Folate-targeted Pluronic-chitosan nanocapsules loaded with IR780 for near-infrared fluorescence imaging and photothermal-photodynamic therapy of ovarian cancer

Potara, Monica; Nagy-Simon, Timea; Focșan, Monica; Licărete, Emilia; Şoriţău, Olga; Vulpoi, Adriana; Aştilean, Simion

doi:10.1016/j.colsurfb.2021.111755

Cited by 42 publications

(17 citation statements)

References 61 publications

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“…The e cient accumulation of 3BP@PLGA-IR780 in tumor tissue is a prerequisite for the in vivo performance [58]. Fortunately, IR780 can selectively accumulate in tumor cells/tissues and emit uorescence signals [59]. FL imaging was performed using 3BP@PLGA-IR780 as a contrast agent to detect its biodistribution in vivo.…”

Section: In Vivo Distribution (Fl Imaging) Of 3bp@plga-ir780mentioning

confidence: 99%

Mitochondria-Targeted Nanoplatforms For Enhanced Photodynamic Therapy Against Hypoxia Tumor

Wen

Luo

Gao

et al. 2021

Preprint

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Background: Photodynamic therapy (PDT) is a promising therapeutic modality that can convert oxygen into cytotoxic reactive oxygen species (ROS) via photosensitizers to halt tumor growth. However, hypoxia and the unsatisfactory accumulation of photosensitizers in tumors severely diminish the therapeutic effect of PDT. In this study, a multistage nanoplatform is demonstrated to overcome these limitations by encapsulating photosensitizer IR780 and oxygen regulator 3-bromopyruvate (3BP) in poly (lactic-co-glycolic acid) (PLGA) nanocarriers.Results: The as-synthesized nanoplatforms penetrated deeply into the interior regions of tumors and preferentially remained in mitochondria due to the intrinsic characteristics of IR780. Meanwhile, 3BP could efficiently suppress oxygen consumption of tumor cells by inhibiting mitochondrial respiratory chain to further improve the generation of ROS. Furthermore, 3BP could abolish the excessive glycolytic capacity of tumor cells and lead to the collapse of ATP production, rendering tumor cells more susceptible to PDT. Successful tumor inhibition in animal models confirmed the therapeutic precision and efficiency. In addition, these nanoplatforms could act as fluorescence (FL) and photoacoustic (PA) imaging contrast agents, effectuating imaging-guided cancer treatment.Conclusions: This study provides an ideal strategy for cancer therapy by concurrent oxygen consumption reduction, oxygen-augmented PDT, energy supply reduction, mitochondria-targeted/deep-penetrated nanoplatforms and PA/FL dual-modal imaging guidance/monitoring. It is expected that such strategy will provide a promising alternative to maximize the performance of PDT in preclinical/clinical cancer treatment.

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Section: In Vivo Distribution (Fl Imaging) Of 3bp@plga-ir780mentioning

confidence: 99%

Mitochondria-Targeted Nanoplatforms For Enhanced Photodynamic Therapy Against Hypoxia Tumor

Wen

Luo

Gao

et al. 2021

Preprint

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“…According to the nanostructure, nanoparticles can be generally categorized into three types: 1) NPs with mixed hydrophilic and hydrophobic domains, 2) NPs with a core-shell structure, and 3) NPs with a double-layered capsule structure ( Figure 2 ). In this respect, natural polysaccharides such as hyaluronic acid (HA) [ 102 , 103 , 104 , 105 ], chitosan [ 102 , 106 , 107 , 108 ], chitin, heparin [ 95 , 99 , 100 ], and fucoidan [ 84 ] have been utilized as potential photosensitizer carriers due to their biocompatibility and biodegradability. In addition, not only polymers but also hydrophobic small molecule anticancer drugs (such as doxorubicin [ 96 ], docetaxel [ 97 , 107 , 109 , 110 ], paclitaxel [ 85 , 93 , 103 , 111 , 112 ], camptothecin, and quercetin [ 113 , 114 ]) can be grafted onto PS.…”

Section: Nanotechnology For Enhanced Photodynamic Therapymentioning

confidence: 99%

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Kim

Lee

2022

Biomedicines

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The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood–brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM.

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“…These observations have been ascribed by other authors to the generation of singlet oxygen and degradation of IR780 into dioxetanes and carbonyl compounds. 30,62 Please do not adjust margins…”

Section: Lcds In Photothermal Therapymentioning

confidence: 99%

“…28 In this context, heptamethyne dyes such as IR780 are interesting molecules not only for bioimaging and theranostics but as photothermal agents that yield a temperature increase and production of ROS upon illumination with near-infrared (NIR) light. 29 However, poor solubility in biological fluids, toxicity and fast clearance are major limitations 29 that have been partially overcome by encapsulating IR780 in diverse materials [30][31][32][33][34][35] or the production of CDs from IR780 and PEG by a solvothermal method. 36 In this context, we describe in this work the thermolysis of CA in DMSO to obtain CDs functionalized with acid anhydride groups which, upon reaction with alkyl amines, are transformed into CDs (LCDs) presenting features that resemble those of amphibious 17 and amphiplic 15,24,26 CDs.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic-like carbon dots as antitumoral drug vehicles and phototherapeutical agents

Ortega‐Muñoz

Vargas-Navarro

Plesselova

et al. 2021

Mater. Chem. Front.

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Folate-targeted Pluronic-chitosan nanocapsules loaded with IR780 for near-infrared fluorescence imaging and photothermal-photodynamic therapy of ovarian cancer

Cited by 42 publications

References 61 publications

Mitochondria-Targeted Nanoplatforms For Enhanced Photodynamic Therapy Against Hypoxia Tumor

Mitochondria-Targeted Nanoplatforms For Enhanced Photodynamic Therapy Against Hypoxia Tumor

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Amphiphilic-like carbon dots as antitumoral drug vehicles and phototherapeutical agents

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