Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin

Dramou, Pierre; Fizir, Meriem; Taleb, Abdoh; Itatahine, Asma; Dahiru, Nasiru Sintali; Mehdi, Yamina Ait; Liu, Wei; Zhang, Jingyi; He, Hua

doi:10.1016/j.carbpol.2018.05.071

Cited by 90 publications

(49 citation statements)

References 56 publications

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“…Folic acid has a high binding affinity for the folate receptor, which is overexpressed in numerous cancers, including ovarian, endometrial, and renal carcinoma, lung, breast, and brain cancers [ 35 ]. MTX-loaded PEGylated chitosan nanoparticles had a higher cellular uptake efficiency compared to the FA-tagged group [ 36 ]. The high receptor affinity and overexpression enables folate-based nanoparticles to be highly specific, targeting tumor sites, and have great potential as a therapeutic application.…”

Section: Discussionmentioning

confidence: 99%

Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube

et al. 2020

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The surface of halloysite nanotubes (HNTs) was bifunctionalized with two ligands—folic acid and a fluorochrome. In tandem, this combination should selectively target cancer cells and provide a means for imaging the nanoparticle. Modified bi-functionalized HNTs (bi-HNTs) were then doped with the anti-cancer drug methotrexate. bi-HNTs were characterized and subjected to in vitro tests to assess cellular growth and changes in cellular behavior in three cell lines—colon cancer, osteosarcoma, and a pre-osteoblast cell line (MC3T3-E1). Cell viability, proliferation, and cell uptake efficiency were assessed. The bi-HNTs showed cytocompatibility at a wide range of concentrations. Compared with regular-sized HNTs, reduced HNTs (~6 microns) were taken up by cells in more significant amounts, but increased cytotoxicity lead to apoptosis. Multi-photon images confirmed the intracellular location of bi-HNTs, and the method of cell entry was mainly through caveolae-mediated endocytosis. The bi-HNTs showed a high drug loading efficiency with methotrexate and a prolonged period of release. Most importantly, bi-HNTs were designed as a drug carrier to target cancer cells specifically, and imaging data shows that non-cancerous cells were unaffected after exposure to MTX-doped bi-HNTs. All data provide support for our nanoparticle design as a mechanism to selectively target cancer cells and significantly reduce the side-effects caused by off-targeting of anti-cancer drugs.

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Section: Discussionmentioning

confidence: 99%

Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube

et al. 2020

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“…Similarly, chitosan oligosaccharides were assembled on Fe 3 O 4 functionalized halloysite by a simple solid-liquid interaction (COS@MHNTs) [ 96 ]. To enhance the therapeutic efficiency of the prepared nanocarrier, ligand conjugation and magnet targeting were combined.…”

Section: Supramolecular Functionalizationmentioning

confidence: 99%

“… Schematic representation of the synthesis of camptothecin CPT@FA-COS/MHNTs. Reproduced with permission from [ 96 ]. …”

Section: Figurementioning

confidence: 99%

Past, Present and Future Perspectives on Halloysite Clay Minerals

2020

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Halloysite nanotubes (HNTs), clay minerals belonging to the kaolin groups, are emerging nanomaterials which have attracted the attention of the scientific community due to their interesting features, such as low-cost, availability and biocompatibility. In addition, their large surface area and tubular structure have led to HNTs’ application in different industrial purposes. This review reports a comprehensive overview of the historical background of HNT utilization in the last 20 years. In particular it will focus on the functionalization of the surfaces, both supramolecular and covalent, following applications in several fields, including biomedicine, environmental science and catalysis.

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“…pH-responsive polymers, 22 thermosensitive polymers, 37 magnetic nanoparticles 38 ) allows tuning the release profile over a much wider range, e.g. for achieving sustained release for days 38 and sometimes weeks. 22 Alternatively, clogging of the ends of the tubes with polymers (e.g.…”

Section: Clay-based Nanomaterialsmentioning

confidence: 99%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin

Cited by 90 publications

References 56 publications

Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube

Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube

Past, Present and Future Perspectives on Halloysite Clay Minerals

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

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