Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/β-catenin signaling pathway

Le, Tuong Thi; Kim, Dong Jin

doi:10.1016/j.msec.2019.03.100

Cited by 35 publications

(7 citation statements)

References 30 publications

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“…Another strategy for preparing pH-responsive polymers is to introduce pH-cleavable linkages, which mainly include hydrazone [60][61][62], imine [63], acetal, orthoester and 2,3dialkylmaleamidic amide linkages. Hydrazone linkage [64] plays an important role in the preparation of pH-responsive polymers.…”

Section: Ph-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

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Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.

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Section: Ph-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

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“…Biopolymers, such as micelles, have long been investigated to transport various drugs for site-specific drug therapy in an effort to improve drug targeting and efficacy, as well as minimize any side effects [ 84 , 85 ]. In a previous study, two kinds of polymeric micelles, which included folate-polyethylene glycol (PEG)/hydrazone (Hyd) CUR/hydrophobic octadecylamine (C 18 )- g -polysuccinimide (PSI; FA-Cur) and PEG/Hyd-CUR/C 18 - g -PSI (NFA-Cur), were synthesized to improve the antitumor efficacy of CUR via Wnt β -catenin signaling-mediated cytoplasmic expression levels of β -catenin [ 86 ]. The findings demonstrated that both micelle forms could potentially suppress cell proliferation of SW480 CRC cell lines in a dose-dependent manner, although FA-Cur micelle treatment decreased the expression levels of β -catenin more effectively than NFA-Cur.…”

Section: Wnt β -Catenin Signaling Pathwaymentioning

confidence: 99%

“…Accordingly, these authors proposed that the mechanism responsible for the suppression of cell proliferation by both micellar formulations of CUR was due to a reduction in the expression of β -catenin in the cell cytoplasm and nucleus. They concluded that the anticancer effects of FA-Cur micelles were a promising candidate for colon cancer via the inhibition of the Wnt β -catenin signaling pathway [ 86 ].…”

Section: Wnt β -Catenin Signaling Pathwaymentioning

confidence: 99%

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Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt β-Catenin Signaling Pathway

Pashirzad

Johnston

Sahebkar

2021

Journal of Oncology

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Colorectal cancer (CRC) is the third most common cause of cancer-related death worldwide in terms of both its rates of incidence and mortality. Due to serious side effects associated with conventional chemotherapeutic treatments, many natural products with fewer adverse side effects have been considered as potential treatment options. In fact, many natural products have widely been used in various phases of clinical trials for CRC, as well as in in vitro and in vivo preclinical studies. Curcumin (CUR) and resveratrol (RES) are classified as natural polyphenolic compounds that have been demonstrated to have anticancer activity against CRC and are associated with minimal side effects. By regulating select target genes involved in several key signaling pathways in CRC, in particular, the Wnt β-catenin signaling cascade, the course of CRC may be positively altered. In the current review, we focused on the therapeutic effects of CUR and RES in CRC as they pertain to modulation of the Wnt β-catenin signaling pathway.

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“…Moreover in this area Le and Kim in their work they enhanced polymeric micellar formation; by grafting a hydrophobic and hydrophilic part to polysuccinamide backbone. C18 fatty amine (Octadecylamine) used as a hydrophobic part in that grafted polysuccinamide polymer (Le and Kim, 2019).…”

Section: Micellesmentioning

confidence: 99%

Applications of primary alkylamines in nanoparticles formation and stabilization

Enas¹

2020

ijrps

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Fatty amines or primary alkyl-amines like hexylamine, Octylamine, Decylamine, Dodecylamine, Tetradecylamine, Hexadecylamine, and Octadecylamine have been used widely in nanoparticles formation, preparation and for stabilization issue; due to their low toxicity and easily utility. The most common use of fatty amines in many research work that has been reviewed is as capping and stabilizing agent for the nanoparticles, and that is related to their abilities to stabilize nanoparticles and reduce Ostwald ripening after nanoparticles formation. Moreover, Fatty amines surfactants have been reported in many research works to assist the formation of monodisperse size because they can be adsorbed on the surface of nanoparticles which limit variability in nanoparticles size and also they can form a coat around nanoparticles that prevent agglomeration or aggregation of nanoparticles. Also, other uses that have been addressed for fatty amines as they served as hydrophobic part due to hydrocarbon chain tail. These tails for fatty amines especially those with long hydrocarbon chain more than 12 carbons like; Dodecylamine C12, tetradecylamine C14, hexadecylamine C16 and octadecylamine C18 can be fabricated and conjugated with other molecules or polymers for many nanoparticles synthesis which can help in the self-assembly of nanoparticles. Moreover, due to their high boiling point; they used as solvents and reaction catalyst facilitate the formation of nanoparticles. Finally, fatty amines surfactant used as the ligating compound also assist the formation of nanoparticles.

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Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/β-catenin signaling pathway

Cited by 35 publications

References 30 publications

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt β-Catenin Signaling Pathway

Applications of primary alkylamines in nanoparticles formation and stabilization

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