Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Stolzenberg‐Solomon, Rachael Z.; Chang, Shinn‐Jen; Leitzmann, Michael F.; Johnson, Karen A.; Johnson, Christine A.; Buys, Saundra S.; Hoover, Robert N.; Ziegler, Regina G.

doi:10.1093/ajcn/83.4.895

“…18 There is also evidence to suggest that folic acid supplementation increases the risk of breast cancer in postmenopausal women. 19 Whether these are true associations or epiphenomena requires further study, but nevertheless highlights the complexity of the one-carbon folate pathway and its interaction with carcinogenesis.…”

Section: Neural Tubule Defectsmentioning

confidence: 99%

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Carr

¹

,

Whiteley

²

,

Alfirevic

³

2009

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“…6 Although a meta-analysis did not support the protective effect of folate intake on breast cancer risk, 7 a significant interaction between alcohol and folate intake has been reported for breast cancer. [8][9][10][11][12][13] Given that proliferative benign breast disease (BBD) is associated with risk of subsequent invasive breast cancer, 14,15 the associations between intakes of alcohol and folate and the risk of proliferative BBD could have implications for the prevention of breast cancer. The results of epidemiologic studies of alcohol consumption and proliferative BBD have been inconsistent or even conflicting.…”

mentioning

confidence: 99%

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

Liu

¹

,

Tamimi

²

,

Berkey

³

et al. 2012

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WHAT'S KNOWN ON THIS SUBJECT: Alcohol consumption during adolescence and early adulthood has been associated with an increased risk of biopsy-confirmed benign breast disease (BBD), an established risk factor of breast cancer. WHAT THIS STUDY ADDS:This is the first study to analyze the association between adolescent alcohol consumption and risk of biopsy-confirmed proliferative BBD by adolescent folate intake. The result provides no evidence for protective effects of adolescent folate intake on risk of alcohol-associated BBD. abstract OBJECTIVES: To examine the combined effect of alcohol and folate intake during adolescence on the risk of proliferative benign breast disease (BBD). METHODS:We used data from 29 117 women in the Nurses' Health Study II who completed both adolescent alcohol consumption questions in 1989 and an adolescent diet questionnaire in 1998. A total of 659 women with proliferative BBD diagnosed between 1991 and 2001 were confirmed by central pathology review. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CIs), adjusted for established risk factors of breast cancer.RESULTS: Adolescent alcohol consumption was dose-dependently associated with an increased risk of proliferative BBD (hazard ratio = 1.15 per 10 g/day consumption; 95% CI, 1.03-1.28). There was no significant association between adolescent folate intake and the risk of proliferative BBD. Stratified analyses showed that each 10-g/day alcohol intake during adolescence was associated with a 21% (95% CI, 1.01-1.45) increase in the risk of proliferative BBD among women with low folate intake during adolescence, which was not significantly different from the alcohol-associated risk among women with moderate and high folate intake during adolescence (P for interaction = 0.18).CONCLUSIONS: Adolescent alcohol consumption is associated with increased risk of proliferative BBD, which may not be reduced by increased folate intake during adolescence.

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“…17 In addition, 3 cohort studies reported that the risk of invasive breast cancer associated with recent alcohol consumption did not significantly vary with recent folate intake, [30][31][32] although 8 cohort studies showed stronger positive associations between recent alcohol consumption and the risk of invasive breast cancer in women who had low folate intake or circulating folate concentrations versus women with high folate intake or circulating folate concentrations. [8][9][10][11][12][13]33 Despite the critical role of folate in gene expression and DNA repair, the reported relationship between folate intake or circulating folate levels and breast cancer risk has been inconsistent. 7 Our study provides no evidence for a protective effect of folate intake during adolescence on risk of proliferative BBD.…”

Section: Discussionmentioning

confidence: 99%

“…6 Although a meta-analysis did not support the protective effect of folate intake on breast cancer risk, 7 a significant interaction between alcohol and folate intake has been reported for breast cancer. [8][9][10][11][12][13] Given that proliferative benign breast disease (BBD) is associated with risk of subsequent invasive breast cancer, 14,15 the associations between intakes of alcohol and folate and the risk of proliferative BBD could have implications for the prevention of breast cancer. The results of epidemiologic studies of alcohol consumption and proliferative BBD have been inconsistent or even conflicting.…”

mentioning

confidence: 99%

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

2012

PEDIATRICS

0

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WHAT'S KNOWN ON THIS SUBJECT: Alcohol consumption during adolescence and early adulthood has been associated with an increased risk of biopsy-confirmed benign breast disease (BBD), an established risk factor of breast cancer. WHAT THIS STUDY ADDS:This is the first study to analyze the association between adolescent alcohol consumption and risk of biopsy-confirmed proliferative BBD by adolescent folate intake. The result provides no evidence for protective effects of adolescent folate intake on risk of alcohol-associated BBD. abstract OBJECTIVES: To examine the combined effect of alcohol and folate intake during adolescence on the risk of proliferative benign breast disease (BBD). METHODS:We used data from 29 117 women in the Nurses' Health Study II who completed both adolescent alcohol consumption questions in 1989 and an adolescent diet questionnaire in 1998. A total of 659 women with proliferative BBD diagnosed between 1991 and 2001 were confirmed by central pathology review. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CIs), adjusted for established risk factors of breast cancer.RESULTS: Adolescent alcohol consumption was dose-dependently associated with an increased risk of proliferative BBD (hazard ratio = 1.15 per 10 g/day consumption; 95% CI, 1.03-1.28). There was no significant association between adolescent folate intake and the risk of proliferative BBD. Stratified analyses showed that each 10-g/day alcohol intake during adolescence was associated with a 21% (95% CI, 1.01-1.45) increase in the risk of proliferative BBD among women with low folate intake during adolescence, which was not significantly different from the alcohol-associated risk among women with moderate and high folate intake during adolescence (P for interaction = 0.18).CONCLUSIONS: Adolescent alcohol consumption is associated with increased risk of proliferative BBD, which may not be reduced by increased folate intake during adolescence.

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Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Cited by 248 publications

References 39 publications

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

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