Folic acid: A positive influence on periodontal tissues during health and disease

George, JoannPauline; Lazarus, FlemingsonJ; R, Shobha

doi:10.4103/2278-344x.120582

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…Recent research has demonstrated a possible association between periodontal health and the nutritional status of individuals [92]. On the other hand, it is well known that FA deficiency is responsible for a variety of processes that have a major impact on periodontal health, causing gingival bleeding, gingival necrosis, periodontal ligament destruction, and alveolar bone loss [93,94]. The most important phenomena involved in these processes are represented by increased oxidative stress, endothelial dysfunction, genomic instability, disruption of DNA repair mechanisms, and finally cell death [94,95].…”

Section: Relationships Between Fa and Periodontal Diseasementioning

confidence: 99%

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Folic Acid and Its Role in Oral Health: A Narrative Review

et al. 2023

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Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamental powerful antioxidants with a crucial role in the genetic transcription process, are considered essential nutritional factors. Folic acid (FA), also known as folate, or Vitamin B9, plays an indispensable role in various intracellular reactions, being the main pawn, with a strong impact on medical and dental science. The aim of this paper mainly focuses on presenting the latest and most advanced aspects related to the following topics: (1) the resonance that FA, and more specifically FA deficiency, has at the level of the oral cavity; (2) the elements involved in the molecular landscape, which reflect the interaction and the possible mechanisms of action, through which FA influences oral health; and (3) the particular processes by which FA deficiency causes certain clinical conditions. Moreover, we aim to draw the attention and trigger the curiosity of health professionals on the need to know the specific host–environment interactions, particularly the linkage between individual genotype and phenotypic variability, which in the future could represent the basis of novel and effective treatment methods. From this perspective, we begin by providing an overview of the general radar echo of the human body induced by FA deficiency, before focusing on the genetic strategic substrate and biochemical processes involved in the molecular mechanisms through which FA acts at the cellular level. Finally, we reflect on the resulting conclusions: (1) the complex interrelationships between different types of cytokines (CKs) and abnormal folate metabolism are involved in the occurrence of neural tube defects (NTDs) and orofacial clefts (OFCs); (2) increased oxidative stress, endothelial dysfunction, and genomic instability, induced by folate deficiency, have a major impact on periodontal health; and (3) glutamate carboxypeptidase II, GCP2 1561C>T allelic variant, constitutes the main pawn, which specifically influences the bioavailability of natural folates and FA, as the main actors, with essential roles in oral health.

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Section: Relationships Between Fa and Periodontal Diseasementioning

confidence: 99%

“…In light of this concept, George et al and Esaki et al showed that gingival inflammatory reactions associated with relative FA deficiency respond favorably to both topical and systemic administration of folate [94,100].…”

Section: Relationships Between Fa and Periodontal Diseasementioning

confidence: 99%

Folic Acid and Its Role in Oral Health: A Narrative Review

et al. 2023

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“…deficit folne kiseline povezuje se sa teškom formom inflamacije gingive 45 . Osim toga, epitelne ćelije ne mogu efikasno da se dele bez folne kiseline 46 . Iako povezanost između folne kiseline i formiranja i razvoja parodontalnih džepova još uvek nije dovoljno jasna, prema nekim studijama upotreba folne kiseline može biti od značaja za prevenciju inflamacije gingive 47 i patoloških promena na jeziku koje su vezi sa time kao što su poremećaj govora i mastikacije 48 .…”

Section: Efekti Vitamina Folna Kiselinaunclassified

“…According to Vogel et al, folic acid deficiency is related to severe gingival inflammation 45 . Besides it, epithelial cells do not divide properly without folic acid 46 . Although the relation among folic acid, the periodontal pocket formation and development is not quite understood, according to some studies, use of folic acid could be important for the prevention of gingival inflammation 47 and pathologies related to it, like impeded speech or mastication 48 .…”

Section: Effects Of Vitamins Folic Acidmentioning

confidence: 99%

Importance of micronutrients in the oral cavity

Ranjit¹,

Takalloabdal²,

Galchenko³

2021

Acta stomatologica Naissi

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Introduction: Micronutrients play a potent role in the functioning of the different systems of the organism. It is necessary to sustain an adequate status of the micronutrients for maintaining the optimal condition of the oral cavity. The aim: Toemphasize the importance of different micronutrients for the normal functioning of the oral cavity, as well as their influence on the occurrence of various diseases of the soft and hard tissues of the oral cavity. Conclusion: Micronutrients such as vitamin C, B9 and E, calcium, zinc, copper and iron have a role in development so as anti-inflammatory and antioxidants properties Deficiency of certain micronutrients plays an important role in the development of periodontitis and caries. People with chronic inflammatory bowel disease, as well as children, pregnant and breastfeeding women, are usually deficient in these vitamins and therefore often susceptible to the development of inflammatory changes in soft tissues of oral cavity , periodontitis and caries.

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“…This will decrease local hyperplastic changes. Absence of inflammation seen in folic acid deficiency is the result of deficiency induced granulocytopenia 6. A strong interrelationship exists between sex hormones and folate coenzymes.…”

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confidence: 99%

Recurrent Idiopathic Gingival Hyperplasia

Rajkarnikar¹,

Shrestha²,

Kumar³

2019

J Nepal Soc Perio Oral Implantology

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Increase in size of the gingiva is termed as gingival enlargement. Most common type of gingival enlargement is inflammatory, which his caused due to plaque accumulation and improper oral hygiene maintenance. Orthodontic therapy can often lead to failure to improve oral hygiene. This case describes a recurrent, progressive gingival enlargement of a 19 year old female orthodontic patient in which gingivectomy was performed and repeated, which subsequently failed. Hence modified Widman’s flap was performed with medical supplements. Periodic periodontal check up is required in orthodontic cases to control the gingival inflammation. Patient compliance is also very important in such cases. There should be proper co-operation between the Orthodontist and Periodontist for successful treatment of gingival hyperplasia. Patients with such conditions should be carefully monitored and checked to avoid the recurrence and avoid further progression into chronic periodontitis.

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Folic acid: A positive influence on periodontal tissues during health and disease

Cited by 8 publications

References 3 publications

Folic Acid and Its Role in Oral Health: A Narrative Review

Folic Acid and Its Role in Oral Health: A Narrative Review

Importance of micronutrients in the oral cavity

Recurrent Idiopathic Gingival Hyperplasia

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