Folic acid

Davis, Richard E.; Nicol, D.J.

doi:10.1016/0020-711x(88)90476-4

Cited by 28 publications

(9 citation statements)

References 54 publications

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“…Figure 1 shows the structures and interconversions of bioactive reduced folate derivatives. Whereas 5-methyltetrahydrofolate (5-CH 3 -H 4 PteGlu) is the principal folate in plasma (8,38), we found four reduced folate derivatives in rat bile, tetrahydrofolate (H 4 PteGlu), 5-CH 3 -H 4 PteGlu, 5,10-methylenetetrahydrofolate (5,10-CH 2 -H 4 PteGlu), and 10-formyltetrahydrofolate (10-HCO-H 4 PteGlu), as shown in Fig. 1 (29,30,31).…”

mentioning

confidence: 55%

“…enterohepatic circulation; organic anion; active transport; Eisai hyperbilirubinemic rats REDUCED FOLATE IS REQUIRED to provide single-carbon units for the synthesis of purines and thymidine, for the interconversion of serine and glycine, for the degradation of histidine and glycine, and for the methylation of homocysteine to regenerate methionine ( Fig. 1) (2,3,8,28,34). Figure 1 shows the structures and interconversions of bioactive reduced folate derivatives.…”

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confidence: 99%

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Reduced folate derivatives are endogenous substrates for cMOAT in rats

Kusuhara

Han

Shimoda

et al. 1998

American Journal of Physiology-Gastrointestinal and Liver Physi

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We examined the role of the canalicular multispecific organic anion transporter (cMOAT) in the biliary excretion of reduced folate derivatives in vivo and in vitro using normal [Sprague-Dawley rats (SDR)] and mutant [Eisai hyperbilirubinemic rats (EHBR)] rats whose cMOAT is hereditarily deficient. In vivo, the biliary excretion of endogenous tetrahydrofolate (H4PteGlu), 5-methyltetrahydrofolate (5-CH3-H4PteGlu), and 5,10-methylenetetrahydrofolate (5,10-CH2-H4PteGlu) in EHBR was reduced to 8.2%, 1.9%, and 5.5% of those in SDR, respectively, whereas that of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) was detected only in SDR and not in EHBR. Bile drainage caused reduction of endogenous plasma folate concentrations in SDR but not in EHBR. In vitro, significant ATP-dependent uptake of3H-labeled 5-CH3-H4PteGlu into canalicular membrane vesicles was observed only in SDR. This ATP-dependent uptake was saturable with a Michaelis constant ( K m) value of 126 μM, which was comparable with its inhibitor constant ( K i) value of 121 μM for the ATP-dependent uptake of a typical cMOAT substrate, 2,4-dinitrophenyl- S-glutathione (DNP-SG). Vice versa, DNP-SG inhibited the uptake of 5-CH3-H4PteGlu with a K i of 35 μM, which was similar to its K m value. In addition, H4PteGlu and 5,10-CH2-H4PteGlu also inhibited the ATP-dependent uptake of DNP-SG. These results indicate that 5-CH3-H4PteGlu and other derivatives are transported via cMOAT. Therefore, reduced folate derivatives are the first endogenous substrates for cMOAT that do not contain glutathione, glucuronide, or sulfate moieties.

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confidence: 55%

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confidence: 99%

Reduced folate derivatives are endogenous substrates for cMOAT in rats

Kusuhara

Han

Shimoda

et al. 1998

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Its concentration is higher (~5×) in colostrum than in milk (Nygren-Babol et al 2004). FBP is crucial for the assimilation, distribution and retention of folic acid (Davis and Nichol 1988) and is antibacterial through reducing the availability of folate to microorganisms. The effectiveness of FBP is reduced by heat treatment of milk (Gregory 1982;Achanta et al 2007).…”

Section: Folate-binding Proteinmentioning

confidence: 99%

Dairy Chemistry and Biochemistry

Fox¹,

Uniacke‐Lowe²,

McSweeney³

et al. 2015

568

570

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“…Folic acid (pteroylmono-glutamic acid) plays an important role in the biosynthesis of amino acids, purines and thymidylates by acting as a C1-group donor [ 93 ]. Mammals are unable to synthesize folate and therefore rely on their diet to keep their folate levels constant [ 94 ].…”

Section: Targets For Cancer Stratification By Molecular Imagingmentioning

confidence: 99%

Cancer Stratification by Molecular Imaging

Weber

Haberkorn

Mier

2015

IJMS

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The lack of specificity of traditional cytotoxic drugs has triggered the development of anticancer agents that selectively address specific molecular targets. An intrinsic property of these specialized drugs is their limited applicability for specific patient subgroups. Consequently, the generation of information about tumor characteristics is the key to exploit the potential of these drugs. Currently, cancer stratification relies on three approaches: Gene expression analysis and cancer proteomics, immunohistochemistry and molecular imaging. In order to enable the precise localization of functionally expressed targets, molecular imaging combines highly selective biomarkers and intense signal sources. Thus, cancer stratification and localization are performed simultaneously. Many cancer types are characterized by altered receptor expression, such as somatostatin receptors, folate receptors or Her2 (human epidermal growth factor receptor 2). Similar correlations are also known for a multitude of transporters, such as glucose transporters, amino acid transporters or hNIS (human sodium iodide symporter), as well as cell specific proteins, such as the prostate specific membrane antigen, integrins, and CD20. This review provides a comprehensive description of the methods, targets and agents used in molecular imaging, to outline their application for cancer stratification. Emphasis is placed on radiotracers which are used to identify altered expression patterns of cancer associated markers.

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Folic acid

Cited by 28 publications

References 54 publications

Reduced folate derivatives are endogenous substrates for cMOAT in rats

Reduced folate derivatives are endogenous substrates for cMOAT in rats

Dairy Chemistry and Biochemistry

Cancer Stratification by Molecular Imaging

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