“…This involves nonclathrin-coated pit transport of certain ions, low-molecular-weight molecules or macromolecules from the cell surface to the cytoplasm, to internal organelles such as the ER (4), and from one plasma membrane to another plasma membrane site (e.g., apical to basolateral). Folate transport, which involves a glycerolphosphoinositol (GPI)-anchored receptor, is a well-known example of potocytosis (160,205), but Fe 2ϩ , Ca 2ϩ , alkaline phosphatase, and insulin are also transported in this manner (4,85,168). Caveolae-based endocytosis can be employed opportunistically by toxins, viruses, bacteria (227), and trypanosomes (63,232) to gain access to the cell's interior.…”