Folate Intake, Serum Homocysteine and Methylenetetrahydrofolate Reductase (MTHFR) C677T Genotype Are Not Associated with Oral Cancer Risk in Puerto Rico

Weinstein, Stephanie J.; Gridley, Gloria; Harty, Lea C.; Diehl, Scott R.; Brown, Linda Morris; Winn, Deborah M.; Bravo-Otero, Eleuterio; Hayes, Richard B.

doi:10.1093/jn/132.4.762

Cited by 52 publications

(52 citation statements)

References 35 publications

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“…A population-based study of 148 oral cancer cases and 149 healthy controls conducted in Puerto Rico only investigated the role of the MTHFR C677T polymorphism and found that individuals with the TT genotype appeared to have a nonsignificantly lower risk of developing oral cancer. 45 Consistent with this finding, our data also suggest that the TT genotype was associated with a nonsignificantly lower risk of developing SCCHN. However, we found a slightly increased risk associated with the CT genotype.…”

Section: Table V -Stratification Analysis Of Variants In Mthfr Haplotsupporting

confidence: 88%

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case‐control analysis

Neumann

Lyons

Shen

et al. 2005

Intl Journal of Cancer

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Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in MTHFR are associated with risk of squamous cell carcinoma of the head and neck (SCCHN). We genotyped 3 MTHFR polymorphisms (C677T, A1298C and G1793A) and estimated their haplotypes in a hospital-based case-control study of 537 SCCHN cases and 545 cancer-free controls. The controls were frequency-matched to the cases by age (6 5 years), sex, ethnicity and smoking status. We found that the MTHFR 1298AC/ CC genotypes were associated with an approximately 35% reduction in risk of SCCHN (adjusted odds ratio = 0.65; 95% CI = 0.51-0.82) compared to the AA genotype. The MTHFR 677CT and 1793GA/AA genotypes were associated with nonsignificant increased risk of SCCHN compared to the 677CC and 1793GG genotypes, respectively. We estimated that there were 8 haplotypes and 16 haplotype genotypes based on these 3 variants. When we used the haplotypes and assumed that the 677T, 1298A and 1793A alleles were risk alleles, the adjusted odds ratios increased as the number of risk alleles increased: 1.00 for 0-1 variant, 1.85 (1.3-2.5) for any 2 risk alleles and 1.93 (1.4-2.7) for any 3 risk alleles. These results suggest that all 3 MTHFR polymorphisms may play a role in the susceptibility to SCCHN among non-Hispanic whites. Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements. ' 2005 Wiley-Liss, Inc.

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Section: Table V -Stratification Analysis Of Variants In Mthfr Haplotsupporting

confidence: 88%

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case‐control analysis

Neumann

Lyons

Shen

et al. 2005

Intl Journal of Cancer

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“…Previous studies such as Almadori et al(2001) suggest that alterations in serum homocysteine levels may increase the risk of malignancy, but in the present study, hyperhomocysteinemia (Hcy >15 μmol/L) was highly elevated in cases compared with controls but statistically insignificant. Our study was supported by Weinstein et al(2002).…”

Section: Correlation Between Serum Total Homocysteine Levels and C677supporting

confidence: 54%

“…A similar case of a minor increase in the risk of oral cancer was found among C677T genotypes (Vairaktaris et al, 2006). In Puerto Rican populations, oral cancer showed no association with MTHFR C677T polymorphism (Weinstein et al, 2002). The conflicting results regarding the associations between MTHFR C677T polymorphisms and risks for OSCC may be due to different ethnicities, different subtypes, and differences in regional dietary and local carcinogen exposures.…”

Section: Correlation Between Serum Total Homocysteine Levels and C677mentioning

confidence: 76%

“…There have been mixed reports in the literature regarding the association of MTHFR T677T polymorphism with OSCC. Weinstein et al(2002) found that in Puerto Rico, individuals with the TT genotype appeared to have a nonsignificantly lower risk of developing oral cancer. Solomon et al(2008) suggests MTHFR 677TT genotype combination implies a maximum risk for OSCC in South Indian populations.…”

