Folic acid and creatine improve the firmness of human skin in vivo

Abstract

Employing MPLSM, dermal changes occurring in photo-aged human skin were visualized in an unprecedented manner and correlated to a loss of firmness. Treatment of aged skin with a topical formulation containing folic acid and creatine counteracted this age-dependent decline by exerting sustained effects on collagen metabolism. Our results support previous findings on the efficacy of these actives.

The effect of a vitamin A palmitate and antioxidant‐containing oil‐based moisturizer on photodamaged skin of several body sites

“…The consistency in improvements in skin condition for all body sites implies the cosmetic oil can dramatically improve the signs of photodamaged skin. Similar effects can be also observed from the emulsion‐based vehicle treatment groups for other reports, but this study compares the improvements in photodamage to a no‐treatment control group for the first time. As can be observed cumulative improvements are found with increasing treatment on all body sites.…”

“…There is increasing evidence documenting the effects of ‘antiaging’ cosmetic moisturizers on the signs of photodamaged skin. Typical agents used in these moisturizers include hydroxyacids, retinol, and its esters, salicyloylphytosphingosine, peptides, adenosine, niacinamide, creatine and folic acid, peroxisomal proliferator activated receptor agonists, hyaluronic acid fragments, and a variety of antioxidants including ascorbic acid and lipoic acid . Many of these agents have complex effects on the skin ranging from increasing dermoepidermal membrane restructuring through to inhibition of matrix metalloprotease activity and improving epidermal differentiation all of which are perturbed in photodamaged skin.…”

Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence

“…Fluorescence‐labeled primers for RT‐PCR (Applied Biosystems) were the internal control 18S ribosomal ribonucleic acid (rRNA) (Hs99999901_s1) and the target RNA collagen 1A1_(Hs00164004_m1). PCR conditions were as described earlier (6). The threshold cycle ( C t ) for collagen 1A1 gene was normalized to the internal control 18S rRNA, resulting in Δ C t ‐values (Δ C t ).…”

Design and Preparation of Single‐Chain Nanocarriers Mimicking Disordered Proteins for Combined Delivery of Dermal Bioactive Cargos

“…As a model system of dermal protective compounds, we selected folic acid (also known as folate or vitamin B 9 ), 1 . According to several in vitro and in vivo studies, dermal delivery of 1 using topical formulations offers a treatment option for photo‐aged skin . As a natural anticancer drug, we selected hinokitiol (β‐thujaplicin), 2 , as a tropolone‐related compound found in heartwood of cupressaceous plants that exhibits anticancer activity against human malignant melanoma cells as well as other cancer cell lines, including the human leukemic cell K562 and the human stomach cancer cell KATO‐III .…”