Folate status of adults living in the Canary Islands (Spain)

Henríquez, Patricia; Doreste, Jorge; Díaz-Cremades, Juan; Blanco, F. López; Álvarez-León, Eva E.; Serra-Majem, Lluís

doi:10.1024/0300-9831.74.3.187

Cited by 9 publications

(9 citation statements)

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“…Lower serum folate, erythrocyte folate and serum vitamin B12 levels in smokers, compared with those of non-smokers, may be the cause of their reduced plasma homocysteine concentration (Ganji and Kafai, 2003). Although in previous research (Henríquez et al, 2004) we found lower plasma levels of these vitamins among smokers, this was not the case with homocysteine.…”

Section: Discussioncontrasting

confidence: 49%

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

et al. 2006

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Objective: We sought to define plasma homocysteine reference values in healthy individuals in the Canary Islands and to determine its relations to folate and vitamin B12 intakes and concentrations. Design: Cross-sectional study. Setting: Population-based representative sample of 557 participants, aged 18-65 years, from the Canary Islands Nutrition Survey (ENCA). Subjects: All participants completed two 24-h dietary recalls and a general questionnaire collecting socio-demographic and health-related lifestyle information. Interventions: Plasma homocysteine and serum vitamin B12 levels were measured by immunoassay, whereas folate levels through an automated ionic capturing method. Results: Median plasma homocysteine was 11.9 mmol/l, higher in men (13.1 mmol/l) than in women (10.9 mmol/l) (Po0.001) and positively associated with age in both sexes (Po0.001). The prevalence of hyperhomocysteinaemia (X15 mmol/l), 21.4%, was also greater in men (32.2%) than in women (13.4%). There were significant negative correlations between plasma homocysteine and serum (r ¼ À0.32, Po0.001) and erythrocyte (r ¼ À0.26, Po0.001) folate, as well as serum vitamin B12 (r ¼ À0.28, Po0.001) concentrations. When divided in quartiles of vitamin intakes or concentrations, men with the lowest vitamin B12 and folate serum values had significantly higher plasma homocysteine concentrations than those in the other three quartiles. In women, hyperhomocysteinaemia was higher in the lowest quartiles of folate intake and serum and erythrocyte folate concentrations. Conclusions: These data provide further evidence that hyperhomocysteinaemia is a sensitive marker of inadequate folate and vitamin B12 status, allowing for the identification of those with greatest need for nutritional interventions.

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Section: Discussioncontrasting

confidence: 49%

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

et al. 2006

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“…[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] In addition, other factors not considered by many investigators include differences in the specific type of hormone used in the OCs, 58,59 compliance with the OC regimen, 44,58,59 and duration of OC use. 50,58 Folate status in these earlier studies was, in most cases, based solely on a comparison of serum folate concentration between groups of OC users and non-users. In addition, conclusions relative to the impact of OC use on folate status would have been strengthened if red blood cell (RBC) folate concentration would also have been measured, since this folate status indicator reflects liver folate concentration and thus body stores.…”

Section: Folatementioning

confidence: 99%

“…For example, in most studies there were no controls for dietary folate intake, vitamin supplement use, smoking, or alcohol use 39–57 . In addition, other factors not considered by many investigators include differences in the specific type of hormone used in the OCs, 58,59 compliance with the OC regimen, 44,58,59 and duration of OC use 50,58 . Folate status in these earlier studies was, in most cases, based solely on a comparison of serum folate concentration between groups of OC users and non‐users.…”

mentioning

confidence: 99%

“…In the studies from which it was concluded that OC use negatively affected folate status, none controlled for all potentially confounding variables, including differences in dietary intake and use of folic acid‐containing supplements 46,48,60,62 . Of those studies that controlled for dietary intake, with one exception, 62 no difference in RBC folate concentration between OC and non‐OC users was detected 47,50,58–61 . Similarly, in one well‐controlled study with rats, no effect of single or combined hormones was found on tissue folate concentrations 63 .…”

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confidence: 99%

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Oral contraceptive use: impact on folate, vitamin B6, and vitamin B12 status

et al. 2011

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Since many unplanned pregnancies occur while women are using oral contraceptives (OCs), it is important to understand the potential impact of these drugs on folate, vitamin B₆ , and vitamin B₁₂ status. Although a number of early studies concluded that OCs negatively impact folate status, the majority of these studies were conducted when the estrogen content of OCs was much higher. In addition, the interpretation of findings from many of these studies is problematic since no controls were included for potentially confounding factors. The presently available data do not support a conclusion that currently used OCs negatively impact folate status. In regard to vitamin B₆ , however, existing population-based data do provide evidence that current low-dose OCs may negatively impact vitamin B₆ status. The observed depression in plasma pyridoxal 5'-phosphate concentrations in OC users may reflect decreased body reserves of the vitamin, which could put women who discontinue OCs and become pregnant at risk for vitamin B₆ inadequacy during pregnancy. Functional indicators of vitamin B₁₂ status are not significantly impacted by OC use. Definitive conclusions, however, await further investigations.

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“…The specific methodology has been published elsewhere 19 . In order to assess the adherence to an MD pattern, a specific score was calculated, based on ten food items.…”

mentioning

confidence: 99%

Mediterranean diet and metabolic syndrome: a cross-sectional study in the Canary Islands

León

Henríquez²,

Serra-Majem³

2006

Public Health Nutr.

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Objective: Assessment of relation between metabolic syndrome (MS) and Mediterranean diet (MD) adherence. Design: Cross-sectional study. ATP III definition of MS was used. Adherence to MD was assessed with a Food Frequency Questionnaire. Intakes of cereal, fruit, legumes, vegetables, fish, nuts, monounsaturated to saturated ratio, alcohol from red wine, whole-fat dairy products and red meat were considered. Setting: Representative sample of population from the Canary Islands (Spain) participating in the Canarian Nutrition Survey (ENCA). Subjects: 578 adults . 18 years. Results: Of the subjects, 24.4% presented MS. Once adjusted, MD adherence was not related to MS prevalence, but subjects in the third tertile of adherence presented 70% lower prevalence of the blood pressure criteria and 2.5 times more prevalence of the glycaemia criteria with respect to the first tertile. Red meat intake was associated with higher prevalence of blood pressure criteria. Moderate alcohol intake from red wine was associated with lower prevalence of these criteria in women and lower prevalence of HDL cholesterol criteria in men. Fruit intake showed a protective effect on triglyceride criteria, whereas vegetable intake was associated with higher prevalence of this criterion. Cereals' intake showed a protective effect over insulin resistance measured by high insulinaemia level. Fruit intake showed a significative protective effect over high Homeostasis Model Assessment index. Whole-fat dairy products showed a significant protective effect on the glycaemia criteria. High monounsaturated to saturated fatty acid intake showed a protective effect on insulin resistance. Conclusions: Some components of the MD showed a protective effect on the MS and its components.

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Folate status of adults living in the Canary Islands (Spain)

Abstract: Even though nutritional folate status can be considered minimally acceptable, it may reflect the low level of fruit and vegetable consumption within the Canary Islands population.

Cited by 9 publications

References 0 publications

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

Oral contraceptive use: impact on folate, vitamin B6, and vitamin B12 status

Mediterranean diet and metabolic syndrome: a cross-sectional study in the Canary Islands

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