Folate decorated polymeric micelles for targeted delivery of the kinase inhibitor dactolisib to cancer cells

Shi, Haili; Steenbergen, Mies J. van; Lou, Bo; Liu, Yanna; Hennink, Wim E.; Kok, Robbert J.

doi:10.1016/j.ijpharm.2020.119305

Cited by 22 publications

(6 citation statements)

References 73 publications

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“…Typically, ligands are conjugated to the outer ends of the hydrophilic segment to modify polymeric micelles for active targeting [ 65 ]. Targeting ligands used to create polymeric micellar systems are typically categorized as (a) small molecular weight molecules (e.g., folic acid [ 66 ], sialic acid [ 67 ], biotin [ 68 ]); (b) antibodies and their fragments [ 69 ]; (c) peptides and proteins such as trans-activator of transcription (TAT) peptide [ 70 ] and arginine–glycine–aspartic acid (RGD) peptide [ 71 ]; and (d) aptamers [ 72 ]. Due to their high binding affinity and specificity for tumor cells, antibodies and peptides are proven to be superior ligands.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

“…Thus, many drug delivery systems had been fruitfully adjusted using MMPs to increase tumor penetration and/or tumor targeting [ 139 ]. In one investigation, a PEG (M ñ 5000)-PLA block copolymer with the MMP-responsive peptide GPLGVRGDG was investigated [ 66 ]. The peptide GPLGVRGDG was sensitive to MMP2 up-regulation at the tumor location, and MMP2 specifically degraded the peptide between the amino acids G and V. As the morphology of the micelles did not change considerably, the release rate of PTX in the presence of MMP2 was not significantly different from that in the absence of MMP2 [ 140 ].…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…The developed PMs showed high loading capacity for DOX with optimum drug release of 81.4 % at pH 5 and cytotoxicity against colon cancer cell line HT29. [141] Apart from DOX delivery, functionally modified PMs have been utilized for improved delivery of Laquinimod (LAQ) in the treatment of Crohn's disease, [196] in improved oral administration of the anticancer drug Paclitaxel, [197] for sustained release of kinase inhibitor dactolisib, [198] in investigation of cellular uptake mechanisms of monocytes [196] and most extensively in cancer therapy. [12,51,193] Table 3 presents a summary of most of the nanocarriers discussed in the present review with anticancer drug delivery application.…”

Section: Formulations With Small Yet Surface-modifiable Moieties: Pol...mentioning

confidence: 99%

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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The last decade has seen a meteoric rise in studies investigating polymeric aggregates as nanocarriers. When it comes to morphology, size, functionality, and immunostability, polymeric nanocarriers (PNCs) are unparalleled. With characteristics such as large surface area to volume ratio, amphiphilic nano‐environment, non‐toxic components, chemically modifiable composition, external surface alteration potential, uniform particle size, and stimuli‐dependent self‐assembly, PNCs have emerged as strong candidates for therapeutic applications. The article reviews the latest research on different challenges and strategies for targeted drug delivery and shall serve as guide to the researchers in designing site‐specific nanocarriers for application in future. The review systematically discusses the fundamental structural variation of the nanocarriers with emphasis on the influence of chemical alterations and the resulting effects on functionality; addresses the difficulties encountered with modes of administration; target selectivity and stimulus response.

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“…Micelles are polymeric NPs formed via supramolecular self-assembly of amphiphilic block copolymers with distinct hydrophobic and hydrophilic properties. The structure of polymeric micelles is composed of a hydrophobic core and hydrophilic outer surface (shell) as illustrated in Figure 1A(iv) [38,39]. The hydrophobic core acts as a reservoir of poorly soluble anticancer drugs that protect them against the harsh biological microenvironment and rapid metabolism [40].…”

Section: Polymeric Micellesmentioning

confidence: 99%

“…Micelles have a narrow size distribution (10-100 nm) and hydrophilic outer surface compared to other drug delivery nanocarriers, which enable long-time circulation in the bloodstream. Expanding the circulation time allows sufficient accumulation of drug-loaded micelles at the targeted sites for slow-acting cancer therapy [39,41]. Wu et al [42] synthesized phenylboronic acid (PBA)-decorated methoxy polyethylene glycol-block-(poly-N-2-hydroxyethyl-aspartamide) (mPEG-b-PHEA/PBA (PPBA)) via self-assembly.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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Folate decorated polymeric micelles for targeted delivery of the kinase inhibitor dactolisib to cancer cells

Cited by 22 publications

References 73 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

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