Folate deficiency in women of reproductive age in nine administrative regions of Ethiopia: an emerging public health problem

Haidar, Jemal; Umeta, Melaku; Pobocik, R.S.

doi:10.1080/16070658.2010.11734327

Cited by 45 publications

(89 citation statements)

References 18 publications

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“…The 2013 Sierra Leone Micronutrient Survey reported a prevalence of folate deficiency in WRA of ∼80% at <10 nmol/L and used the same assay and cutoff as the Cambodian survey; thus, the prevalence was also likely a correct estimate of deficiency. The 2005 Ethiopian national assessment (9 of 11 regions) of folate status in WRA reported that nearly 50% of WRA had serum folate values ≤9 nmol/L . The calculated prevalence factor was 0.89, thus we concluded that Ethiopia reported the prevalence of nearly 50% serum folate deficiency which was likely a correct estimate (Table ).…”

Section: Resultsmentioning

confidence: 62%

Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues

Rogers

Cordero

Pfeiffer

et al. 2018

Annals of the New York Academy of Sciences

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Inadequate folate status in women of reproductive age (WRA) can lead to adverse health consequences of public health significance, such as megaloblastic anemia (folate deficiency) and an increased risk of neural tube defect (NTD)‐affected pregnancies (folate insufficiency). Our review aims to evaluate current data on folate status of WRA. We queried eight databases and the World Health Organization Micronutrients Database, identifying 45 relevant surveys conducted between 2000 and 2014 in 39 countries. Several types of folate assays were used in the analysis of blood folate, and many surveys used folate cutoffs not matched to the assay. To allow better comparisons across surveys, we attempted to account for these differences. The prevalence of folate deficiency was >20% in many countries with lower income economies but was typically <5% in countries with higher income economies. Only 11 surveys reported the prevalence of folate insufficiency, which was >40% in most countries. Overall, folate status data for WRA globally are limited and must be carefully interpreted due to methodological issues. Future surveys would benefit from using the microbiologic assay to assess folate status, along with assay‐matched cutoffs to improve monitoring and evaluation of folic acid interventions, thus informing global efforts to prevent NTDs.

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Section: Resultsmentioning

confidence: 62%

Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues

Rogers

Cordero

Pfeiffer

et al. 2018

Annals of the New York Academy of Sciences

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“…However, the prevalence in Jordan was estimated by Masri [14] to be 1.1/1000 among 28,301 live births,which similar to the prevalence reported by Busby et al [15] in the United Kingdom and Ireland (1–1.5/1000 in the 1990s). High prevalence of NTDs in Sudan compared to other countries attributed to that termination is not considered after antenatal diagnosis [11] and the intake of folic acid by the mothers usually starts after conception due to lack of awareness of its importance [12, 13]. The country is under developed one and lack a lot of the resources and health programs and hence there is no routine checkup for the majority of the population including pregnant women and usually people seek medical advice late.…”

Section: Discussionmentioning

confidence: 99%

“…Despite wide availability of its natural food sources (green leafy vegetables, bananas, legumes), folic acid deficiency among women of reproductive age is common worldwide [12, 13] usually as a result of low-dietary intake or cooking losses [14]. …”

Section: Introductionmentioning

confidence: 99%

Research: Prevalence of neural tube defects Khartoum, Sudan August 2014–July 2015

et al. 2016

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Background Neural tube defects (NTDs) are birth defects that results from failure of the neural tube to develop properly during early pregnancy.Methods We studied the prevalence of neural tube defects in newborns admitted to the NICU in Soba University and Omdurman Maternity hospitals, during the period 1st August 2014 to 31st July 2015. A cross-sectional hospital based study, involved all newborns with any type of neural tube defect admitted to the NICU in the study area during the study period. Data was collected using a questionnaire reviewing the medical, social history and clinical examination.ResultsOut of the 36,785 delivered newborns during the study period, the prevalence of NTDs was 2.8:1000. Females were 56 (54.4%) predominated males 47 (45.6%). History of neural tube defects was found in 11 (10.7%) of the affected newborns siblings. Sixty-eight (66%) of the studied mothers received folic acid during pregnancy with the current child, of those who received folic acid 66 (97.1%) started folic acid after conception, 36 (54.5%) in the first trimester and 39 (57.4%) had no regular intake of the folic acid. The types of NTDs include myelomeningocele 49 (47.6%), anencephaly 18 (17.5%), encephalocele 14 (13.6%), myelomeningocele and hydrocephalus 11 (10.7%) and meningocele 8 (7.8%).ConclusionThe prevalence of neural tube defects is 2.8:1000. Myelomeningocele is the commonest encountered NTD. The use of preconception folic acid needs to be advocated.

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“…One interventional study also revealed that the consumption of folic acid before conception can decrease the risk of developing anemia and peripheral neuropathy [15]. Despite wide availability of its natural food sources (green leafy vegetables, bananas, and legumes), folic acid deficiency among women of reproductive age is common worldwide, usually as a result of low dietary intake [16, 17]. …”

Section: Introductionmentioning

confidence: 99%

Women’s Awareness and Associated Factors on Preconception Folic Acid Supplementation in Adet, Northwestern Ethiopia, 2016: Implication of Reproductive Health

Goshu

Liyeh

Ayele

et al. 2018

Journal of Nutrition and Metabolism

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Introduction Preconception folic acid supplementation is the provision of folate for reproductive age group women who have a plan to be pregnant. According to different studies, in African countries, there is poor utilization of preconception folic supplementation. So this study aimed at assessing women's awareness on preconception care and its associated factors in Adet, Northwestern Ethiopia. Methods A community-based cross-sectional study was conducted from March 1 to April 1, 2016, among 422 reproductive age group women. Systematic random sampling was used to get the study unit, and the data were collected using pretested structured questionnaire via face-to-face interview. The collected data were entered, cleaned, checked using EpiData version 3.1, and finally analyzed using SPSS version 20. Descriptive summary of the data was presented in terms of percentage and frequency. Binary and multiple logistic regressions were used in order to identify predictors using odds ratio at 95% confidence interval. Result In this study, a total of 422 reproductive age group women participated with a response rate of 100%. Of a total of 422 participants, 67 (15.9%) of the women had good awareness on preconception folic acid supplementation. Women's awareness on preconception folic acid supplementation was affected by having a chronic health problem, monthly household income, educational status, and a history of family planning use. Women who were educated (AOR 4.77, CI 1.85–6.98), had a history of family planning use (AOR 3.89, CI 1.77–8.55), had a chronic health problem (AOR 3.47, CI 2.68–5.98), and had a better monthly income (AOR 2.6, CI 2.05–6.76) had good awareness than their counterparts. Conclusion and Recommendation This study concluded that women's awareness on preconception folic acid supplementation was low. This finding suggests that there is a need to give emphasis and deliver health education about preconception folic acid supplementation for women.

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Folate deficiency in women of reproductive age in nine administrative regions of Ethiopia: an emerging public health problem

Cited by 45 publications

References 18 publications

Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues

Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues

Research: Prevalence of neural tube defects Khartoum, Sudan August 2014–July 2015

Women’s Awareness and Associated Factors on Preconception Folic Acid Supplementation in Adet, Northwestern Ethiopia, 2016: Implication of Reproductive Health

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