Folic-Acid Deficiency in Chronic Arsenic Poisoning

Tongeren, J. H. M. Van; Kunst, A.; Majoor, C.L.H.; Schillings, P.H.M.

doi:10.1016/s0140-6736(65)92956-9

Cited by 20 publications

(11 citation statements)

References 8 publications

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“…Hematological abnormalities are also encountered with prolonged exposure to arsenic and are typically characterized by cytopenias including leukopenia, anemia, and thrombocytopenia in order of decreasing frequency [ 3,4]. In addition, rare reports in the literature have described megaloblastic maturation and dyserythropoietic changes [3][4][5][6]; thus, prolonged exposure to arsenic may result in a hematological picture resembling megaloblastic anemia and the myelodysplastic syndromes. The following case report describes a patient who, at presentation, appeared to have a myelodysplastic syndrome, but on subsequent laboratory investigation was determined to have been exposed to arsenic.…”

Section: Introductionmentioning

confidence: 99%

Arsenic intoxication presenting as a myelodysplastic syndrome: A case report

et al. 1991

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A case of arsenic intoxication presenting as a myelodysplastic syndrome is reported. A 41-year-old woman with a 6-month history of gastrointestinal and neurological symptoms was noted to be pancytopenic at presentation. A bone marrow aspirate revealed dysmyelopoietic changes involving all three marrow cell lines. Subsequent analysis of urine for heavy metals demonstrated very high levels of arsenic. Treatment with British anti-Lewisite (BAL) resulted in the resolution of gastrointestinal symptoms and hematological abnormalities although the neurological complications progressed. This case emphasizes that heavy metal intoxication should be considered in the differential diagnosis of any individual presenting with the hematological features of myelodysplasia especially when accompanied by clinical features considered atypical for primary or secondary myelodysplasia.

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Section: Introductionmentioning

confidence: 99%

Arsenic intoxication presenting as a myelodysplastic syndrome: A case report

et al. 1991

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“…In ad dition, a case of chronic arsenic poisoning with megalo blastic anemia has been described, but the patient also had low scrum folate levels [9]. The authors suggest that mega loblastic anemia in this patient was due to the folic acid de ficiency, and that arsenic inhibited the enzymatic conver sion of folic acid into its biologically active derivatives [8].…”

Section: Discussionmentioning

confidence: 94%

Arsenic Intoxication Presenting with Macrocytosis and Peripheral Neuropathy, without Anemia

Heaven¹,

Duncan

Vukelja³

1994

Acta Haematol

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A case of arsenic intoxication associated with macrocytosis and neuropathy, without anemia, is presented. Evaluation of a 68-year-old man with a long history of peripheral neuropathy and persistent macrocytosis revealed exposure to an insecticide. Analysis of urine and hair revealed elevated levels of arsenic. A short course of d-penicillamine failed to promote urinary excretion of arsenic. Removal of the insecticide resulted in resolution of macrocytosis and slight improvement of neuropathy. This case emphasizes that arsenic intoxication should be considered in patients with macrocytosis with peripheral neuropathy, even in the absence of anemia.

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“…The patient also rapidly became white-haired following the acute intoxication. Cases of perniciosiform anaemia have been described in connection with chronic arsenic poisoning (3,6). On the last examination performed, patient No.…”

Section: Discussionmentioning

confidence: 99%

Iii Clinical Picture and Treatment in Arsine Poisoning

Anthonisen

Nielsen

Pedersen

et al. 1968

Journal of Internal Medicine

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The 14 patients who were poisoned, and who all survived, were men aged 30-61 years. As it would be exceedingly repetitious to review all the case histories, only three of them will be reported. These represent a mild, a very severe, and a moderately severe case of poisoning, respectively. Putient No. 2. (J. No. KH, 2. dept., 472165). A 61-year-old man, previously healthy, was admitted on 26. 111. 1965 at 11.30 a. m. after having had nausea and diarrhoea over the

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Folic-Acid Deficiency in Chronic Arsenic Poisoning

Cited by 20 publications

References 8 publications

Arsenic intoxication presenting as a myelodysplastic syndrome: A case report

Arsenic intoxication presenting as a myelodysplastic syndrome: A case report

Arsenic Intoxication Presenting with Macrocytosis and Peripheral Neuropathy, without Anemia

Iii Clinical Picture and Treatment in Arsine Poisoning

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