Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721

Cao, Yue; Wu, Chao; Liu, Ying; Hu, Lili; Shang, Wenjing; Gao, Zhanshan; Xia, Nan

doi:10.1080/10717544.2020.1718801

Cited by 28 publications

(14 citation statements)

References 42 publications

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“…Targeting tumors based on their acidic microenvironment is one therapeutic approach to improve the selectivity of cancer treatment that has been studied lately in nanomedicine, not only to design drug delivery systems but also in other therapeutic approaches such as photodynamic [ 34 ] or combination [ 35 ] therapies. These studies use different methods to increase the concentration of the therapeutic agent in the tumor site; one is targeting tumors based on the pH.…”

Section: Resultsmentioning

confidence: 99%

“…For instance, a pH (low) insertion peptide (pHLIP) bonded to the nanoparticle can be used to direct nanoparticles to tumors [34]. Other studies use the difference on the pH to increase the drug release in the tumor microenvironment where the nanocapsules are disintegrated at acidic pH [15,35,36]. We have developed a drug delivery system that facilitates its cellular uptake at acidic pH, where its surface charge becomes cationic.…”

Section: Efficacy Study In Vivomentioning

confidence: 99%

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Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug

Pérez-Hernández

Cuscó²,

Benítez-García

et al. 2021

Biomedicines

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Cancer is one of the leading causes of mortality worldwide due, in part, to limited success of some current therapeutic approaches. The clinical potential of many promising drugs is restricted by their systemic toxicity and lack of selectivity towards cancer cells, leading to insufficient drug concentration at the tumor site. To overcome these hurdles, we developed a novel drug delivery system based on polyurea/polyurethane nanocapsules (NCs) showing pH-synchronized amphoteric properties that facilitate their accumulation and selectivity into acidic tissues, such as tumor microenvironment. We have demonstrated that the anticancer drug used in this study, a hydrophobic anionophore named T21, increases its cytotoxic activity in acidic conditions when nanoencapsulated, which correlates with a more efficient cellular internalization. A biodistribution assay performed in mice has shown that the NCs are able to reach the tumor and the observed systemic toxicity of the free drug is significantly reduced in vivo when nanoencapsulated. Additionally, T21 antitumor activity is preserved, accompanied by tumor mass reduction compared to control mice. Altogether, this work shows these NCs as a potential drug delivery system able to reach the tumor microenvironment, reducing the undesired systemic toxic effects. Moreover, these nanosystems are prepared under scalable methodologies and straightforward process, and provide tumor selectivity through a smart mechanism independent of targeting ligands.

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Section: Resultsmentioning

confidence: 99%

Section: Efficacy Study In Vivomentioning

confidence: 99%

Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug

Pérez-Hernández

Cuscó²,

Benítez-García

et al. 2021

Biomedicines

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“…FA receptors are suitable for use a target for anti‐tumor drug delivery because they are often overexpressed in tumor cells, while rarely expressed in normal organs or cells . As reported previously, FA receptors are widely overexpressed in various of cancer cells, including colorectal cancer, breast cancer, liver cancer and lung cancer cells . Therefore, FA receptor was selected as a targeting molecule and FA was chose for micelle modification.…”

Section: Discussionmentioning

confidence: 80%

Enhanced Anticancer Therapeutic Delivery to Tumor Microenvironment via Simultaneous Angiogenesis and Tumor Targeting

Zhang

Wang

et al. 2020

ChemNanoMat

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Angiogenesis is an event commonly occurring during tumorigenesis and the following development and progression provide an ideal target for anticancer drug‐targeted delivery. Nanoparticles with tumor‐cell binding ability are usually used for tumor therapy and proved to be able to accumulate in tumor tissues. The nanoparticles with dual angiogenesis and tumor‐cell targeting capacity are expected to deliver therapeutics to the lesions of tumors more efficiently and should achieve a better tumor therapeutical effect. In the present study, we employed melanoma xenograft as a tumor model, with VGB peptide and FA as angiogenesis and tumor cell guiding moieties, and with micelles as a model nanoparticle to examine our hypothesis. As a result, we proved that the dual strategy enhanced the delivery of bufalin, an anticancer agent, and achieved a better therapeutical outcome for melanoma, compared to the conventional single‐targeting methods. Since angiogenesis is common in tumor development, the simultaneous targeting strategy can be flexibly adapted to a wide range of tumors.

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“…Mesoporous silica nanoparticles (MSNPs) ( Figure 2 h) stand out among all-silicon materials with excellent physical and chemical properties, which reveal the formidable advantages as new inorganic materials for biomedical applications [ 141 ]. For instance, Cao et al [ 142 ] proved that MSN is a promising photothermotherapy carrier for inhibiting the proliferation of tumors. On one side, the adjustable pore size is beneficial for increasing drug loading and controlling the rate of drug release [ 143 ].…”

Section: Protective Carriers For Sirna Deliverymentioning

confidence: 99%

Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

Gao

Kuang

et al. 2021

Molecules

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RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a target gene via cellular machinery with much higher efficiency in contrast to other antisense-based approaches which represents an emerging therapeutic strategy for combating cancer. Distinct characters of nanoparticles, such as distinctive size, are fundamental for the efficient delivery of RNAi therapeutics, allowing for higher targeting and safety. In this review, we present the mechanism of RNAi and briefly describe the hurdles and concerns of RNAi as a cancer treatment approach in systemic delivery. Furthermore, the current nanovectors for effective tumor delivery of RNAi therapeutics are classified, and the characteristics of different nanocarriers are summarized.

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Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721

Abstract: Xia (2020) Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-

Cited by 28 publications

References 42 publications

Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug

Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug

Enhanced Anticancer Therapeutic Delivery to Tumor Microenvironment via Simultaneous Angiogenesis and Tumor Targeting

Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

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