Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis

Shea, Beverley; Swinden, Michael V; Ghogomu, Elizabeth Tanjong; Ortiz, Zulma; Katchamart, Wanruchada; Rader, Tamara; Bombardier, Claire; Wells, George A.; Tugwell, Peter

doi:10.3899/jrheum.130738

Cited by 159 publications

(132 citation statements)

References 23 publications

(40 reference statements)

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“…Lyc's also has anti-infl ammatory and anti-cancer properties.The studies showed that it may be effective in reducing organ toxicity such as pancreas, testis and kidney (39,(41)(42)(43). In this study, we investigated the effects of Lyc on MTX-induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

The effects of lycopene on methotrexate-induced liver injury in rats

Yucel¹,

Oğuz²,

Koçarslan³

et al. 2017

BLL

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BACKGROUND: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx) induced liver toxicity in rats. METHODS: Twenty-eight male Sprague-Dawley rats were divided into four equal groups: control, Lyc, Mtx and Mtx-L: Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for ten days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were post-treated with Lyc (10 mg/kg) for ten days after a single dose of Mtx (20 mg/kg). RESULTS: Mtx administration increased histopathological damage, TNF-α, IL-1β, TOS, TAS and OSI levels in tissues; AST, ALT levels in the blood. Sinusoidal dilatation, infl ammatory cell infi ltration and congestion were signifi cantly improved in the Mtx-L aon histopathologic examination of the rats. In Mtx-L group that were treated at the Lyc, TNF-α and IL-1β levels of liver tissue were decreased signifi cantly compared to Mtx group whereas the decrease in OSI was not signifi cant. Lyc treatment improved the AST and ALT values in Mtx-L group. But only AST improvement was signifi cant. CONCLUSIONS: The results of this study revealed that Lyc might be useful in protecting the liver from injury due to Mtx in rats by reducing the increased proinfl ammatory cytokine levels (Tab. 4, Fig. 1, Ref. 44). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

The effects of lycopene on methotrexate-induced liver injury in rats

Yucel¹,

Oğuz²,

Koçarslan³

et al. 2017

BLL

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“…Intake of 5 g rose hip powder daily is therefore not expected to negatively influence ongoing methotrexate treatment. 48 Among the RA patients, side effects were few and not confined to active treatment. The GI disturbances were reported in five patients on active treatment and in eight study participants on placebo.…”

Section: Placebo-controlled and Double-blinded Clinical Studies With mentioning

confidence: 99%

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Marstrand¹,

Campbell-Tofte²

2016

BTAT

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Rosa canina fruits (often known as rose hip) have been used in herbal remedies since ancient times. On the basis of anecdotal reports about the effects of rose hip preparations on human health and citations to the same in ancient texts, in vitro and in vivo studies have been conducted that have made it possible to learn about some active ingredients in rose hip, as well as how the component compounds might exert their effects. From such studies, it has been documented that there is a great variation in active ingredients when comparing different rose hip products. Factors which affect the quality and quantity of active ingredients in the rose hip products include the subspecies of the particular R. canina from which the fruits are harvested, the environment during plant growth, time of harvesting, and the amount of seeds and shells/husks incorporated into the preparation. Studies in animals and in humans are of great importance for determining the true bio-effects of rose hip. Such in vivo studies that have only been performed during the last 2 decades indicate that the treatment of patients with different types of joint disease with rose hip powder based on a subspecies of R. canina (Lito) containing a certain galactolipid (GOPO) can alleviate pain, improve daily activity, and even reduce the consumption of regular pain relievers. As several rose hip components have been shown to be anti-inflammatory, it is suggested that anti-inflammatory mechanisms might explain some reductions in symptoms associated with administering rose hip to arthritic conditions. Although the number of publications of randomized and placebo-controlled clinic studies with rose hip is small, the overriding evidence is that the anti-inflammatory effects from administration of rose hip preparations containing both shells and seeds are superior to preparations containing shells alone.

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“…This hyperhomocysteinemia could be explained by the administration of methotrexate and corticoid that are previously reported to generate such effect 23 . It is actually known that, homocysteine is an amino acid transformed in methionine by dependent-folate remethylation and methotrexate interferes with folate metabolism which explains the increase of homocysteine levels in methotrexate treated RA patients 24 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Rheumatoid arthritis is a chronic inflammatory disease with several triggers such as oxidative stress. The aim of this study was to assess the antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase), the total antioxidant status, lipid peroxidation (malondialdehyde) and homocysteine levels in patients with rheumatoid arthritis. The study population consists of 172 patients with rheumatoid arthritis and 147 healthy controls. The glutathione peroxidase and the glutathione reductase erythrocyte activities were determined at 340 nm. The catalase activity was measured by colorimetric assay (Góth). The superoxide dismutase activity and the total antioxidant status levels were calculated using the colorimetric method at 505 nm and 600 nm respectively. Plasma malondialdehyde was determined by the spectrofluorometric method of Yagi. Serum homocysteine was measured by fluorescence polarization immunoassay. Glutathione peroxidase, glutathione reductase and catalase activities and total antioxidant status levels were significantly lower in patients compared to controls. However, malondialdehyde and homocysteine levels in patients were significantly higher than in healthy subjects. No significant difference in superoxide dismutase activity between patients and healthy subjects was noticed. Decreased antioxidant system and increased malondialdehyde and homocysteine in Tunisian rheumatoid arthritis patients confirm the implication of the oxidative stress in rheumatoid arthritis and suggest the role of homocysteine as a pro-oxidant factor.

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Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis

Cited by 159 publications

References 23 publications

The effects of lycopene on methotrexate-induced liver injury in rats

The effects of lycopene on methotrexate-induced liver injury in rats

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

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Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis

Cited by 159 publications

References 23 publications

The effects of lycopene on methotrexate-induced liver injury in rats

The effects of lycopene on methotrexate-induced liver injury in rats

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation &ndash; part II animal and human studies

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The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies