Folate receptor-targeted liposomal nanocomplex for effective synergistic photothermal-chemotherapy of breast cancer in vivo

Nguyen, Van Du; Min, Hyun-Ki; Kim, Chang‐Sei; Han, Jiwon; Park, Jong-Oh; Kim, Hyungwoo

doi:10.1016/j.colsurfb.2018.10.013

Cited by 71 publications

(42 citation statements)

References 36 publications

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“…Moreover, it must be noted that no cell death was observed in cell lines treated with blank nanohybrid liposomal-metal conjugate system, thus ensuring safety of the nanohybrid liposomal-metal systems. Accordant with the in vitro observation, animal experiments revealed that synergistic application of dual therapy with the folic acid targeting liposomes could effectually inhibit the tumor growth in xenograft-bearing mice as shown in Figure 9B, indicating that this platform can provide a crucial approach to target folate receptor-overexpressing tumor cells [94].…”

Section: Combined Targeted-stimuli Responsive Systemssupporting

confidence: 68%

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Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

et al. 2021

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The epoch of nanotechnology has authorized novel investigation strategies in the area of drug delivery. Liposomes are attractive biomimetic nanocarriers characterized by their biocompatibility, high loading capacity, and their ability to reduce encapsulated drug toxicity. Nevertheless, various limitations including physical instability, lack of site specificity, and low targeting abilities have impeded the use of solo liposomes. Metal nanocarriers are emerging moieties that can enhance the therapeutic activity of many drugs with improved release and targeted potential, yet numerous barriers, such as colloidal instability, cellular toxicity, and poor cellular uptake, restrain their applicability in vivo. The empire of nanohybrid systems has shelled to overcome these curbs and to combine the criteria of liposomes and metal nanocarriers for successful theranostic delivery. Metallic moieties can be embedded or functionalized on the liposomal systems. The current review sheds light on different liposomal-metal nanohybrid systems that were designed as cellular bearers for therapeutic agents, delivering them to their targeted terminus to combat one of the most widely recognized diseases, cancer.

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Section: Combined Targeted-stimuli Responsive Systemssupporting

confidence: 68%

“…A unique nanocomplex design of gold nanorods and doxorubicin in a liposomal system conjugated with folic acid was investigated by Nguyen et al to combine photothermal-chemotherapy and target doxorubicin (Dox) to tumor cells [94]. The nanohybrid system showed a nanometric particle size of 154.32 ± 1.15 nm.…”

Section: Combined Targeted-stimuli Responsive Systemsmentioning

confidence: 99%

Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

et al. 2021

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“…Nguyen et al proposed a similar concept, but instead of the dye they used gold nanorods (entrapped inside the liposomal aqueous core alongside doxorubicin) that have high absorbance of NIR light, which allowed for liposomes to be easily heated up, releasing the encapsulated doxorubicin. These liposomes also took advantage of both passive and active targeting, as they had folate grafted to their surface via PEG chains and their particle size was smaller than 150 nm [ 97 ] (see the next section). Yet another way of facilitating drug release from thermosensitive liposomes is with the use of radiofrequency ablation (RFA).…”

Section: Drug Loading and Releasementioning

confidence: 99%

Building Blocks to Design Liposomal Delivery Systems

Juszkiewicz

Sikorski

Czogalla

2020

IJMS

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The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formulation and can be easily replaced whenever a different therapeutic effect is desired. It is tempting to describe this by an analogy to Lego blocks, since a whole set of structures, differing in their features, can be designed using a certain pool of blocks. In this review, we focus on different design strategies, where a broad variety of liposomal components facilitates the attainment of straightforward control over targeting and drug release, which leads to the design of the most promising systems for drug delivery. The key aspects of this block-based architecture became evident after its implementation in our recent works on liposomal carriers of antisense oligonucleotides and statins, which are described in the last chapter of this review.

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“…For example, surgery can be major trauma to the human body, but result in postoperative complications, while the radiotherapy and chemotherapy may destroy the human immune system and induce serious side effects [4][5][6][7]. Development of low-toxic and non-invasive cancer therapies have received increasing interests in recent years [8][9][10][11][12]. Photodynamic therapy (PDT) is a clinically used non-invasive technique for superficial skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

Zhao

Lin

et al. 2020

Nano Res.

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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Folate receptor-targeted liposomal nanocomplex for effective synergistic photothermal-chemotherapy of breast cancer in vivo

Cited by 71 publications

References 36 publications

Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

Building Blocks to Design Liposomal Delivery Systems

Recent advances in nanomaterials for sonodynamic therapy

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