Folate Metabolism and Human Reproduction

Thaler, Christian J.

doi:10.1055/s-0034-1383058

Cited by 35 publications

(29 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Corticosteroids, halogens, isoniazid, lithium, vitamin B12, immunosuppressants and certain anticancer agents and radiotherapy have been reported causing acneiform eruptions. [59][60][61][62][63][64][65][66][67][68][69][70] We consider these dermatoses as a differential diagnosis of acne.…”

Section: Acne Exposome Factorsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

119

110

View full text Add to dashboard Cite

Background Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.ResultsAcne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.ConclusionExposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

show abstract

Section: Acne Exposome Factorsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

119

110

View full text Add to dashboard Cite

show abstract

“…Specifically, the genes methylenetetrahydrofolate reductase (MTHFR), anti-Müllerian hormone type II receptor (AMHR2), luteinizing hormone/choriogonadotropin receptor (LHCGR), progesterone receptor (PGR), and endothelial plasminogen activator inhibitor (SERPINE1) are known to potentially impact ovarian stimulation process or to be involved in OHSS (Altmäe et al, 2011;Rizk, 2009). Variations (rs1801131 and rs1801133) in the MTHFR a key regulatory enzyme in the synthesis of methionine contribute to the higher risks of pregnancy complications, diminished ovarian response to stimulation, as well as failing cycles of IVF (Azem et al, 2004;Thaler, 2014;Thaler, Budiman, Ruebsamen, Nagel, & Lohse, 2006). An association has been reported between the enhanced risk of developing polycystic ovary syndrome and the SNP rs2293275 in LHCGR gene in women (Thathapudi, Kodati, Erukkambattu, Addepally, & Qurratulain, 2015).…”

Section: Introductionmentioning

confidence: 99%

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

View full text Add to dashboard Cite

Ovarian hyperstimulation syndrome (OHSS) is an undesirable complication in the course of ovarian stimulation. This kind of stimulation is aimed at acquiring a sufficient number of high‐quality oocytes in in vitro fertilization (IVF). Whereas the predisposition to OHSS could be impacted by genetic polymorphisms in susceptible genes, the present study has been jointly conducted with an Iranian cohort to scrutinize its relevant implication. Genomic DNA was extracted from blood samples of patients with a normal ovarian response (NOR) or with OHSS. Samples were analyzed to detect polymorphisms MTHFR rs1801131, MTHFR rs1801133, AMHR2 rs2002555, LHCGR rs2293275, PGR rs10895068, and SERPINE1 rs1799889. Variations of MTHFR, AMHR2, LHCGR, and PGR genes were significantly associated with the developing OHSS. After correction for multiple analysis, this difference was not evident for PGR genotypes. The polymorphic alleles of MTHFR (rs1801131 C‐allele and rs1801133 T‐allele), AMHR2 (rs2002555 G‐allele), and LHCGR (rs2293275 G‐allele) were significantly more prevalent among patients with OHSS compared to those in the NOR group. In contrast, the minor allele of PGR single‐nucleotide polymorphism (SNP) (rs10895068, A‐allele) was more prominent among patients with a NOR than those with OHSS. No significant difference was observed in genotypes or alleles of SERPINE1 rs1799889. The observations indicated that the minor alleles of MTHFR, AMHR2, and LHCGR genes could be considered an independent risk factor in susceptibility to OHSS. Nevertheless, polymorphic allele in the PGR rs10895068 SNP contributes to preventing OHSS occurrence. Therefore, it can be argued that these genes have a significant impact on OHSS.

show abstract

“…1 Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Even if for many years nutrition was believed to cause or worsen acne, it has become a dermatological doctrine over the last decades that there is no direct association between diet and acne. [19][20][21][22][23][24] Cordain et al 25 were the first to question this belief, by studying acne-free populations having no hyperglycaemic carbohydrate and no dairy product intake.…”

Section: Introductionmentioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

Acne is an inflammatory and multifactorial skin disease. Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. Moreover, for many years nutrition was believed to cause or worsen acne. Over the last decades, however, it has become a dermatological doctrine that there is no direct association between diet and acne. Even if recent research has allowed to identify certain nutritional elements and behaviour that may impact on acne, including the excessive intake of dairy products and hyperglycaemic food, modern lifestyle nutrition, obesity and eating disorders, knowledge about the role of nutrition in the physiopathology of acne still remains sparse and hypotheses and myths continue to dominate the debate. Thus, further clinical and translational research is necessary to investigate and confirm the association between nutrition and acne.

show abstract

Folate Metabolism and Human Reproduction

Cited by 35 publications

References 36 publications

The influence of exposome on acne

The influence of exposome on acne

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Acne and nutrition: hypotheses, myths and facts

Contact Info

Product

Resources

About