Folate-decorated anticancer drug and magnetic nanoparticles encapsulated polymeric carrier for liver cancer therapeutics

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

“…The common US molecular probes were produced by attaching monoclonal antibodies to the MB shell surface, whereas the large protein molecules with large diameters restrict them to freely leave the vasculature and act as real cell targeting agent. In contrast, folate is a naturally occurring small molecules with high stability and non-immunogenic property, 20,21 which is more favorable than the monoclonal antibodies. Folate shows high affinity with FA receptor (FR), which is frequently overexpressed in most malignant tumors, 20,21,28 including ovarian cancer, endometrial cancer, breast cancer, colon cancer nasopharyngeal cancer, and so on.…”

“…In contrast, folate is a naturally occurring small molecules with high stability and non-immunogenic property, 20,21 which is more favorable than the monoclonal antibodies. Folate shows high affinity with FA receptor (FR), which is frequently overexpressed in most malignant tumors, 20,21,28 including ovarian cancer, endometrial cancer, breast cancer, colon cancer nasopharyngeal cancer, and so on. In this study, the folate-modified FA-NDs showed high binding affinity to SKOV3 tumor cells as shown by the targeting efficiency experiments in vitro and in vivo.…”

“…Folate, a highly stable and non-immunogenic small molecule, was conjugated to the nanodroplet surface to further increase its tumor targeting ability. 20,21 The targeting efficiency and phase-transition effect under heating or LIFU irradiation for US imaging were simultaneously investigated in vitro and in vivo. FA-ND extravasation into tumor tissue, the phase-transition process of FA-NDs after LIFU irradiation, and FA-ND microstructure are depicted in Figure 1.…”

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

“…Because of their magnetic properties, such materials may be driven to specific sites, such as a tumor, carried by the action of a magnetic field. Due to the magnetic properties, these materials may be submitted to the action of certain types/intensities of magnetic fields, causing the temperature to rise, which, in turn, has the ability to destroy cancer cells, whose susceptibility to heat is higher than that of normal cells [11][12][13] . Cancer is a multifaceted and genomically complex disease and rapidly emerging experimental evidence has started to shed light on wide ranging factors which underlie cancer development and progression.…”

“…Confluence of information suggested various nanotechnological approaches to enhance delivery of anticancer agents to the tumor site [14][15][16][17] . Still, because of the degradation ability of PLGA, these materials can be drug carriers, which will, in turn, be released in these specific locations, thus decreasing the side effects caused by medicines to normal cells [11][12][13] . However, besides knowing the properties previously mentioned, it is important to know the behavior of the material that is being processed, to avoid future problems as stability loss or degradation.…”