Folate receptor-targeted multimodal fluorescence mesosilica nanoparticles for imaging, delivery palladium complex and <i>in vitro</i> G-quadruplex DNA interaction

Shirani, Marziyeh Poshteh; Rezaei, Behzad; Khayamian, Taghi; Dinari, Mohammad; Karami, Kazem; Mehri-Lighvan, Zohreh; Shamili, Fazileh Hosseini; Ramazani, Mohammd; Alibolandi, Mona

doi:10.1080/07391102.2017.1411294

Cited by 16 publications

(1 citation statement)

References 42 publications

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“…The binding was studied with G-rich DNA sequences of HIV-1 promoter ( Mitrasinovic et al, 2018 ). The in vitro interaction study of folic acid conjugated meso-silica nanoparticle with G-quadruplexes has provided a new paradigm for understanding anticancer activity ( PoshtehShirani et al, 2018 ). Furthermore, another novel enantioselective approach of ligand binding with DNA G-quadruplex has taken the DNA-binding studies to an established approach ( Park et al, 2018 ).…”

Section: G-quadruplex Structuresmentioning

confidence: 99%

Non-canonical DNA structures: Diversity and disease association

2022

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A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven decades, this has been a leading light in the course of the development of modern biology and biomedical science. Apart from the predominant B-form, experimental shreds of evidence have revealed the existence of a sequence-dependent structural diversity, unusual non-canonical structures like hairpin, cruciform, Z-DNA, multistranded structures such as DNA triplex, G-quadruplex, i-motif forms, etc. The diversity in the DNA structure depends on various factors such as base sequence, ions, superhelical stress, and ligands. In response to these various factors, the polymorphism of DNA regulates various genes via different processes like replication, transcription, translation, and recombination. However, altered levels of gene expression are associated with many human genetic diseases including neurological disorders and cancer. These non-B-DNA structures are expected to play a key role in determining genetic stability, DNA damage and repair etc. The present review is a modest attempt to summarize the available literature, illustrating the occurrence of non-canonical structures at the molecular level in response to the environment and interaction with ligands and proteins. This would provide an insight to understand the biological functions of these unusual DNA structures and their recognition as potential therapeutic targets for diverse genetic diseases.

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Section: G-quadruplex Structuresmentioning

confidence: 99%

Non-canonical DNA structures: Diversity and disease association

2022

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Spectral and molecular docking studies of nucleic acids/protein binding interactions of a novel organometallic palladium (II) complex containing bioactive PTA ligands: Its synthesis, anticancer effects and encapsulation in albumin nanoparticles

Lighvan

Khonakdar

Heydari

et al. 2020

Applied Organom Chemis

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The organometallic palladium complex with nitrogen‐containing heterocycles is a potent antitumor agent. Coordination of phosphorus ligands to organometallic complexes increases their hydrophilicity, promotes ligand−DNA interactions and damage level to cancer cells, and blocks division in target cells. In this study, a phosphaadamantane palladium complex ([Pd{(C,N)‐ (C12H8NH2)} (PTA) Cl], PTA = 1,3,5‐Triaza‐7‐phosphaadamantane) (2) was synthesized via the reaction of biologically active PTA with binuclear palladacycles [Pd2{(C,N)‐(C12H8NH2)}2(μ‐Cl)2] (1). In vitro studies of the complex with DNA (calf‐thymus) explored by UV–Vis, emission titration, circular dichroism and helix melting methods showed that the complex interacts with DNA via an intercalative mechanism. Furthermore, competitive binding studies using warfarin, digoxin and ibuprofen site markers containing definite binding sites revealed the binding of the complex to site I on bovine serum albumin. The in vitro release mechanism of the palladium complex exhibited a biphasic pattern characterized by an initial burst release followed by a slower sustained release. Ultimately, in vitro evaluation of cytotoxicity and cell death showed that the complexes were able to decrease the viability of human cancer cell lines (MCF‐7 and Jurkat) in a dose‐dependent manner, but lower decreases were observed in the viability of normal fibroblast cells ASF‐4 at the dosages evaluated. Finally, the order of in vitro anticancer activities was found to be consistent with the DNA‐binding affinities.

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