxygen species may be related to the decrease in cell viability. Growth inhibition of HepG2 cells was possibly due to difficultly passing the checkpoint between G1 phase and S phase. The anticancer activity of DHLA–capped Au NCs should be considered when used in biomedical imaging and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity of gold nanoclusters in human liver cancer cells

Yang¹,

Jing²,

Hou³

et al. 2014

IJN

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“…Labeling of biomolecules is the key basis of AuNCs for their further biomedical applications [65,66]. Such bioconjugations commonly depend on adsorption, chelation, and covalent interaction.…”

Section: Functionalization Of Auncsmentioning

confidence: 99%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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“…In addition, a competition experiment was carried out by adding a certain amount of free FA before FA-TiO 2 and TiO 2 treatment [25].…”

Section: Targeting Ability Of Fa-tiomentioning

confidence: 99%

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

Gao

Han

Wang

et al. 2015

Materials Science in Semiconductor Processing

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Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging

Cited by 121 publications

References 14 publications

Cytotoxicity of gold nanoclusters in human liver cancer cells

Cytotoxicity of gold nanoclusters in human liver cancer cells

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

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Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging

Cited by 121 publications

References 14 publications

Cytotoxicity of gold nanoclusters in human liver&nbsp;cancer cells

Cytotoxicity of gold nanoclusters in human liver&nbsp;cancer cells

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

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Cytotoxicity of gold nanoclusters in human liver cancer cells

Cytotoxicity of gold nanoclusters in human liver cancer cells