Folic acid and neural tube defects

Minns, R. A.

doi:10.1038/sc.1996.79

Cited by 16 publications

(9 citation statements)

References 35 publications

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“…Em populações humanas a deficiência do ácido fólico ou vitamina B 9, na dieta das gestantes pode favorecer o surgimento deste defeito, cuja manifestação chega a ser endêmica em populações desfavorecidas (Jablonski & Chaplin 2000). O ácido fólico, um nutriente essencial, é fundamental na biossíntese dos nucleotídeos purina e pirimidina, e posteriormente na biossíntese de ADN (Barnes 1994, Minns 1996, Fleming & Copp 1998, Jablonski & Chaplin 2000. Sua ausência ou deficiência ocasionam anomalias fetais, incluindo malformação no esqueleto (Jablonski & Chaplin 2000, Moalem 2007).…”

Section: Discussionunclassified

“…O método empregado foi o estudo morfológico e/ou osteométrico dos ossos, considerando a comparação com o padrão anatômico normal das vértebras, conforme registros da literatura para a espécie (Carvalho 1963, Da Silva & Best 1994, 1996, Fettuccia & Simões-Lopes 2004. As variações e anomalias foram consideradas por comparação com humanos, e fundamentadas nas semelhanças da ontogênese dos mamíferos (Barnes 1994, Black & Scheuer 1997, Almeida 1999, Pough et al 2003, Souza et al 2006, Laeta 2007.…”

Section: Methodsunclassified

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Anomalias ósseas congênitas em Sotalia guianensis (Mammalia, Cetacea, Delphinidae) da costa centro-norte do Estado do Rio de Janeiro

2010

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Carcaças de botos-cinza Sotalia guianensis (van Bénéden, 1864) foram recuperadas entre 20 de agosto de 2001 e 13 de fevereiro de 2006, na costa centro-norte fluminense. A maior parte delas (85%) entre Barra de São João (22º35'S 41º59'W) e Quissamã (22º06'S 41º28'W). Foram estudadas as colunas vertebrais dos 20 exemplares que apresentavam mais de 60% das vértebras presentes. A coleção é formada por 75% de animais imaturos, e todos os esqueletos mostram alterações tafonômicas mínimas. Duas categorias de anomalias congênitas foram diagnosticadas, ambas relacionadas ao desenvolvimento do mesoderma paraxial. A sétima vértebra cervical (C7) foi a única afetada, as costelas cervicais e o não fechamento do arco neural atingiram 15 (75%) dos indivíduos analisados, dos quais três (15%) apresentam ambas as anomalias. Nove (45%) indivíduos apresentaram costelas cervicais uni ou bilateral, e nove (45%) indivíduos apresentaram não fechamento do arco neural; em todos os casos as vértebras contíguas eram normais. A ocorrência de anomalias nesta série do Rio de Janeiro é maior do que as referidas na literatura brasileira para outras séries de Sotalia do Amazonas, Ceará e Santa Catarina. A série de Sotalia descrita vem de uma região do litoral muito limitada e provavelmente representa uma população local. As costelas cervicais são geneticamente determinadas e podem estar concentradas por uma condição de grande proximidade biológica entre os animais; o não fechamento do arco pode ter também um componente ambiental, a ser investigado futuramente.

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Section: Discussionunclassified

Section: Methodsunclassified

Anomalias ósseas congênitas em Sotalia guianensis (Mammalia, Cetacea, Delphinidae) da costa centro-norte do Estado do Rio de Janeiro

2010

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“…51,57,58 Numerous observations support this view. For example, elevated maternal homocysteine levels have been identified in women carrying a fetus that harbors an NTD, both in serum 40 and in amnionic fluid. 57 Disordered methionine metabolism has been demonstrated in nonpregnant women who previously had given birth to a child with an NTD.…”

mentioning

confidence: 99%

“…In particular, the role of folate in methionine and homocysteine metabolism has generated considerable interest recently. 5,6,27,40,47,57,59,63,67 The metabolism of homocysteine follows one of two pathways. One involves a transsulphuration to cystathionine, catalyzed by the enzyme cystathionine synthase; cystothianine is subsequently converted to cysteine.…”

mentioning

confidence: 99%

Embryology of myelomeningocele and anencephaly

Dias

Partington

2004

FOC

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The authors review current views on of the embryogenesis of the neural tube defects (NTDs) myelomeningocele and anencephaly. In this context, the following four approaches to the study of NTDs are discussed: normal morphogenesis and timing of early human neural development from conception to the ascent of the conus medullaris; mechanical and molecular biology of neural tube closure derived from experimental and animal models; morphological and biomechanical features of the NTDs myelomeningocele and anencephaly; and the experimental evidence for the importance of both genetic and environmental influences on human NTDs. Although considerable insight into both normal neural tube closure and the factor(s) by which this process may be disrupted has been reported in recent years, the exact mechanism(s) by which human myelomeningoceles and anencephaly arise remain elusive.

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“…For example, San Martín (2014) found unfused neural arches in C. commersonii commersonii, not only in C6 and C7, but also in C3, Th1, and Th2. Both congenital anomalies are mainly related to nutritional deficiencies in the B9 vitamin complex Author copy (Minns 1996, Fleming & Copp 1998, Jablonski & Chaplin 2000, and in the case of the marine environment, these nutritional deficiencies may be related to environmental changes (Jablonski & Chaplin 2000). The observation of older individuals with congenital abnormalities suggests that this kind of anomaly does not affect the survival of individuals.…”

Section: Discussionmentioning

confidence: 99%

Pathology in skeletons of Peale’s dolphin Lagenorhynchus australis from southern South America

Martín

Macnie²,

Goodall³

et al. 2016

Dis. Aquat. Org.

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Peale's dolphin Lagenorhynchus australis is frequently seen off the coast of southern South America, where it feeds among coastal kelp beds and occasionally strands. We searched for macroscopic evidence of skeletal lesions in 78 specimens of Peale's dolphin from 2 museum collections, which contain almost all of the species' skeletons known in collections worldwide. Thirty-two specimens (41%) had some type of osteological abnormalities. In 21 cases (66%), congenital deformations were the most predominant abnormality found. Acquired lesions included (1) induced trauma: abnormal curvature (n=5 specimens) and fractures (n=2); (2) infectious diseases: spondylo-osteomyelitis (n=3); and (3) degenerative diseases: exostoses (n=8) and spondylosis deformans (n=4). It is noteworthy that all of these animals died incidentally in gillnet entanglement and were presumably healthy at the time of death. The effect that different osseous lesions may have on an animal's quality of life may depend on the area of the spine affected and the number of vertebrae involved.

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Folic acid and neural tube defects

Cited by 16 publications

References 35 publications

Anomalias ósseas congênitas em Sotalia guianensis (Mammalia, Cetacea, Delphinidae) da costa centro-norte do Estado do Rio de Janeiro

Anomalias ósseas congênitas em Sotalia guianensis (Mammalia, Cetacea, Delphinidae) da costa centro-norte do Estado do Rio de Janeiro

Embryology of myelomeningocele and anencephaly

Pathology in skeletons of Peale’s dolphin Lagenorhynchus australis from southern South America

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