Folate, homocysteine and selected vitamins and minerals status in infertile women

Vecchia, Irene La; Paffoni, Alessio; Castiglioni, Marta; Ferrari, Stefania; Bortolus, Renata; Fusarini, Chiara Ferraris; Bettinardi, Nora; Somigliana, Edgardo; Parazzini, Fabio

doi:10.1080/13625187.2016.1263292

Cited by 18 publications

(15 citation statements)

References 29 publications

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“…There was a beneficial effect of these combined antioxidants on embryo development [ 78 ], and a positive correlation between the presence of these antioxidants and increased blastocyst cells number [ 79 ]. The evidences about the efficacy of these compounds, administered alone in culture medium, in increasing the oocytes fertilization rate [ 93 , 94 ] and in improving embryo development [ 95 , 96 , 97 , 98 , 99 ] has also been highlighted in experimental studies [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.

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Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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“…36,37 In infertile women attending an IVF clinic, it has been found that both RBC folate and vitamin B 12 levels were inadequate overall. 20 However, in those who used a folic acid supplement, there was a significantly greater likelihood of achieving the threshold for folate sufficiency (RBC folate > 906 nmol/L to protect against neural tube defects) 38 ; although few women in the folic acid group were replete (<30%), the proportion was nearly negligible in women who did not use any supplement. 20 In a study analyzing the levels of trace elements in women undergoing IVF, 39 serum and follicular fluid selenium and zinc, and follicular fluid copper levels, were significantly lower in IVF patients compared with controls.…”

Section: Supplementation With Micronutrients May Improve Fertilitymentioning

confidence: 99%

“…20 However, in those who used a folic acid supplement, there was a significantly greater likelihood of achieving the threshold for folate sufficiency (RBC folate > 906 nmol/L to protect against neural tube defects) 38 ; although few women in the folic acid group were replete (<30%), the proportion was nearly negligible in women who did not use any supplement. 20 In a study analyzing the levels of trace elements in women undergoing IVF, 39 serum and follicular fluid selenium and zinc, and follicular fluid copper levels, were significantly lower in IVF patients compared with controls. However, follicular fluid levels of aluminum and iron were significantly higher in IVF patients than in controls, which may reflect increased oxidative stress (known to enhance non-heme iron absorption).…”

Section: Supplementation With Micronutrients May Improve Fertilitymentioning

confidence: 99%

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The Impact of Preconceptional Multiple-Micronutrient Supplementation on Female Fertility

Schaefer

Nock²

2019

Clin Med�Insights�Womens�Health

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In industrialized countries, fertility has declined in recent years to the lowest recorded levels. Identifying modifiable factors that influence human fertility, such as diet, is therefore of major clinical and public health relevance. Micronutrient status is a modifiable risk factor that may have an impact on female fertility, as essential vitamins and minerals have important roles in the physiological processes that are involved. Adequate levels are important for oocyte quality, maturation, fertilization, and implantation, whereas antioxidants are vital to reduce oxidative stress, a process known to impair fertility. In women who are diagnosed as infertile, lower than recommended levels of certain micronutrients have been reported. A similar scenario has been found in a proportion of women of childbearing age in general, some of whom may be struggling to conceive. Supplementation studies with multiple micronutrients are still scarce, but the literature suggests that supplementation before conception can help restore micronutrient status to recommended levels and reduce oxidative stress when antioxidants are included. Overall, supplementation has a small but beneficial effect on fertility in healthy and infertile women, including a shorter time to pregnancy and an increased chance of becoming pregnant. Nevertheless, many studies are small or observational, and adequately powered randomized controlled trials of supplementation with multiple micronutrients are necessary to confirm any definite effects on fertility. This review substantiates the potential benefits of micronutrient supplementation beyond the prevention of neural tube defects, the traditionally viewed value of prenatal vitamin use.

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“…Previous studies have shown that Hcy concentration correlates with sperm, oocyte, and embryo qualities . Among 269 infertile women at a mean age of 37 ± 4 years, there were 69% presenting adequate plasma Hcy levels, and the pregnant women complicated with preeclampsia had significantly higher serum Hcy levels than healthy pregnant women at the same gestational age ( P < .001) . In addition, Hcy is reported to be inversely associated with fertility outcome, and lower Hcy levels have been found to correlate with a better chance of clinical pregnancy and better embryo grades in assisted reproductive technology (ART) .…”

Section: Introductionmentioning

confidence: 99%

Association between serum homocysteine level and unexplained infertility in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI): A retrospective, hospital‐based, case‐control study

Liu

Zhou

Lin

et al. 2019

Clinical Laboratory Analysis

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Background: Lower serum homocysteine (Hcy) levels are found to correlate with a better chance of clinical pregnancy and better embryo grades in assisted reproductive technology (ART). However, there is little knowledge on the association between Hcy level and unexplained infertility until now. Methods:A total of 388 infertile women undergoing IVF/ICSI treatments were recruited, including 129 women with unexplained causes (case group) and 259 women with known causes (control group), and the case group was further divided into subgroups A (≤8 μmol/L), B (>8 and <15 μmol/L), and C (≥15 μmol/L) based on the serum Hcy level. The associations between serum Hcy level and IVF/ICSI pregnancy outcomes were examined in infertile women with unknown causes.Results: A significantly higher serum Hcy level was measured in the case group than in the control group (P = .008). Subgroup analysis revealed a significant difference in the total number of oocytes retrieved among subgroups A, B, and C (P = .031), and no significant difference was seen among these three groups in terms of age, BMI, E 2 level on the hCG day, number of M-II oocytes, number of fertilized oocytes, or total number of high-quality embryos (P > .05). Spearman correlation analysis revealed a negative correlation between serum Hcy level and total number of oocytes retrieved (r = −.406, P = .019). Univariate and multivariate linear regression analyses revealed that serum Hcy level had no correlations with any IVF/ICSI outcomes. Conclusion:Serum Hcy level has no associations with IVF/ICSI pregnancy outcomes. K E Y W O R D Sassociation study, homocysteine, in vitro fertilization/intracytoplasmic sperm injection, unexplained infertility

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Folate, homocysteine and selected vitamins and minerals status in infertile women

Abstract: Folate levels were largely inadequate among women attending an infertility clinic for IVF. Vitamin B levels were also found to be inadequate.

Cited by 18 publications

References 29 publications

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

The Impact of Preconceptional Multiple-Micronutrient Supplementation on Female Fertility

Association between serum homocysteine level and unexplained infertility in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI): A retrospective, hospital‐based, case‐control study

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