Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)

Song, Yinxue; Zhou, Bin; Du, Xiaoxu; Wang, Yong; Zhang, Jie; Ai, Yanqiu; Xia, Zhen; Zhao, Guimin

doi:10.1016/j.biopha.2019.109561

Cited by 93 publications

(39 citation statements)

References 52 publications

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“…Furthermore, the nanocarriers have the potential to improve the pharmacokinetics and biodistribution of siRNA significantly and can be chemically modified to anchor another bioactive molecule into its structure to implement its therapeutic action for which the siRNA has been designed. For example, mesoporous silica nanoparticles that incorporate folic acid promoting endocytosis [ 10 ] or amphiphilic dendrimer with RGDK peptide sequences [ 11 ] have been described as efficient vectors for transfection of various siRNAs. Dendrimers are monodisperse materials that have interesting properties that can be used in different biomedical fields and have proved useful transfecting agent [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

et al. 2020

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Cancer treatment with small interfering RNA (siRNA) is one of the most promising new strategies; however, transfection systems that increase its bioavailability and ensure its delivery to the target cell are necessary. Transfection systems may be just vehicular or could contain fragments with anticancer activity that achieves a synergistic effect with siRNA. Cationic carbosilane dendrimers have proved to be powerful tools as non-viral vectors for siRNA in cancer treatment, and their activity might be potentiated by the inclusion of metallic complexes in its dendritic structure. We have herein explored the interaction between Schiff-base carbosilane copper (II) metallodendrimers, and pro-apoptotic siRNAs. The nanocomplexes formed by metallodendrimers and different siRNA have been examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes has been estimated by flow cytometry and confocal microscopy in a human breast cancer cell line (MCF-7), following the ability of these metallodendrimers to deliver the siRNA into the cell. Finally, in vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells. Combination of the first-generation derivatives with chloride counterions and with siRNA increases the anticancer activity of the dendriplex constructs and makes them a promising non-viral vector.

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Section: Introductionmentioning

confidence: 99%

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

et al. 2020

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“…In addition, this approach also decreased the doses of PTX, thereby, reducing the side effects associated with PTX alone [ 19 ]. A similar study was conducted by Song et al in 2020, which also encapsulated myricetin and siRNA in mesoporous silica nanoparticles and showed its synergistic effect to suppress tumor growth in lung cancer cells with lesser side effects [ 20 ].…”

Section: Evidences On Drug Delivery Approaches Of Mirna In Respiratormentioning

confidence: 87%

miRNA Nanotherapeutics: Potential and Challenges in Respiratory Disorders

et al. 2020

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“…Dilnawaz and Sahoo ( 2018 ) demonstrated that the combination of the chemotherapeutic drug (etoposide or docetaxel) or the proteasome inhibitor carfilzomib with survivin siRNA could induce a 12.4 or 14.6% increase in apoptosis, respectively, in A549 cells. Considering that the overexpression of multidrug resistance protein 1 (MRP1) is significantly related to the clinical drug resistance of many kinds of tumors, Song et al ( 2020 ) loaded MRP-1 siRNA and myricetin into MSNs and modified the nanoparticles with folic acid to target lung cancer cells. In vitro experiments showed that Myr-MRP-1/MSN-FA can significantly inhibit the proliferation of cancer cells and in vivo experiments further verified this therapeutic effect, in which the tumor volume of mice treated with Myr-MRP-1/MSN-FA decreased the most.…”

Section: Chemotherapy and Gene Therapymentioning

confidence: 99%

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

Gao

Shen

et al. 2020

Front. Chem.

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Chemotherapy is an important anti-tumor treatment in clinic to date, however, the effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic toxicity, and multidrug resistance. In recent years, mesoporous silica nanoparticles (MSNs) have become exciting drug delivery systems (DDS) due to their unique advantages, such as easy large-scale production, adjustable uniform pore size, large surface area and pore volumes. While mesoporous silica-based DDS can improve chemotherapy to a certain extent, when used in combination with other cancer therapies MSN based chemotherapy exhibits a synergistic effect, greatly improving therapeutic outcomes. In this review, we discuss the applications of MSN DDS for a diverse range of chemotherapeutic combination anti-tumor therapies, including phototherapy, gene therapy, immunotherapy and other less common modalities. Furthermore, we focus on the characteristics of each nanomaterial and the synergistic advantages of the combination therapies. Lastly, we examine the challenges and future prospects of MSN based chemotherapeutic combination therapies.

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Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)

Cited by 93 publications

References 52 publications

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

miRNA Nanotherapeutics: Potential and Challenges in Respiratory Disorders

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

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