Folic acid and its derivatives for targeted photodynamic therapy of cancer

Suvorov, Nikita; Mironov, A. F.; Grin, Mikhail A.

doi:10.1007/s11172-017-1973-7

Cited by 12 publications

(6 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a solution, a more selective delivery of a PS in the body is worth consideration. The tumor/normal tissue distribution of a perspective therapeutic substance can be tuned by conjugation of biologically active “warheads” (like photosensitizers) with tissue-specific moieties such as antibodies, − carbohydrates, − vitamins, − peptides, , or ligands of specific cellular receptors. − Besides, it has been shown that the conjugation of a photosensitizer with another chemotherapeutic compound might give a synergetic dual-mode action with enhanced therapeutic efficacy. , …”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy

et al. 2019

View full text Add to dashboard Cite

A new water-soluble conjugate, consisting of a chlorin-e 6 photosensitizer part, a 4-arylaminoquinazoline moiety with affinity to epidermal growth factor receptors, and a hydrophilic β-D-maltose fragment, was synthesized starting from methylpheophorbide-a in seven steps. The prepared conjugate exhibited low levels of dark cytotoxicity and pronounced photoinduced cytotoxicity at submicromolar concentrations in vitro, with an IC 50 (dark)/IC 50 (light) ratio of ∼368 and a singlet oxygen quantum yield of about 20%. In tumor-bearing Balb/c nude mice, conjugate 1 preferentially accumulates in the tumor tissue. Irradiation of the nude mice bearing A431 xenograft tumors after intravenous administration of the prepared conjugate with a relatively low light dose (50 J/cm 2 ) produced an excellent therapeutic effect with profound tumor regression and low systemic toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This specific targeting of the FePt/BP‐PEI‐FA nano‐platform was due to the binding of folic acid (FA) modified on the surface of the material to folic acid receptor (FR) expressed on the surface of cancer cells. [ 60,61 ] In recent years, various types of cell membranes including erythrocyte membranes, leukocyte membranes, and tumor cell membranes have been applied to deliver nanocarriers to promote biocompatibility and targeting. [ 62 ] Among them, the red blood cell membrane, which is rich in CD47 membrane protein as its specific marker, can disguise nanoparticles as host cells to avoid the attack of the immune system and prolong blood circulation, which is essential to increase the ability of EPR on tumor targeting.…”

Section: Surface Modification Of 2d Nanomaterialsmentioning

confidence: 99%

Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications

Kuang,

Hui,

Chen

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Cancer is one of the most serious diseases challenging human health and life span. Cancer has claimed millions of lives worldwide. Early diagnosis and effective treatment of cancer are very important for the survival of patients. In recent years, two‐dimensional (2D) nanomaterials have shown great potential in development of anticancer treatment by combining their inherent physicochemical properties after surface modification. 2D nanomaterials have attracted great interest due to their unique nanosheet structure, large surface area, and extraordinary physicochemical properties. This article reviews the advantages and application status of emerging 2D nanomaterials for targeted tumor synergistic therapy comparing with traditional therapeutic strategies. In order to investigate novel potential anticancer strategies, this paper focuses on the surface modification, cargo delivery capability and unique optical properties of emerging 2D nanomaterials. Finally, the current problems and challenges in cancer treatment are summarized and prospected.This article is protected by copyright. All rights reserved

show abstract

“…Although more frequently explored in nanocarriers for the targeted delivery of PSs, a few works have reported the synthesis of bioconjugates with improved selectivity for cancer cells [ 132 ]. Condensation of a carboxyl group with an amino group was used by Stallivieri et al [ 133 ] and Suvorov et al [ 134 ] for the conjugation of different PSs (e.g., 5,10,15,20-tetraphenylporphyrin (TPP), protoporphyrin IX (Pp IX), 5,10,15,20-tetraphenylchlorin (TPC), chlorin e 6 , pheophorbide-a and zinc(II) phthalocyanines) to FA. Although lacking studies which demonstrate enhanced internalization by cancer cells, this work can serve as guideline for the synthesis of novel FA-targeted PS conjugates.…”

Section: Ligand-targeted Photosensitizersmentioning

confidence: 99%

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

et al. 2020

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers.

show abstract

Folic acid and its derivatives for targeted photodynamic therapy of cancer

Cited by 12 publications

References 61 publications

Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy

Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy

Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

Contact Info

Product

Resources

About