Folate in smokers

Okumura, Kenji; Tsukamoto, Hiroaki

doi:10.1016/j.cca.2011.01.003

Cited by 41 publications

(43 citation statements)

References 83 publications

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“…In line with current literature data about healthy populations, 24,25 smoking was clearly associated with folate and vitamin B12 deficiency in our SIBDCS patient collective. This finding can be explained by the observation that smokers consume less amounts of foods that are rich in antioxidants and tend to prefer a dietary pattern that is rich in meat and alcohol.…”

Section: Discussionsupporting

confidence: 77%

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Madanchi

Fagagnini

Fournier

et al. 2018

Inflammatory Bowel Diseases

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Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC). Results: Iron deficiency anemia was detected in 19.6% of CD patients and 21.6% of UC patients. In CD patients low BMI and nonsmoker status were positively associated with anemia. In both CD and UC, malabsorption syndrome, defined as failure of the GI tract to absorb 1 or more substances from the diet, was found to be significantly associated with anemia (6.2% and 3.8%, respectively) and current steroid use (40% CD, 52.7% UC). In CD patients with ileal (31.7% vs 20%) and colonic (29.9% vs 25%) disease location folate deficiency was significantly higher than in patients with ileocolonic CD or upper GI involvement. In CD patients, vitamin B12 deficiency was associated with the onset of stenosis and intestinal surgery (42.9% vs 32.8% and 46% vs 33% for patients with versus without B12 deficiency). Conclusion: Our data indicate that due to frequent occurrence of deficiency states, regular monitoring and substitution of vitamins and iron are mandatory and may prevent long-term intestinal and extraintestinal complications in IBD patients.

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Section: Discussionsupporting

confidence: 77%

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Madanchi

Fagagnini

Fournier

et al. 2018

Inflammatory Bowel Diseases

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“…Besides, a limitation of our study is that we did not record the daily number of cigarettes smoked and the duration of smoking, which are important elements related to Hcy concentration [11]. Finally, since a relationship between folate, Hcy concentration and second-hand exposure to cigarette smoke has been reported [28], it would have been appropriate to assess exposure by means of serum cotinine.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, although smokers showed a higher average folate intake, their mean RBC folate level was lower than in nonsmokers, and, among smokers, a higher proportion had RBC folate levels below the recommended reference value. Some authors [11,28] propose a number of mechanisms that may cause this deficiency, including the interaction of some components of tobacco smoke with folic acid coenzymes, which transforms them into biologically inactive compounds that lead to decreased circulating folic acid concentrations in smokers. Besides, a limitation of our study is that we did not record the daily number of cigarettes smoked and the duration of smoking, which are important elements related to Hcy concentration [11].…”

Section: Discussionmentioning

confidence: 99%

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

et al. 2013

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Background/Aims: An important public health issue is monitoring folate inadequacy in women of childbearing potential. The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total of 204 women were enrolled in a cross-sectional study. Folate intake was assessed by a food frequency questionnaire, and RBC folate, tHcy and MTHFR C677T genotype were determined. Results: About half of the women had a decreased RBC folate level (<305 nmol/l) and all were <906 nmol/l, even though 51% of the subjects reported use of supplements. Overall 91.5% had a high Hcy concentration. Notably, younger women, and those with a low level of education, were shown to be at higher risk of inadequate RBC folate levels. Additionally, younger women were also at higher risk of carrying the TT genotype, particularly unfavorable in the setting of a low folate status. Conclusions: Our study revealed significant folate deficiency in our Mediterranean population and higher than ideal Hcy concentrations, thus emphasizing that in these groups an improvement in the folate status is needed via a food-based approach or supplement. Consequently, public health policy strategies aiming at improved supplementation are required.

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“…Alcohol consumption can reduce the level of S-adenosylmethionine (the major methyl donor) and the activity of 5-methyltetrahydrofolate-homocysteine methyltransferase (the enzyme catalyzing the remethylation of Hcy to methionine)| [31]. Habitual smoking is independently associated with hyperhomocysteinemia [32]. Several mechanisms, such as decreased dietary intake, reduced absorption, diminished hepatic uptake, increased urinary excretion as well as a possible interaction between chemical components of cigarette smoke and folate coenzymes, may explain folate deficiency in smokers [33].…”

Section: Discussionmentioning

confidence: 99%

Diet and Lifestyle Role in Homocysteine Metabolism in Turner Syndrome

et al. 2018

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Objective: Patients with Turner syndrome (TS) have an unfavorable cardiometabolic profile. Hyperhomocysteinemia is a potential cardiovascular risk factor influenced by genetic and environmental factors, therapies, unbalanced diets and other lifestyle factors. We retrospectively studied the relationship between total plasma homocysteine (Hcy), serum vitamin B₁₂ (B₁₂) and folate concentration in TS patients, taking into account the genetic profile, diet, smoking habits, hormonal therapies and dietary supplements of the subjects. Patients and Methods: We evaluated 50 TS patients (31.5 ± 12.5 years). Medication, including vitamin supplementation, was obtained. Eating habits, cigarette smoking, alcohol and coffee consumption were investigated using phone interviews. Levels of Hcy metabolism parameters were classified by using the relevant cutoff value for an adult population and compared with a reference sample drawn from the general population. Results: Inadequate Hcy and B₁₂ levels were noted, despite vitamin supplementation. Holotranscobalamin (HoloTC) was above the relevant cutoff in the population, and supplemented subjects showed mean levels lower than nonsupplemented subjects (p = 0.005). Dietary supplementation (p = 0.038), lifestyle (coffee consumption, p = 0.01) and hormonal replacement therapy (p = 0.02) are important factors for Hcy metabolism. No genetic influence on Hcy levels was noted. Multivariable regression analysis identified vitamin supplementation (p = 0.045) as the only independent predictor of increased Hcy levels. Conclusion: Cardiovascular risk in TS can be reduced using educational approaches to a healthy lifestyle with dietary guidelines. Besides this, we also recommend measuring HoloTC for the prompt detection of B₁₂ deficiency and to consider hormone replacement therapy in the biochemical assessment of homocysteine in TS.

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Folate in smokers

Cited by 41 publications

References 83 publications

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

Diet and Lifestyle Role in Homocysteine Metabolism in Turner Syndrome

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