Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Geszke, Malgorzata; Murias, Marek; Balan, Lavinia; Medjahdi, Ghouti; Korczyński, Jarosław; Moritz, Michał; Lulek, Janina; Schneider, Raphaël

doi:10.1016/j.actbio.2010.10.012

Cited by 178 publications

(139 citation statements)

References 66 publications

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“…These values for ZnS are as follows: Inserting the data in equation 2, we can obtain the particle radius equal to 2.3 nm. The diameter of the particles is 4.6 nm which is in good agreement with the XRD result, unlike in some other reports that imply the difference between XRD and UV sizes for very small particles [17].…”

Section: Resultssupporting

confidence: 79%

“…1b. Size of the particles can also be calculated from Brus equation [17] according to the UV-Vis spectrum of the sample S (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…The onset of the absorption peak is located at 312 nm which shows a reliable blue shift with respect to the bulk ZnS (340 nm). The Brus equation can be written as [17]:…”

Section: Resultsmentioning

confidence: 99%

“…Addition of manganese to ZnS as a doping element leads to a red shift in the emission peak of the PL spectrum [20,21]. On the other hand, reduction of the ZnS particle size leads to the blue shift of the PL emission peak with respect to the bulk ZnS [17]. In many studies, an enhancement in the luminescence intensity has been * E-mail: re.ahmadi@ENG.ikiu.ac.ir reported with the reaction time [22].…”

Section: Introductionmentioning

confidence: 96%

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Kinetics of oxygen adsorption on ZnS nanoparticles synthesized by precipitation process

Ahmadi

Sadrnezhad

Zangeneh

et al. 2016

Materials Science-Poland

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ZnS nanoparticles were synthesized through a one-step precipitation process. Effect of time and temperature on the formation reaction was investigated. The synthesized samples were characterized by X-ray diffraction (XRD), ultraviolet (UV) visible absorption and photoluminescence (PL) spectrophotometry. Based on XRD and UV-Vis data, the particles produced at 70°C had a mean particle size of about 5 nm. Increasing time and temperature of the synthesis reaction resulted in photoluminescence intensification. PL spectroscopy helped understanding the adsorption kinetics of oxygen on ZnS nanoparticles during the precipitation synthesis process. Fabrication of ZnS structures with appropriate oxygen adsorption capacity was suggested as a means of PL emission intensity control.

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Section: Resultssupporting

confidence: 79%

“…1b. Size of the particles can also be calculated from Brus equation [17] according to the UV-Vis spectrum of the sample S (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…The onset of the absorption peak is located at 312 nm which shows a reliable blue shift with respect to the bulk ZnS (340 nm). The Brus equation can be written as [17]:…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Kinetics of oxygen adsorption on ZnS nanoparticles synthesized by precipitation process

Ahmadi

Sadrnezhad

Zangeneh

et al. 2016

Materials Science-Poland

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“…FA, or vitamin B9, is indeed known to be recognized more specifically by cells that over express folate receptors, FR, as in the case of some ovary or breast cancers for instance [44,45]. The capacity for such FA-functionalized nanoparticles to be internalized by cells, most probably via endocytosis, was then followed on both T-47-D (over expressing folate receptors [46], or "FR + ") and ZR-75-1 (without over expression [47], or "FR -") breast cancer cells. The extent of cell uptake was determined by measure by 5 -Nanoparticles concentration range studied: 0 -120 µg/ml 6 -Control experiment carried out in the absence of nanoparticles It may be mentioned here that Methotrexate (MTX), a chemotherapeutic drug, is an anti-folate compound with a chemical formula extremely close to that of folic acid.…”

Section: Cell Uptake and Targeting Aspectsmentioning

confidence: 99%

Biomimetic Apatite-Based Functional Nanoparticles as Promising Newcomers in Nanomedicine: Overview of 10 Years of Initiatory Research

Drouet¹

2015

IMPH

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Biomimetic calcium phosphate apatites, analogous to bone mineral, may now be produced synthetically. Their intrinsic biocompatibility and the nanometer dimensions of their constitutive crystals not only allow one to envision applications in bone tissue regeneration, but also in other medical fields such as nanomedicine, and in particular in view of cell diagnosis.In this mini-review, we look back at 10 years of our dedicated research, and summarize the main advances made in terms of preparation, physical-chemical characterizations and biological evaluations of colloidal formulations of biomimetic apatite-based nanoparticles, which we illustrate here with the angle of cancer diagnosis. The confirmed exceptional biocompatibility of these engineered nanoparticles, associated to the possibility to confer them luminescence properties by way of controlled lanthanide doping, and their capacity to be internalized by cells, including with cancer cell addressing abilities (shown here as a proof of concept), underline that biomimetic apatite-based colloidal nanoparticles are particularly promising for nanomedicine applications, for example related to diseased cells diagnosis. Multidisciplinary research on these functional nanoparticles, initiated as described here, has now generated emulation in the scientific community where the concept of apatite nanoparticles for nanomedicine is being, gratifyingly, appropriated.

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An Acceptor–Donor–Acceptor Structured Small Molecule for Effective NIR Triggered Dual Phototherapy of Cancer

Zhao

Zhang

et al. 2020

Adv Funct Materials

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Dual phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is regarded as a more effective method for cancer treatment than single PDT or PTT. However, development of single component and near-infrared (NIR) triggered agents for efficient dual phototherapy remains a challenge. Herein, a simple strategy to develop dual-functional small-molecules-based photosensitizers for combined PDT and PTT treatment is proposed through: 1) finely modulating HOMO-LUMO energy levels to regulate the intersystem crossing (ISC) process for effective singlet oxygen ( 1 O 2 ) generation for PDT; 2) effectively inhibiting fluorescence via strong intramolecular charge transfer (ICT) to maximize the conversion of photo energy to heat for PTT or ISC process for PDT. An acceptor-donor-acceptor (A-D-A) structured small molecule (CPDT) is designed and synthesized. The biocompatible nanoparticles, FA-CNPs, prepared by encapsulating CPDT directly with a folate functionalized amphipathic copolymer, present strong NIR absorption, robust photostability, cancer cell targeting, high photothermal conversion efficiency as well as efficient 1 O 2 generation under single 808 nm laser irradiation. Furthermore, synergistic PDT and PTT effects of FA-CNPs in vivo are demonstrated by significant inhibition of tumor growth. The proposed strategy may provide a new approach to reasonably design and develop safe and efficient photosensitizers for dual phototherapy against cancer.

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Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Cited by 178 publications

References 66 publications

Kinetics of oxygen adsorption on ZnS nanoparticles synthesized by precipitation process

Kinetics of oxygen adsorption on ZnS nanoparticles synthesized by precipitation process

Biomimetic Apatite-Based Functional Nanoparticles as Promising Newcomers in Nanomedicine: Overview of 10 Years of Initiatory Research

An Acceptor–Donor–Acceptor Structured Small Molecule for Effective NIR Triggered Dual Phototherapy of Cancer

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