Folic acid enhances lithium prophylaxis

Coppen, Alec; Chaudhry, Shafqat Rasul; Swade, Cynthia

doi:10.1016/0165-0327(86)90043-1

Cited by 135 publications

(72 citation statements)

References 8 publications

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“…Studies in older age groups also show that folate and B6 status are lower in depressed populations (Gilbody et al, 2007;Merete et al, 2008). Further to this, vitamin B6 supplementation has been associated with improvement of depressive symptoms (Wyatt et al, 1999) and randomised controlled trials have successfully used folic acid to improve the efficacy of antidepressant medications (Coppen and Bailey, 2000;Coppen et al, 1986;Godfrey et al, 1990). In contrast, a study of adolescents in the US showed no association between B6, B12 and folate intake with depressive symptoms (Fulkerson et al, 2004), although the findings were restricted to univariate analyses of vitamin intake without adjustment for confounding factors.…”

Section: Discussionmentioning

confidence: 97%

Low intake of B-vitamins is associated with poor adolescent mental health and behaviour

Herbison

Hickling

Allen

et al. 2012

Preventive Medicine

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Section: Discussionmentioning

confidence: 97%

Low intake of B-vitamins is associated with poor adolescent mental health and behaviour

Herbison

Hickling

Allen

et al. 2012

Preventive Medicine

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“…They suggested that folate levels be considered in the evaluation of depressed patients who do not respond to antidepressant treatment. Although both folate (126) and methylfolate (118) have been reported to have antidepressant activity, it is unclear whether folate administration has any clinical effect in patients who are not deficient in this vitamin because there do not seem to be any studies in this population.…”

Section: Vitamin B 12 and Folatementioning

confidence: 95%

Diagnostic and Statistical Manual of Mental Disorders

2018

The SAGE Encyclopedia of Intellectual and Developmental Disorders

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Alternative therapies are widely used by consumers. A number of herbs and dietary supplements have demonstrable effects on mood, memory, and insomnia. There is a significant amount of evidence supporting the use of Hypericum perforatum (St. John's wort) for depression and Ginkgo biloba for dementia. Results of randomized, controlled trials also support the use of kava for anxiety and valerian for insomnia. Although evidence for the use of vitamins and amino acids as sole agents for psychiatric symptoms is not strong, there is intriguing preliminary evidence for the use of folate, tryptophan, and phenylalanine as adjuncts to enhance the effectiveness of conventional antidepressants. S-adenosylmethionine seems to have antidepressant effects, and omega-3 polyunsaturated fatty acids, particularly docosahexaenoic acid, may have mood-stabilizing effects. More research should be conducted on these and other natural products for the prevention and treatment of various psychiatric disorders.

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“…There is also evidence to suggest that folate supplementation may have a beneficial impact on mood when used during the long-term treatment of MDD. A study by Coppen et al [35], for instance, involving 70 depressed outpatients treated with lithium and double-blind folate or placebo for 6 months, revealed a significantly greater reduction in depression severity at endpoint in patients with MDD (n=53, P<0.05), but not bipolar patients (n=17, P>0.05) treated with lithium and adjunctive folate compared with patients with MDD treated with adjunctive placebo.…”

Section: The Relevance Of S-adenosyl-methionine and Other Elements Ofmentioning

confidence: 95%

S-adenosyl-methionine in depression: A comprehensive review of the literature

Papakostas

Alpert²,

Fava³

2003

Curr Psychiatry Rep

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As many as 29% to 46% of patients with major depressive disorder (MDD) show only partial or no response to an adequate course of an antidepressant. The current practice is to increase the dose, switch to another antidepressant, or to combine the initial antidepressant with an antidepressant of a different class or a non-antidepressant agent. A growing number of studies have also been directed toward exploring the potential use of augmenting traditional antidepressants with nonpharmaceutic supplements, or even using such supplements as monotherapy for depression. S-adenosyl-methionine (SAMe) is one such compound. Compared with many other nonpharmaceutic supplements, SAMe has been extensively studied, and impressive literature extending back three decades suggests the antidepressant efficacy of SAMe. In the present work, the authors summarize the literature, focusing on the potential role of SAMe and its precursors in the pathophysiology of MDD, followed by a review of studies examining the use of SAMe for the treatment of MDD. Finally, the authors propose a model that would explain the actions of SAMe in the central nervous system.

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Folic acid enhances lithium prophylaxis

Cited by 135 publications

References 8 publications

Low intake of B-vitamins is associated with poor adolescent mental health and behaviour

Low intake of B-vitamins is associated with poor adolescent mental health and behaviour

Diagnostic and Statistical Manual of Mental Disorders

S-adenosyl-methionine in depression: A comprehensive review of the literature

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