Folic acid-conjugated nanostructured materials designed for cancer cell targetingElectronic supplementary information (ESI) available: experimental details; selected plots and spectra. See http://www.rsc.org/suppdata/cc/b3/b307878g/

Pan, Dipanjan; Turner, Jeffrey L.; Wooley, Karen L.

doi:10.1039/b307878g

Cited by 176 publications

(121 citation statements)

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“…26 The synthesis of folate-PEG-amine followed previously reported methods. [23][24][25] The conjugates showed UV absorptions at 363 nm, representative of folate. The extinction coefficient for folate in pH 7.4 PBS buffer at that wavelength is 6197 M À1 cm À1 .…”

Section: Resultsmentioning

confidence: 99%

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Folate‐mediated cell uptake of shell‐crosslinked spheres and cylinders

Zhang

Rossin

Hagooly

et al. 2008

J. Polym. Sci. A Polym. Chem.

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Section: Resultsmentioning

confidence: 99%

“…[23][24][25] Conjugation to the nanostructures was achieved by use of amidation chemistry. SCK solutions prefunctionalized with fluorescein-5-thiosemicarbazide were each placed into a 25-mL round-bottom flask.…”

Section: Conjugation Of Folate-peg (15 Kda)-amine To Nanostructuresmentioning

confidence: 99%

Folate‐mediated cell uptake of shell‐crosslinked spheres and cylinders

Zhang

Rossin

Hagooly

et al. 2008

J. Polym. Sci. A Polym. Chem.

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“…Using prostate cancer as a model, Farokhzad et al demonstrate the potential utility of polymer micelle-aptamer bioconjugates that encapsulate docetaxel for therapeutic applications [37]. To improve the structure integrity of polymer micelles, the hydrophilic corona has been selectively cross-linked, leading to static entities that are not easily disrupted [38]. Intelligent core-shell nanoparticles have also been produced: thermoresponsive, pH-responsive and biodegradable nanoparticles were made from poly(D,Llactide)-graft-poly(N-isopropyl acrylamide-co-methacrylic acid) (PLA-g-P(NIPAm-co-MAA)) to yield a hydrophilic outer shell and a hydrophobic inner core that exhibited a phase transition temperature above 37°C, rendering them apposite for biomedical applications [39].…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

943

554

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Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering.

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“…1. Alternatives to conventional linear polymers evolved rapidly in the 1980s and 90s, as described by a number of research groups, such as Fre´chet and Tomalia for dendritic polymers, [5][6][7][8][9] Eisenberg, Wooley, Bates, Discher and others for polymer micelles, [10][11][12][13][14][15][16][17][18][19][20][21] and Torchilin for polymer modified liposomes. [22][23][24][25][26] In conjunction with advances in polymer synthesis came novel synthetic strategies for the conjugation, encapsulation, release, and imaging 27 of drugs.…”

Section: Introductionmentioning

confidence: 99%