We define a boundary analogue of the Kang-Kashiwara-Kim-Oh generalized Schur-Weyl dualities between quantum affine algebras and Khovanov-Lauda-Rouquier (KLR) algebras. Let g be a complex simple Lie algebra and U q Lg the corresponding quantum affine algebra. We construct a functor θ F between finitedimensional modules over a quantum symmetric pair of affine type U q k ⊂ U q Lg and an orientifold KLR (oKLR) algebra arising from a framed quiver with a contravariant involution, whose nodes are indexed by finite-dimensional U q Lg-modules. With respect to the Kang-Kashiwara-Kim construction, our combinatorial model is further enriched with the poles of the trigonometric K-matrices (that is trigonometric solutions of a generalized reflection equation) intertwining the action of U q k on finite-dimensional U q Lg-modules. By construction, θ F is naturally compatible with the Kang-Kashiwara-Kim-Oh functor in that, while the latter is a functor of monoidal categories, θ F is a functor of module categories. Relying on an isomorphism à la Brundan-Kleshev-Rouquier between oKLR algebras and affine Hecke algebras of type C, we prove that θ F recovers the Schur-Weyl dualities due to Fan-Lai-Li-Luo-Wang-Watanabe in quasi-split type AIII. Finally, we construct spectral K-matrices for orientifold KLR algebras, yielding a meromorphic braiding on its category of finite-dimensional representations. We prove that, in the case of the A ∞ quiver with no fixed points and no framing, the functor θ F is exact, factors through a suitable localization, and takes values in the restricted Hernandez-Leclerc category.