Folate status of the population in the Canadian Health Measures Survey

Colapinto, Cynthia K; O’Connor, Deborah L.; Tremblay, Mark S.

doi:10.1503/cmaj.100568

Cited by 151 publications

(145 citation statements)

References 25 publications

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“…See online Supplemental Table 1 for a full list of analytes, cycle information, and analytical equipment. Collectively, 13 immunoassay biomarkers were measured: apoA1, apoB, ferritin, glycohemoglobin (Hb A 1c ), high-sensitivity C-reactive protein (hsCRP), homocysteine, insulin, parathyroid hormone (PTH), red blood cell (RBC) folate, serum folate, urine albumin, vitamin B 12 , and 25-OH vitamin D. Specific calculations and methodology were applied for RBC folate, for which concentration was calculated from the measured whole-blood folate concentration adjusted for RBC volume (hematocrit), without correction for plasma folate concentration (10 ).…”

Section: Sample Analysismentioning

confidence: 99%

Complex Reference Values for Endocrine and Special Chemistry Biomarkers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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BACKGROUND Defining laboratory biomarker reference values in a healthy population and understanding the fluctuations in biomarker concentrations throughout life and between sexes are critical to clinical interpretation of laboratory test results in different disease states. The Canadian Health Measures Survey (CHMS) has collected blood samples and health information from the Canadian household population. In collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), the data have been analyzed to determine reference value distributions and reference intervals for several endocrine and special chemistry biomarkers in pediatric, adult, and geriatric age groups. METHODS CHMS collected data and blood samples from thousands of community participants aged 3 to 79 years. We used serum samples to measure 13 immunoassay-based special chemistry and endocrine markers. We assessed reference value distributions and, after excluding outliers, calculated age- and sex-specific reference intervals, along with corresponding 90% CIs, according to CLSI C28-A3 guidelines. RESULTS We observed fluctuations in biomarker reference values across the pediatric, adult, and geriatric age range, with stratification required on the basis of age for all analytes. Additional sex partitions were required for apolipoprotein AI, homocysteine, ferritin, and high sensitivity C-reactive protein. CONCLUSIONS The unique collaboration between CALIPER and CHMS has enabled, for the first time, a detailed examination of the changes in various immunochemical markers that occur in healthy individuals of different ages. The robust age- and sex-specific reference intervals established in this study provide insight into the complex biological changes that take place throughout development and aging and will contribute to improved clinical test interpretation.

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Section: Sample Analysismentioning

confidence: 99%

Complex Reference Values for Endocrine and Special Chemistry Biomarkers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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“…Of the 6604 (88.3%) people who completed the inhome questionnaire, 5604 (84.9%) attended a mobile clinic. 17 The overall response rate was 51.7%. 17 Residents of First Nations reserves, Crown lands, certain remote regions and institutions, and full-time members of the Canadian Forces were excluded from the survey.…”

Section: Study Samplementioning

confidence: 92%

“…17 The overall response rate was 51.7%. 17 Residents of First Nations reserves, Crown lands, certain remote regions and institutions, and full-time members of the Canadian Forces were excluded from the survey. For our analysis, we excluded participants under 18 years of age (n = 1883) and pregnant women (n = 32), which left 3689 participants.…”

Section: Study Samplementioning

confidence: 92%

Prevalence estimates of chronic kidney disease in Canada: results of a nationally representative survey

Arora

Vasa²,

Brenner³

et al. 2013

CMAJ

280

223

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“…Very low prevalence rates of vitamin deficiency (Colapinto, O'Connor, & Tremblay, 2011;MacFarlane, Greene-Finestone, & Shi, 2011) and inadequate intakes (Shakur, Tarasuk, Corey, & O'Connor, 2012) are reported in the Canadian population.…”

Section: Acknowledgementsmentioning

confidence: 99%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

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Depression is associated with decreased quality of life and high mortality risk at all ages and, despite having lower prevalence in community-dwelling seniors compared to other stages of the life span or institutionalized elderly, it negatively affects seniors' health outcomes. Most evidence linking late-life depression, defined as first onset after 65 years of age, with dietary factors comes from cross-sectional studies, which cannot provide information on whether declines in diet were a consequence of depression-the reverse causality hypothesis. The Quebec Longitudinal Study on Nutrition and Aging (NuAge) provides an ideal setting to explore such a relationship among a healthy, community-dwelling elderly population. Diet is hypothesized to be a factor associated with depression. Some longitudinal evidence from studies with middle-aged adults suggests that dietary patterns such as the Mediterranean or patterns deemed "healthy" are protective against depression, while "western" and "unhealthy" patterns are risk factors for the disease. B-vitamins are important cofactors in neurotransmitter synthesis and in the enzymes of the one-carbon metabolism, which has been hypothesized to have an aetiological role in depression through its neurotoxic derivates, such as homocysteine. Nonetheless, it is still largely unknown how depression affects nutrient intake in the elderly population, raising the question of the directionality of the association. Therefore, ii the three objectives of this thesis were to explore the longitudinal associations of i) dietary patterns and macronutrient intake and of ii) B6, B12 and folate intakes with the incidence of depression in late life; and iii) to investigate whether depression significantly affects short-term nutrient intakes (reverse causality effect) in comparison to intakes among non-depressed seniors.Data for this study have been obtained from the NuAge cohort, a 4-y longitudinal study of 1,793 community-dwelling men and women aged 68 to 82 years at baseline. The main outcome is incidence of depression as defined by scores in the 30-item Geriatric Depression Scale ≥11 and or antidepressant medication use over the three years of follow-up. Participants were free of depression at the study's baseline through the exclusion of those with GDS scores ≥11 or antidepressant use at the time of the recruitment. Individuals with invalid or missing dietary information were also excluded. Dietary patterns were created through principal component analysis on amount (grams) of food items consumed in each of the 32 predefined food categories. Sex-specific tertiles of intake were created from the mean of three non-consecutive 24h-recalls. Multiple logistic regression models were adjusted for several demographic, health, and social confounders. For the study of the reverse causality hypothesis, we conducted a case-control nested within the NuAge cohort. Participants free of iii depression at baseline who developed depression at some point of follow-up were matched by age group and sex with...

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Folate status of the population in the Canadian Health Measures Survey

Cited by 151 publications

References 25 publications

Complex Reference Values for Endocrine and Special Chemistry Biomarkers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

Complex Reference Values for Endocrine and Special Chemistry Biomarkers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

Prevalence estimates of chronic kidney disease in Canada: results of a nationally representative survey

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

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