Folate, Vitamin B<sub>12</sub> and Posture

Abalan, F.; Toulet, Vèronique; Tignol, Jean-Pierre; Lacoste, G; Brument, Claire; Vuillemin, L; Ducassou, D.; Couzigou, Patrice

doi:10.1192/bjp.151.1.130a

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…CSFB12 levels were lower in AD (35.5 ± 13.7 ng/l; controls: 42.3 ± 14.4 ngll) but the difference was not statistically significant (P > 0.05; type II error?). Our results indicate poorer nutrition in patients with AD (Abalan et al, 1990). PET Centre UZiRUG, University Hospital, Gent, Belgium Our previous positron emission tomographic (PET) study showed that in demented patients with large cerebral infarcts (MID) mean regional cerebral blood flow (rCBF) and the regional metabolic oxygen consumption (rCMRO z ) were lowered to the same degree in all cerebral regions, without an increase in the regional oxygen extraction rate (rOER), compared to patients without dementia (MI).…”

Section: Mtd20mentioning

confidence: 53%

“…The degree of AD was defined as Folstein's Mini-Mental State (MMS) score of between 10 and 23 and AD was diagnosed by the criteria of the third revised Diagnostic and Statistical Manual of Mental Diseases (DSM-III-R); control subjects haad a MMS score above 23. To avoid any change in B 12 levels due to dehydration (Abalan et al•1987a), all dehydrated subjects were excluded. We also excluded all subjects obviously suffering from malnutrition or alcoholism, or taking drugs likely to interfere with B12 metabolism.…”

Section: Mtd20mentioning

confidence: 99%

“…We also excluded all subjects obviously suffering from malnutrition or alcoholism, or taking drugs likely to interfere with B12 metabolism. Changes in B 12 levels due to posture or prolonged venous occlusion were carefully avoided (Abalan et al, 1987b). The AD patients comprised five men and seven women aged (mean ± SD) 80.2 ± 5.7 years, with a MMS score of 14.8 ± 2.6; the controls comprised seven men and five women aged 78.9 ± 7.2 years, with a MMS Score of 28.3 ± 1.5.…”

Section: Mtd20mentioning

confidence: 99%

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Main Topic Dementia

1998

Euro J of Neurology

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Introduction DLB may be the second most common form of dementia. The clinical signs could overlap with Alzheimer's disease (AD). We present preliminary results in the evaluation of changes in rCBF in patients with clinical suspicion of DLB.Patients We studied seven patients (four men; aged 69.2 ± 6.3 years) with the clinical criteria of DLB as proposed by the Consortium on DLB.Imaging procedure Brain perfusion was assessed 15 min after an intravenous injection of 20 mCi (740 MBq) of 99"'Tc_ hexamethyl-propyleneamine-oxime in single-photon emission computed tomography imaging, using a standardized protocol.Analysis (I) Semiquantitative: Uptake in the brain cortex was compared with that in the cerebellar area as a reference region of interest (100%), using fixed slices in coronal and transverse OM reconstructed images. The results were expressed as a percentage of the cerebellar uptake of areas including temporal, temporal-parietal-occipital transitional cortex, occipital cortex, frontal cortex and basal ganglia in each study. (2) Qualitative: Global qualitative evaluation was reported by three nuclear medicine physicians without knowledge of the patient's suspected diagnosis, doing a blinded exploration and analysis.Results The mean findings were: (I) asymmetrical severe hypoperfusion in the temporoparietal area (five out of seven patients): (2) asymmetry in basal ganglia perfusion (three out of seven); (3) bilateral slight frontal hypoperfusion (four our of seven); and (4) unilateral hypoperfusion in the occipital cortex (one out of seven).Conclusions This short series included only patients with clinical signs suggesting DLB but no pathological confirmation, and therefore no assessment of sensitivity and/or specificity is possible. The changes in rCBF in these AD patients appeared to be predominantly unilateral, with an earlier effect on the anterior pole and occipital lobes. MT03Focal temporal lobe dysfunction In dementia of the Alzheimer's type (OAT): a eemTc-hexamethylpropyleneamlne-oxlme (HMPAO)-slngle-photon emission computed tomography (SPECT) study A peculiar pattern of cognitive impairment observed in DAT, restricted to memory and language, is termed 'focal temporal 1'OSTERABSlRAcrs A.

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Section: Mtd20mentioning

confidence: 53%

Section: Mtd20mentioning

confidence: 99%

Section: Mtd20mentioning

confidence: 99%

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Main Topic Dementia

1998

Euro J of Neurology

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“…The relatively large increase in cortisol was explained by an additional physiologic cortisol secretion induced by the changes in plasma volume, circulation, and blood pressure . Standing for 30 to 40 minutes increases vitamin B 12 and folate plasma levels by more than 10% . For proteins, these changes were demonstrated as early as 1911.…”

Section: Discussionmentioning

confidence: 99%

“…23 Standing for 30 to 40 minutes increases vitamin B 12 and folate plasma levels by more than 10%. 24 For proteins, these changes were demonstrated as early as 1911. 6 Table 2 lists some examples of changes in protein concentrations after different changes in postures.…”

Section: Changes In Plasma Concentrations After Changes In Body Positmentioning

confidence: 99%

A Change in Posture Significantly Affects Plasma Concentrations of Large Molecules Such as IgG Antibodies

Iersel¹,

Velinova²

2018

The Journal of Clinical Pharma

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In several studies with monoclonal antibodies, we observed spikes in plasma concentration profiles coinciding with a change of posture of study subjects. We hypothesized that these unexpected changes were due to fluid shifts from plasma to the interstitium. The objective of this study was to investigate size and time course of the change in total immunoglobulin G (IgG) concentration after a change in posture. Thirty-two healthy subjects were enrolled. After entry in the clinic, subjects remained upright for at least 1 hour, followed by IgG sampling. Thereafter, subjects remained supine or seated (16 subjects each) for 60 minutes while IgG was sampled frequently. The within-subject day-to-day variability of IgG measured in the same position was only 2.6%. After a change in posture from standing to supine, IgG dropped rapidly in all subjects during the first 10 minutes in the supine position (9.0% decrease) and more slowly thereafter, up to a 12.3% decrease after 60 minutes. After a change in posture from standing to sitting, the decrease in IgG was more variable and modest. After 10 minutes of sitting, IgG was 3.6% lower, and after 60 minutes IgG was 7.8% lower. Changing posture causes a bias of more than 10% in plasma concentrations of total IgG. Most of the change is reached after being 15 minutes in the same position. In clinical trials in which plasma concentrations of high-molecular drugs, highly protein-bound drugs, endogenous proteins, or blood cells are assessed, standardizing posture per time point is a useful approach for reducing variability.

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