Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer

Padmanabhan, Smitha; Waly, Mostafa I.; Taranikanti, Varna; Guizani, Nejib; Ali, Amanat; Rahman, Mohammad Shafiur; Al-Attabi, Zahir; Al-Malky, Raya N; Al-Maskari, Sultan; Al-Ruqaishi, Bader R.S.; Dong, Jianan; Deth, Richard C.

doi:10.1080/01635581.2018.1513047

Cited by 30 publications

(19 citation statements)

References 38 publications

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“…AOM-treated rats display oxidative stress, glutathione depletion, oxidation of proteins and oxidative damage of DNA. Folate and B12 reduced oxidative stress and the cytotoxic effects of AOM in mice [104]. Folate deficiency has been shown to have negative consequences for some immune functions.…”

Section: Folate B9mentioning

confidence: 99%

B Vitamins and Their Role in Immune Regulation and Cancer

et al. 2020

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B group vitamins represent essential micronutrients for myriad metabolic and regulatory processes required for human health, serving as cofactors used by hundreds of enzymes that carry out essential functions such as energy metabolism, DNA and protein synthesis and other critical functions. B vitamins and their corresponding vitamers are universally essential for all cellular life forms, from bacteria to humans. Humans are unable to synthesize most B vitamins and are therefore dependent on their diet for these essential micronutrients. More recently, another source of B vitamins has been identified which is derived from portions of the 1013 bacterial cells inhabiting the gastrointestinal tract. Here we review the expanding literature examining the relationship between B vitamins and the immune system and diverse cancers. Evidence of B vitamin’s role in immune cell regulation has accumulated in recent years and may help to clarify the disparate findings of numerous studies attempting to link B vitamins to cancer development. Much work remains to be carried out to fully clarify these relationships as the complexity of B vitamins’ essential functions complicates an unequivocal assessment of their beneficial or detrimental effects in inflammation and cancers.

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Section: Folate B9mentioning

confidence: 99%

B Vitamins and Their Role in Immune Regulation and Cancer

et al. 2020

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“…Some play a protective role against oxidative stress, while others inhibit cell proliferation by modifying the inflammatory process. For example, there is an association between folate deficiency and colorectal cancer, although the risk varies due to genetic interindividual variability (23).…”

Section: Introductionmentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

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“…Consistent with these findings, many reports showed evidence supporting the antioxidative effects of folic acid supplementation. In an AOM-induced colon carcinogenesis rat model, folate and vitamin B 12 supplementation alleviates AOM-stimulated GSH depletion and protein oxidation and DNA oxidative damage [32]. One report showed that a folate-deficient tumor microenvironment increased ROS and metastasis but decreased proliferation in human hepatocellular carcinoma [26].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of folic acid on colon carcinogenesis induced by azoxymethane in mice

Sohn¹,

Kim²,

Jeong³

et al. 2021

J Biomed Transl Res

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Colon cancer has been considered a leading cause of cancer-associated death. Folic acid is a vitamin necessary for cellular physiological functions and cell viability. However, the association between folic acid intake and colon cancer has been examined in several prospective cohort studies are controversial. This study investigated the effects of folate intake on colon carcinogenesis and oxidative stress in an azoxymethane (AOM)/dextran sodium sulfate (DSS) institute for cancer research (ICR) mouse model. Thirty male ICR mice (5 weeks old) were divided into the control group and the experimental group supplied 0.03% folic acid via drinking water (50 mL/week/mouse) for 6 weeks. To induce colonic pre-neoplastic lesions, the animals were subcutaneously injected three times weekly with AOM (10 mg/kg body weight), followed by 2% DSS in drinking water for a week. Folic acid supplementation significantly suppressed the total number of aberrant crypt foci and aberrant crypts. Histological image data showed that folic acid supplementation attenuated neoplastic change. In addition, we measured the thiobarbituric acid reactive substances concentration of dry feces samples to identify the effect of folic acid on reactive oxygen accumulation. The folic acid supplementation group had reduced reactive oxygen species levels in dry feces compared to the control group. In conclusion, these findings indicate that folic acid suppresses colon carcinogenesis and oxidative stress in an AOM/DSS mouse model.

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Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer

Cited by 30 publications

References 38 publications

B Vitamins and Their Role in Immune Regulation and Cancer

B Vitamins and Their Role in Immune Regulation and Cancer

Polyphenols in cancer prevention: New insights (Review)

Protective effects of folic acid on colon carcinogenesis induced by azoxymethane in mice

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