2011
DOI: 10.1038/modpathol.2011.112
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Folate hydrolase (prostate-specific antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature

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Cited by 58 publications
(43 citation statements)
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“…PSMA is a type II transmembrane protein that is over-expressed in PCa, including androgen-independent, advanced and metastatic disease [42–46] as well as in a few subtypes of bladder carcinoma [47], schwannoma [48], and in the tumor neovasculature of many solid tumors [49–52]. PSMA is also expressed on astrocytes where it is known as glutamate carboxypeptidase II (GCPII) and cleaves N -acetylaspartylglutamate (NAAG) into N -acetylaspartate (NAA) and glutamate [53, 54].…”
Section: Psma Biologymentioning
confidence: 99%
“…PSMA is a type II transmembrane protein that is over-expressed in PCa, including androgen-independent, advanced and metastatic disease [42–46] as well as in a few subtypes of bladder carcinoma [47], schwannoma [48], and in the tumor neovasculature of many solid tumors [49–52]. PSMA is also expressed on astrocytes where it is known as glutamate carboxypeptidase II (GCPII) and cleaves N -acetylaspartylglutamate (NAAG) into N -acetylaspartate (NAA) and glutamate [53, 54].…”
Section: Psma Biologymentioning
confidence: 99%
“…Interestingly, PSMA expression in the tumor neovasculature of some solid tumors (colon, breast, kidney, and subtypes of bladder cancer) poses potential pitfalls in imaging (32,(49)(50)(51)(52)(53)(54) but also offers potential opportunities for theranostic applications in cancers other than PC.…”
Section: Psma As Target For Pc Imaging and Therapymentioning
confidence: 99%
“…[8][9][10][11][12] The functional role of endothelial PSMA is not known and, as recent studies demonstrated, endothelial PSMA expression can vary significantly within and between different tumor types. [12][13][14] Cyclooxygenase 2 (COX2) is a key enzyme in the arachidonic acid metabolism involved in the biosynthesis of prostagladins, which contribute to a pro-angiogenic microenvironment in tumors. 15 Expression of COX2 is upregulated in squamous cell carcinoma and treatment with COX2 selective inhibitors results in reduced tumor growth.…”
mentioning
confidence: 99%