Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development

Masso-Welch, Patricia A.; Tobias, Menachem; Kumar, Shyam C. Vasantha; Bodziak, MaryLou; Mashtare, Terry; Tamburlin, Judith; Koury, Stephen T.

doi:10.1016/j.alcohol.2011.12.003

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…When pubertal mice were fed low concentrations (3.2%) of alcohol via the drinking water there was increased ductal branching in the MG [33]. Similar changes were recorded in the MG of rats fed higher concentrations of ethanol [34].…”

Section: Discussionsupporting

confidence: 63%

Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast

Schennink

Trott

Berryhill

et al. 2015

Reproductive Toxicology

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The voluntary consumption of alcohol by humans is a modifiable lifestyle factor that has been consistently linked to a woman's risk of developing breast cancer. We have used an animal model that closely recapitulates breast development in humans to study the effect of alcohol intake on breast growth and morphology. Pubertal female pigs were fed alcohol for 4-5 weeks at 19-21% of total caloric intake, which led to average blood alcohol concentrations of 115-130mg/dL. Alongside increased liver mass, alcohol intake promoted the formation of distended ductules within lobular units in association with increased epithelial proliferation. Alcohol consumption also increased phosphorylation of the transcription factor STAT5 in the mammary epithelium, but did not lead to any evidence of precocious lactogenesis. In conclusion, feeding alcohol to female pigs having a similar physiology and mammary gland morphology to humans during a reproductive state equivalent to human adolescence leads to increased mammary gland proliferation and development of atypical lobular structures. These changes may phenocopy how alcohol intake increases the risk for developing breast cancer in humans.

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Section: Discussionsupporting

confidence: 63%

Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast

Schennink

Trott

Berryhill

et al. 2015

Reproductive Toxicology

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“…Animal studies strongly support a critical role of alcohol exposure at a young age on breast cancer development. Experimental models have robustly demonstrated that dietary exposure to ethanol during puberty causes morphologic changes in mouse mammary glands, including increases in ductal branching and epithelial growth and breast density [ 40 ]. For other cancers of the digestive tract (e.g., stomach, pancreas, colon, and rectum), however, the results are controversial and remain elusive, possibly due to the differences in study design.…”

Section: Alcohol: Tumor Initiator or Promoter?mentioning

confidence: 99%

Alcohol and Cancer: Mechanisms and Therapies

2017

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Several scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated generation of reactive oxygen species, aberrant metabolism of folate and retinoids, increased estrogen, and genetic polymorphisms. Here, we summarize the impact of alcohol drinking on the risk of cancer development and potential underlying molecular mechanisms. The interactions between alcohol abuse, anti-tumor immune response, tumor growth, and metastasis are complex. However, multiple studies have linked the immunosuppressive effects of alcohol with tumor progression and metastasis. The influence of alcohol on the host immune system and the development of possible effective immunotherapy for cancer in alcoholics are also discussed here. The conclusive biological effects of alcohol on tumor progression and malignancy have not been investigated extensively using an animal model that mimics the human disease. This review provides insights into cancer pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.

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“…Animal studies have demonstrated that dietary exposure to ethanol during puberty stimulates morphologic changes in mouse mammary glands, including increases in ductal branching (targets for malignant transformation) and epithelial proliferation and density [37,38]. However, ethanol exposure of parous mice at the beginning of natural postlactational involution has no effect on mammary gland structure and did not influence the regression of the lactating mammary gland to a resting state [39].…”

Section: Epidemiologymentioning

confidence: 99%

Links between Alcohol Consumption and Breast Cancer: A Look at the Evidence

Liu

Nguyen

Colditz

2015

Womens Health (Lond Engl)

150

112

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Alcohol consumption by adult women is consistently associated with risk of breast cancer. Several questions regarding alcohol and breast cancer need to be addressed. Menarche to first pregnancy represents a window of time when breast tissue is particularly susceptible to carcinogens. Youth alcohol consumption is common in the USA, largely in the form of binge drinking and heavy drinking. Whether alcohol intake acts early in the process of breast tumorigenesis is unclear. This review aims to focus on the influences of timing and patterns of alcohol consumption and the effect of alcohol on intermediate risk markers. We also review possible mechanisms underlying the alcohol-breast cancer association.

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Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development

Cited by 7 publications

References 47 publications

Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast

Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast

Alcohol and Cancer: Mechanisms and Therapies

Links between Alcohol Consumption and Breast Cancer: A Look at the Evidence

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