Section: Correlation Between Serum Total Homocysteine Levels and C677mentioning

confidence: 95%

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Association of the C677T Polymorphism in the MTHFR Gene with Risk of Oral Squamous Cell Carcinoma in South Indian Population

Addala¹,

Kumar.CH²,

N³

et al. 2013

AJCROC

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Background: The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with reduced enzyme activity, and a significant increase in serum homocysteine (Hcy) concentration. MTHFR C677T polymorphism was likely to play an important role in the susceptibility to OSCC. Methods:In this case-control study, we genotyped 150 OSCC patients and 150 controls, using a PCR-RFLP method. The serum total homocysteine levels were quantitatively detected using commercial enzyme immunoassay (EIA) kits from Axis-Shied Diagnostics Ltd, UK.Results: In the present study heterozygous CT genotype was found statistically significantly more prevalent in patients than in controls [OR 3.38,.004], whereas TT genotype was not statistically significant [OR 2.01,. CC genotype may be protective for OSCC [OR 0.30, 95%CI 0.13-0.67, P-value 0.003]. The mean serum tHcy levels (mmol/L) <15.0 were slightly higher in CT genotype patients (11.51±1.37) than controls (10.6±2.07), whereas the mean serum tHcy levels (Mmol/L) >15.0 were higher in cases in all three CC (26.81±7.51), CT (29.26±7.67) and TT (48.85±28.07) genotypes when compared to CC (17.85±2.18), CT (17±1.0) and TT (0) with controls. However, significant variation of homocysteine levels was not observed between the genotypes of OSCC patients and controls. Conclusion:The results of the present study indicate that the frequency of MTHFR 677 'T' allele is rare and CT genotype may be associated with OSCC risk. However, the polymorphisms in the MTHFR gene (677C/T) that are reported to modulate homocysteine levels were not associated with OSCC.

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“…121 Associations with folic acid intake are less consistent. 114,120,122,123 The effect of diet on oral cancer risk may be modified by other risk factors. The benefits of a diet high in fruits and vegetables was independent of primary site of the tumor, age (stratified at 60 years), and sex.…”

Section: Diet and Body Mass Indexmentioning

confidence: 99%

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

2007

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Oral cancer incidence rates rose dramatically during the twentieth century in the United States and Europe, especially among individuals under the age of 60 years. Although influenced by age, sex, and country of origin, incidence trends were most strongly affected by elevated risk among individuals born after approximately 1915. This cohort effect was indicative of strong behavioral influences on oral cancer risk. In this article, associations between oral cancer risk and established behavioral risk factors including alcohol and tobacco use are reviewed. Additionally, possible associations between oral cancer risk and oral hygiene, diet, nutritional status, and sexual behavior as well as the influence of genetic factors on oral cancer risk are considered. Special emphasis is placed on evaluating possible risk differences in individuals above and below the age of 45 and in users and nonusers of alcohol and tobacco. Oral squamous cell carcinomas arise from several anatomic sites within the oral cavity and oropharynx, but most commonly from the oral, mobile tongue.1 In the 1980s, 2 cancer centers in the United States (U.S.) reported an increase in the proportion of incident oral tongue cancers diagnosed in men younger 40 years.2,3 Although absolute numbers had increased, these reports provided no real evidence of rising incidence. Shortly thereafter, however, a significant 2-fold increase in oral tongue cancer mortality rates between 1950 and 1982 was reported in the U.S. for men younger than 30 years. 4 This finding was corroborated by a study in Scotland. 5 Further analysis of the Scottish data revealed that the increase in incidence was not restricted to those younger than 40 but extended to all age groups less than 65 years of age born after 1920-a strong ''cohort effect.'' The cohort effect was indicated by a strong effect of year of birth on oral cancer incidence rates. A flurry of research on global changes in oral cancer incidence was stimulated by these reports.

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Folate Intake, Serum Homocysteine and Methylenetetrahydrofolate Reductase (MTHFR) C677T Genotype Are Not Associated with Oral Cancer Risk in Puerto Rico

Cited by 52 publications

References 35 publications

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case‐control analysis

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case‐control analysis

Association of the C677T Polymorphism in the MTHFR Gene with Risk of Oral Squamous Cell Carcinoma in South Indian Population

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

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