Folate status, regulatory T cells and MTHFR C677T polymorphism study in allergic children

Socha-Banasiak, Anna; Kamer, Barbara; Gach, Agnieszka; Wysocka, Urszula; Jakubowski, Lucjusz; Głowacka, Ewa; Czkwianianc, Elżbieta

doi:10.1016/j.advms.2016.03.010

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…VB9 deficiency induces DNA damage in lymphocyte precursors, similarly to those observed in radiation-induced injuries [ 141 ]. In allergic children, excessive levels of VB9 are also proportional to allergic symptoms, and inversely proportionate to circulating regulatory T lymphocytes levels [ 142 ]. Folate-associated receptors are found on mature immune cells, e.g., naive T lymphocytes, and might be involved in their activation or regulation [ 143 ].…”

Section: Microbiota-derived Metabolites That Modulate Host Immunity In the Gutmentioning

confidence: 99%

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

et al. 2021

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Trillions of microorganisms, termed the “microbiota”, reside in the mammalian gastrointestinal tract, and collectively participate in regulating the host phenotype. It is now clear that the gut microbiota, metabolites, and intestinal immune function are correlated, and that alterations of the complex and dynamic host-microbiota interactions can have deep consequences for host health. However, the mechanisms by which the immune system regulates the microbiota and by which the microbiota shapes host immunity are still not fully understood. This article discusses the contribution of metabolites in the crosstalk between gut microbiota and immune cells. The identification of key metabolites having a causal effect on immune responses and of the mechanisms involved can contribute to a deeper insight into host-microorganism relationships. This will allow a better understanding of the correlation between dysbiosis, microbial-based dysmetabolism, and pathogenesis, thus creating opportunities to develop microbiota-based therapeutics to improve human health. In particular, we systematically review the role of soluble and membrane-bound microbial metabolites in modulating host immunity in the gut, and of immune cells-derived metabolites affecting the microbiota, while discussing evidence of the bidirectional impact of this crosstalk. Furthermore, we discuss the potential strategies to hear the sound of such metabolite-mediated crosstalk.

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Section: Microbiota-derived Metabolites That Modulate Host Immunity In the Gutmentioning

confidence: 99%

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

et al. 2021

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The impact of immunomodulatory factors from maternal diet during pregnancy on cow's milk allergy in offspring – A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship

Kuśmierek

Sardecka

Łoś-Rycharska

et al. 2019

Allergologia et Immunopathologia

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Association Between Folate Metabolites and the Development of Food Allergy in Children

McGowan

Hong

Selhub

et al. 2020

The Journal of Allergy and Clinical Immunology: In Practice

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Background: Studies on the association between folate/folic acid exposure and the development of allergic disease have yielded inconsistent results, which may be due, in part, to lack of data distinguishing folate from folic acid exposure.Objective: To examine the association between total folate, 5-methyltetrahydrofolate (5-MTHF), and unmetabolized folic acid (UMFA) concentrations at birth and in early childhood and the development of food sensitization (FS) and food allergy (FA).Methods: A nested case control study was performed in the Boston Birth Cohort (BBC). Total folate, 5-MTHF, and UMFA were measured at birth and in early childhood. Based on foodspecific IgE (sIgE) levels, diet, and clinical history, children were classified as FS (sIgE ≥0.35 kU/L), FA, or non-FS/FA (controls). Folate concentrations were divided into quartiles, and multiple logistic regression was used to estimate ORs and 95%CIs.Results: Of a total of 1,394 children, 507 FS and 78 FA children were identified. While mean total folate concentrations at birth were lower among those who developed FA (30.2 vs. 35.3 nmol/L; p=0.02), mean concentrations of the synthetic folic acid derivative, UMFA, were higher (1.7 vs. 1.3 nmol/L, p=0.001). Higher quartiles of UMFA at birth were associated more strongly with FA (OR 8.50;; test for trend p=0.001). Neither early childhood concentrations of 5-MTHF nor UMFA were associated with the development of FS or FA. Conclusion:Among children in the BBC, higher concentrations of UMFA at birth were associated with the development of FA, which may be due to increased exposure to synthetic folic acid in utero or underlying genetic differences in synthetic folic acid metabolism.

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Folate status, regulatory T cells and MTHFR C677T polymorphism study in allergic children

Cited by 5 publications

References 30 publications

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

The impact of immunomodulatory factors from maternal diet during pregnancy on cow's milk allergy in offspring – A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship

Association Between Folate Metabolites and the Development of Food Allergy in Children

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